Parkinson’s Disease Severity at 3 Years Can Be Predicted from Non-Motor Symptoms at Baseline
ObjectiveThe aim of this study is to present a predictive model of Parkinson’s disease (PD) global severity, measured with the Clinical Impression of Severity Index for Parkinson’s Disease (CISI-PD).MethodsThis is an observational, longitudinal study with annual follow-up assessments over 3 years (f...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2017-10-01
|
Series: | Frontiers in Neurology |
Subjects: | |
Online Access: | http://journal.frontiersin.org/article/10.3389/fneur.2017.00551/full |
id |
doaj-ace0cc46cb544e7c94e9fce4034db061 |
---|---|
record_format |
Article |
spelling |
doaj-ace0cc46cb544e7c94e9fce4034db0612020-11-24T22:44:07ZengFrontiers Media S.A.Frontiers in Neurology1664-22952017-10-01810.3389/fneur.2017.00551273270Parkinson’s Disease Severity at 3 Years Can Be Predicted from Non-Motor Symptoms at BaselineAlba Ayala0José Matías Triviño-Juárez1Maria João Forjaz2Carmen Rodríguez-Blázquez3José-Manuel Rojo-Abuin4Pablo Martínez-Martín5Centre for Human and Social Sciences, Spanish Scientific Research Council (CCHS, CSIC) and Red de Investigación en Servicios de Salud en Enfermedades Crónicas (REDISSEC), Madrid, SpainWest Health District, Primary Care Center Francia, Madrid Health Service, Madrid, SpainEpidemiology and Biostatistics Department, National School of Public Health, Institute of Health Carlos III and Red de Investigación en Servicios de Salud en Enfermedades Crónicas (REDISSEC), Madrid, SpainNational Center of Epidemiology and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Institute of Health Carlos III, Madrid, SpainInstitute of Economics, Geography and Demography, Centre for Human and Social Sciences, Spanish National Research Council (CSIC), Madrid, SpainNational Center of Epidemiology and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Institute of Health Carlos III, Madrid, SpainObjectiveThe aim of this study is to present a predictive model of Parkinson’s disease (PD) global severity, measured with the Clinical Impression of Severity Index for Parkinson’s Disease (CISI-PD).MethodsThis is an observational, longitudinal study with annual follow-up assessments over 3 years (four time points). A multilevel analysis and multiple imputation techniques were performed to generate a predictive model that estimates changes in the CISI-PD at 1, 2, and 3 years.ResultsThe clinical state of patients (CISI-PD) significantly worsened in the 3-year follow-up. However, this change was of small magnitude (effect size: 0.44). The following baseline variables were significant predictors of the global severity change: baseline global severity of disease, levodopa equivalent dose, depression and anxiety symptoms, autonomic dysfunction, and cognitive state. The goodness-of-fit of the model was adequate, and the sensitive analysis showed that the data imputation method applied was suitable.ConclusionDisease progression depends more on the individual’s baseline characteristics than on the 3-year time period. Results may contribute to a better understanding of the evolution of PD including the non-motor manifestations of the disease.http://journal.frontiersin.org/article/10.3389/fneur.2017.00551/fullParkinson’s diseasedisease global severitypredictive modelmultilevel analysismultiple imputation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Alba Ayala José Matías Triviño-Juárez Maria João Forjaz Carmen Rodríguez-Blázquez José-Manuel Rojo-Abuin Pablo Martínez-Martín |
spellingShingle |
Alba Ayala José Matías Triviño-Juárez Maria João Forjaz Carmen Rodríguez-Blázquez José-Manuel Rojo-Abuin Pablo Martínez-Martín Parkinson’s Disease Severity at 3 Years Can Be Predicted from Non-Motor Symptoms at Baseline Frontiers in Neurology Parkinson’s disease disease global severity predictive model multilevel analysis multiple imputation |
author_facet |
Alba Ayala José Matías Triviño-Juárez Maria João Forjaz Carmen Rodríguez-Blázquez José-Manuel Rojo-Abuin Pablo Martínez-Martín |
author_sort |
Alba Ayala |
title |
Parkinson’s Disease Severity at 3 Years Can Be Predicted from Non-Motor Symptoms at Baseline |
title_short |
Parkinson’s Disease Severity at 3 Years Can Be Predicted from Non-Motor Symptoms at Baseline |
title_full |
Parkinson’s Disease Severity at 3 Years Can Be Predicted from Non-Motor Symptoms at Baseline |
title_fullStr |
Parkinson’s Disease Severity at 3 Years Can Be Predicted from Non-Motor Symptoms at Baseline |
title_full_unstemmed |
Parkinson’s Disease Severity at 3 Years Can Be Predicted from Non-Motor Symptoms at Baseline |
title_sort |
parkinson’s disease severity at 3 years can be predicted from non-motor symptoms at baseline |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Neurology |
issn |
1664-2295 |
publishDate |
2017-10-01 |
description |
ObjectiveThe aim of this study is to present a predictive model of Parkinson’s disease (PD) global severity, measured with the Clinical Impression of Severity Index for Parkinson’s Disease (CISI-PD).MethodsThis is an observational, longitudinal study with annual follow-up assessments over 3 years (four time points). A multilevel analysis and multiple imputation techniques were performed to generate a predictive model that estimates changes in the CISI-PD at 1, 2, and 3 years.ResultsThe clinical state of patients (CISI-PD) significantly worsened in the 3-year follow-up. However, this change was of small magnitude (effect size: 0.44). The following baseline variables were significant predictors of the global severity change: baseline global severity of disease, levodopa equivalent dose, depression and anxiety symptoms, autonomic dysfunction, and cognitive state. The goodness-of-fit of the model was adequate, and the sensitive analysis showed that the data imputation method applied was suitable.ConclusionDisease progression depends more on the individual’s baseline characteristics than on the 3-year time period. Results may contribute to a better understanding of the evolution of PD including the non-motor manifestations of the disease. |
topic |
Parkinson’s disease disease global severity predictive model multilevel analysis multiple imputation |
url |
http://journal.frontiersin.org/article/10.3389/fneur.2017.00551/full |
work_keys_str_mv |
AT albaayala parkinsonsdiseaseseverityat3yearscanbepredictedfromnonmotorsymptomsatbaseline AT josematiastrivinojuarez parkinsonsdiseaseseverityat3yearscanbepredictedfromnonmotorsymptomsatbaseline AT mariajoaoforjaz parkinsonsdiseaseseverityat3yearscanbepredictedfromnonmotorsymptomsatbaseline AT carmenrodriguezblazquez parkinsonsdiseaseseverityat3yearscanbepredictedfromnonmotorsymptomsatbaseline AT josemanuelrojoabuin parkinsonsdiseaseseverityat3yearscanbepredictedfromnonmotorsymptomsatbaseline AT pablomartinezmartin parkinsonsdiseaseseverityat3yearscanbepredictedfromnonmotorsymptomsatbaseline |
_version_ |
1725692918601089024 |