Secondary White Matter Injury and Therapeutic Targets After Subarachnoid Hemorrhage
Aneurysmal subarachnoid hemorrhage (SAH) is one of the special stroke subtypes with high mortality and mobility. Although the mortality of SAH has decreased by 50% over the past two decades due to advances in neurosurgery and management of neurocritical care, more than 70% of survivors suffer from v...
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doaj-ad03e86b10dc4c3890980db772172adf2021-07-15T06:38:16ZengFrontiers Media S.A.Frontiers in Neurology1664-22952021-07-011210.3389/fneur.2021.659740659740Secondary White Matter Injury and Therapeutic Targets After Subarachnoid HemorrhageXufang Ru0Xufang Ru1Ling Gao2Jiru Zhou3Qiang Li4Qiang Li5Shilun Zuo6Yujie Chen7Yujie Chen8Zhi Liu9Zhi Liu10Hua Feng11Hua Feng12State Key Laboratory of Trauma, Burn and Combined Injury, Department of Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaChongqing Key Laboratory of Precision Neuromedicine and Neuroregenaration, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaDepartment of General Practice, Audio-Visual Education Center, Third Military Medical University (Army Medical University), Chongqing, ChinaDepartment of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaState Key Laboratory of Trauma, Burn and Combined Injury, Department of Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaChongqing Key Laboratory of Precision Neuromedicine and Neuroregenaration, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaDepartment of Neurology, Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaState Key Laboratory of Trauma, Burn and Combined Injury, Department of Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaChongqing Key Laboratory of Precision Neuromedicine and Neuroregenaration, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaState Key Laboratory of Trauma, Burn and Combined Injury, Department of Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaChongqing Key Laboratory of Precision Neuromedicine and Neuroregenaration, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaState Key Laboratory of Trauma, Burn and Combined Injury, Department of Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaChongqing Key Laboratory of Precision Neuromedicine and Neuroregenaration, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaAneurysmal subarachnoid hemorrhage (SAH) is one of the special stroke subtypes with high mortality and mobility. Although the mortality of SAH has decreased by 50% over the past two decades due to advances in neurosurgery and management of neurocritical care, more than 70% of survivors suffer from varying degrees of neurological deficits and cognitive impairments, leaving a heavy burden on individuals, families, and the society. Recent studies have shown that white matter is vulnerable to SAH, and white matter injuries may be one of the causes of long-term neurological deficits caused by SAH. Attention has recently focused on the pivotal role of white matter injury in the pathophysiological processes after SAH, mainly related to mechanical damage caused by increased intracerebral pressure and the metabolic damage induced by blood degradation and hypoxia. In the present review, we sought to summarize the pathophysiology processes and mechanisms of white matter injury after SAH, with a view to providing new strategies for the prevention and treatment of long-term cognitive dysfunction after SAH.https://www.frontiersin.org/articles/10.3389/fneur.2021.659740/fullsubarachnoid hemorrhagewhite matter injuryoligodendrocytediffusion tensor imagingtherapeutic targets |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xufang Ru Xufang Ru Ling Gao Jiru Zhou Qiang Li Qiang Li Shilun Zuo Yujie Chen Yujie Chen Zhi Liu Zhi Liu Hua Feng Hua Feng |
spellingShingle |
Xufang Ru Xufang Ru Ling Gao Jiru Zhou Qiang Li Qiang Li Shilun Zuo Yujie Chen Yujie Chen Zhi Liu Zhi Liu Hua Feng Hua Feng Secondary White Matter Injury and Therapeutic Targets After Subarachnoid Hemorrhage Frontiers in Neurology subarachnoid hemorrhage white matter injury oligodendrocyte diffusion tensor imaging therapeutic targets |
author_facet |
Xufang Ru Xufang Ru Ling Gao Jiru Zhou Qiang Li Qiang Li Shilun Zuo Yujie Chen Yujie Chen Zhi Liu Zhi Liu Hua Feng Hua Feng |
author_sort |
Xufang Ru |
title |
Secondary White Matter Injury and Therapeutic Targets After Subarachnoid Hemorrhage |
title_short |
Secondary White Matter Injury and Therapeutic Targets After Subarachnoid Hemorrhage |
title_full |
Secondary White Matter Injury and Therapeutic Targets After Subarachnoid Hemorrhage |
title_fullStr |
Secondary White Matter Injury and Therapeutic Targets After Subarachnoid Hemorrhage |
title_full_unstemmed |
Secondary White Matter Injury and Therapeutic Targets After Subarachnoid Hemorrhage |
title_sort |
secondary white matter injury and therapeutic targets after subarachnoid hemorrhage |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Neurology |
issn |
1664-2295 |
publishDate |
2021-07-01 |
description |
Aneurysmal subarachnoid hemorrhage (SAH) is one of the special stroke subtypes with high mortality and mobility. Although the mortality of SAH has decreased by 50% over the past two decades due to advances in neurosurgery and management of neurocritical care, more than 70% of survivors suffer from varying degrees of neurological deficits and cognitive impairments, leaving a heavy burden on individuals, families, and the society. Recent studies have shown that white matter is vulnerable to SAH, and white matter injuries may be one of the causes of long-term neurological deficits caused by SAH. Attention has recently focused on the pivotal role of white matter injury in the pathophysiological processes after SAH, mainly related to mechanical damage caused by increased intracerebral pressure and the metabolic damage induced by blood degradation and hypoxia. In the present review, we sought to summarize the pathophysiology processes and mechanisms of white matter injury after SAH, with a view to providing new strategies for the prevention and treatment of long-term cognitive dysfunction after SAH. |
topic |
subarachnoid hemorrhage white matter injury oligodendrocyte diffusion tensor imaging therapeutic targets |
url |
https://www.frontiersin.org/articles/10.3389/fneur.2021.659740/full |
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