Novel Semi-Synthetic Cu (II)–Cardamonin Complex Exerts Potent Anticancer Activity against Triple-Negative Breast and Pancreatic Cancer Cells via Inhibition of the Akt Signaling Pathway

Novel Semi-Synthetic Cu (II)–Cardamonin Complex Exerts Potent Anticancer Activity against Triple-Negative Breast and Pancreatic Cancer Cells via Inhibition of the Akt Signaling Pathway

Cardamonin is a polyphenolic natural product that has been shown to possess cytotoxic activity against a variety of cancer cell lines. We previously reported the semi-synthesis of a novel Cu (II)–cardamonin complex (<b>19</b>) that demonstrated potent antitumour activity. In this study,...

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Bibliographic Details
Main Authors: Md Shahadat Hossan, Mohammed Khaled Bin Break, Tracey D. Bradshaw, Hilary M. Collins, Christophe Wiart, Teng-Jin Khoo, Ahmed Alafnan
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Molecules
Subjects:
cardamonin
complex
cytotoxicity
Akt
Online Access:https://www.mdpi.com/1420-3049/26/8/2166

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