Targeted, Site-Specific, Delivery Vehicles of Therapeutics for COVID-19 Patients. Brief Review

Targeted, Site-Specific, Delivery Vehicles of Therapeutics for COVID-19 Patients. Brief Review

Definitive pharmacological therapies for COVID-19 have yet to be identified. Several hundred trials are ongoing globally in the hope of a solution. However, nearly all treatments rely on systemic delivery but COVID-19 damages the lungs preferentially. The use of a targeted delivery approach is revie...

Full description

Bibliographic Details
Main Authors:	Nicholas Kipshidze MD, PhD, DSc, Patrick Iversen PhD, Thomas R. Porter MD, Nodar Kipshidze MPH, Fakiha Siddiqui BDS, George Dangas MD, PhD, Jawed Fareed PhD
Format:	Article
Language:	English
Published:	SAGE Publishing 2020-09-01
Series:	Clinical and Applied Thrombosis/Hemostasis
Online Access:	https://doi.org/10.1177/1076029620954911

Similar Items

Viral Coagulopathy in Patients With COVID-19: Treatment and Care
by: Nickolas Kipshidze MD, PhD, DSc, et al.
Published: (2020-07-01)

Catheter-Based Local Delivery of Therapeutics to the Lungs for Severe or Critically Ill Patients with COVID-19
by: George Dangas, et al.
Published: (2021-02-01)

Is the Reason of Increased D-Dimer Levels in COVID-19 Because of ACE-2-Induced Apoptosis in Endothelium?
by: Nil Guler MD, et al.
Published: (2020-07-01)

Factor Xa Inhibitory Profile of Apixaban, Betrixaban, Edoxaban, and Rivaroxaban Does Not Fully Reflect Their Biologic Spectrum
by: Fakiha Siddiqui BDS, et al.
Published: (2019-05-01)

Comparative Anticoagulant and Thrombin Generation Inhibitory Profile of Heparin, Sulodexide and Its Components
by: Fakiha Siddiqui BDS, et al.
Published: (2020-10-01)

Thrombin Generation Profile in Various Lymphoma Sub-Groups and Its Augmentation by Andexanet Alfa
by: Fakiha Siddiqui BDS, et al.
Published: (2020-12-01)

Investigation of the Optimal Dose aPCC in Reversing the Effect of Factor Xa Inhibitors—An In Vitro Study
by: Nina Haagenrud Schultz MD, PhD, et al.
Published: (2021-05-01)

Assay-Based Differentiation in the Neutralization Profile of Unfractionated Heparin, Enoxaparin, and Fondaparinux by Andexanet Alfa
by: Fakiha Siddiqui BDS, et al.
Published: (2020-01-01)

Reversal of Factor Xa Inhibitors by Andexanet Alfa May Increase Thrombogenesis Compared to Pretreatment Values
by: Fakiha Siddiqui BDS, et al.
Published: (2019-07-01)

Porcine Mucosal Heparin Shortage Crisis! What Are the Options?
by: Jawed Fareed PhD, et al.
Published: (2019-09-01)

Brief Report: Heterogeneity of Acquired Resistance Mechanisms to Osimertinib and Savolitinib
by: Sun Min Lim, MD, PhD, et al.
Published: (2021-06-01)

Development of an Algorithm to Predict Mortality in Patients With Sepsis and Coagulopathy
by: Amanda Walborn PhD, et al.
Published: (2020-03-01)

Quantification of DNA Damage in Heart Tissue as a Novel Prediction Tool for Therapeutic Prognosis of Patients With Dilated Cardiomyopathy
by: Toshiyuki Ko, MD, PhD, et al.
Published: (2019-10-01)

Oncogenic Fusions May Be Frequently Present at Resistance of EGFR Tyrosine Kinase Inhibitors in Patients With NSCLC: A Brief Report
by: Diego Enrico, MD, et al.
Published: (2020-06-01)

Comparative Studies on the Anticoagulant Profile of Branded Enoxaparin and a New Biosimilar Version
by: Dalia Qneibi MD, et al.
Published: (2020-09-01)

Biomarkers of Platelet Activation and Their Prognostic Value in Patients With Sepsis-Associated Disseminated Intravascular Coagulopathy
by: Gracelene Wegrzyn MD, et al.
Published: (2021-02-01)

Endothelial Dysfunction Is Associated with Mortality and Severity of Coagulopathy in Patients with Sepsis and Disseminated Intravascular Coagulation
by: Amanda Walborn PhD, et al.
Published: (2019-05-01)

Safe Delivery of Postoperative Radiotherapy for Thymic Carcinoma Located on the Outflow Graft of a Left Ventricular Assist Device
by: Genki Edward Sato, MD, et al.
Published: (2021-01-01)

Coil embolization of renal artery aneurysms: Simultaneous delivery of three microdevices with a novel 6-Fr guiding sheath
by: Jun Otaka, MD, PhD, et al.
Published: (2021-03-01)

First-in-Human Percutaneous Circumferential Annuloplasty for Secondary Tricuspid Regurgitation
by: Vivek Y. Reddy, MD, et al.
Published: (2020-11-01)

Factors Associated With Rebound Hyperthermia After Targeted Temperature Management in Out-of-Hospital Cardiac Arrest Patients: An Explorative Substudy of the Time-Differentiated Therapeutic Hypothermia in Out-of-Hospital Cardiac Arrest Survivors Trial
by: Aki Holm, MB, et al.
Published: (2021-07-01)

Time Course of Inflammatory and Procoagulant Markers in the Early Period After Total Hip Replacement
by: Peter Poredos MD, PhD, et al.
Published: (2021-02-01)

A case of respiratory infection possibly caused by Mycobacterium triviale: Current problems on diagnostic and therapeutic strategies
by: Asako Okabayashi, MD, et al.
Published: (2017-01-01)

Testosterone Deficiency and Bone Metabolism Damage in Testicular Cancer Survivors
by: Martina Ondrusova PhD, MPH, et al.
Published: (2018-05-01)

Current overview of the genetic background of atrial fibrillation: Possible therapeutic gene targets for the treatment of atrial fibrillation
by: Tetsushi Furukawa, MD, PhD, et al.
Published: (2012-06-01)

Progress in Cellular Neurorestoratology: A Brief Introduction to the IANR Supplement Issue
by: Hongyun Huang M.D., Ph.D.
Published: (2013-01-01)

A Narrative Review of Emerging Therapeutics for COVID-19
by: Van C. Willis, PhD, et al.
Published: (2020-12-01)

The New Explorations of the Neurorestorative Process: A Brief Introduction to the IANR Special Issue
by: Huang Hongyun M.D., Ph.D.
Published: (2014-01-01)

Therapeutic response of immunoglobulin 4-related aortitis and pancreatitis demonstrated by diffusion-weighted MRI
by: Shogo Doi, et al.
Published: (2019-09-01)

Cessation Attitudes and Preferences in Head and Neck Cancer Patients and Implications for Cessation Program Design: A Brief Report
by: Chandylen L Nightingale PhD, MPH, et al.
Published: (2019-04-01)

Enhanced Drug Delivery to the Skin Using Liposomes
by: Gert Blueschke, MD, et al.
Published: (2018-07-01)

Markers of Inflammation and Infection in Sepsis and Disseminated Intravascular Coagulation
by: Priya Patel BS, et al.
Published: (2019-04-01)

Favor, Not Fear, the Clinical Advancement of Neurorestoratology: A Brief Introduction to the IANR Supplement Issue
by: Hongyun Huang M.D., Ph.D.
Published: (2012-01-01)

Therapeutic Potential of Selenium and Selenium Compounds in Cervical Cancer
by: Ewa Jablonska PhD, et al.
Published: (2021-03-01)

The Risk of Venous Thromboembolism is Not Equal for all Patients Who Undergo Total Joint Replacement
by: Alfonso Tafur MD, MS, RPVI, FSVM, et al.
Published: (2019-04-01)

Real-Time Fluorescence Imaging Using Indocyanine Green to Assess Therapeutic Effects of Near-Infrared Photoimmunotherapy in Tumor Model Mice
by: Adrian Rosenberg, et al.
Published: (2020-06-01)

Association Between Sexual Health and Delivery Mode
by: Mihyon Song, MD, et al.
Published: (2014-12-01)

Interrelationship of MMP-9, Proteoglycan-4, and Inflammation in Osteoarthritis Patients Undergoing Total Hip Arthroplasty
by: Hannah Slovacek BS, et al.
Published: (2021-03-01)

Relevance of computed tomography and magnetic resonance imaging for penile metastasis after prostatectomy: uncommon case report and brief review of the literature
by: Valeria Fiaschetti, MD, PhD, et al.
Published: (2016-09-01)

Direct Oral Anticoagulants and Cancer-Associated Thrombosis Management. Where Do We Stand in 2019?
by: Eduardo Ramacciotti MD, PhD, et al.
Published: (2019-06-01)