FHL3 Contributes to EMT and Chemotherapy Resistance Through Up-Regulation of Slug and Activation of TGFβ/Smad-Independent Pathways in Gastric Cancer

FHL3 Contributes to EMT and Chemotherapy Resistance Through Up-Regulation of Slug and Activation of TGFβ/Smad-Independent Pathways in Gastric Cancer

BackgroundGastric cancer presents high risk of metastasis and chemotherapy resistance. Hence, it is important to understand the mechanisms of gastric cancer distant metastasis and chemotherapeutic resistance. Our previous study has revealed Four and a Half LIM Domains 3 (FHL3) plays as a binding par...

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Bibliographic Details
Main Authors: Guodong Cao, Pengping Li, Xiaobo He, Mengyao Jin, Mengying Li, Sihan Chen, Xin Xu, Qiang Sun, Maoming Xiong, Bo Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Oncology
Subjects:
epithelial to mesenchymal transition
chemotherapy resistance
FHL3
ubiquitination
gastric cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.649029/full

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