Sixteen New Prenylated Flavonoids from the Fruit of Sinopodophyllum hexandrum

Sixteen new prenylated flavonoids, sinoflavonoids P−Z (1−11) and sinoflavonoids NA−NE (12−16), were isolated from the fruit of Sinopodophyllum hexandrum, along with...

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Main Authors:	Yanjun Sun, Haojie Chen, Junmin Wang, Meiling Gao, Chen Zhao, Ruijie Han, Hui Chen, Meng Li, Guimin Xue, Weisheng Feng
Format:	Article
Language:	English
Published:	MDPI AG 2019-09-01
Series:	Molecules
Subjects:	<i>Sinopodophyllum hexandrum</i> prenylated flavonoid cytotoxic activity
Online Access:	https://www.mdpi.com/1420-3049/24/17/3196

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spelling	doaj-ad09503bf0904b93b3ac0d7b2115128a2020-11-25T02:44:23ZengMDPI AGMolecules1420-30492019-09-012417319610.3390/molecules24173196molecules24173196Sixteen New Prenylated Flavonoids from the Fruit of <i>Sinopodophyllum hexandrum</i>Yanjun Sun0Haojie Chen1Junmin Wang2Meiling Gao3Chen Zhao4Ruijie Han5Hui Chen6Meng Li7Guimin Xue8Weisheng Feng9Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & Chinese Medicine, Development of Henan Province, Henan University of Chinese Medicine, Zhengzhou 450046, ChinaCollaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & Chinese Medicine, Development of Henan Province, Henan University of Chinese Medicine, Zhengzhou 450046, ChinaCollaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & Chinese Medicine, Development of Henan Province, Henan University of Chinese Medicine, Zhengzhou 450046, ChinaCollaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & Chinese Medicine, Development of Henan Province, Henan University of Chinese Medicine, Zhengzhou 450046, ChinaCollaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & Chinese Medicine, Development of Henan Province, Henan University of Chinese Medicine, Zhengzhou 450046, ChinaCollaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & Chinese Medicine, Development of Henan Province, Henan University of Chinese Medicine, Zhengzhou 450046, ChinaCollaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & Chinese Medicine, Development of Henan Province, Henan University of Chinese Medicine, Zhengzhou 450046, ChinaCollaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & Chinese Medicine, Development of Henan Province, Henan University of Chinese Medicine, Zhengzhou 450046, ChinaCollaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & Chinese Medicine, Development of Henan Province, Henan University of Chinese Medicine, Zhengzhou 450046, ChinaCollaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & Chinese Medicine, Development of Henan Province, Henan University of Chinese Medicine, Zhengzhou 450046, ChinaSixteen new prenylated flavonoids, sinoflavonoids P−Z (<b>1</b>−<b>11</b>) and sinoflavonoids NA−NE (<b>12</b>−<b>16</b>), were isolated from the fruit of <i>Sinopodophyllum hexandrum</i>, along with eight known analogues (<b>17</b>−<b>24</b>). Their structures were elucidated on the basis of extensive spectroscopic data (HR-ESI-MS, <sup>1</sup>H-NMR, <sup>13</sup>C-NMR, HSQC, HMBC). The cytotoxic activities of compounds <b>1</b>−<b>18</b>, <b>20</b>, and <b>22</b> were evaluated by MTT assay. Compound <b>6</b> showed the most potent cytotoxicity in MCF-7, and HepG2 cell lines, with IC<sub>50</sub> values of 6.25 and 3.83 μM, respectively.https://www.mdpi.com/1420-3049/24/17/3196<i>Sinopodophyllum hexandrum</i>prenylated flavonoidcytotoxic activity
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Yanjun Sun Haojie Chen Junmin Wang Meiling Gao Chen Zhao Ruijie Han Hui Chen Meng Li Guimin Xue Weisheng Feng
spellingShingle	Yanjun Sun Haojie Chen Junmin Wang Meiling Gao Chen Zhao Ruijie Han Hui Chen Meng Li Guimin Xue Weisheng Feng Sixteen New Prenylated Flavonoids from the Fruit of <i>Sinopodophyllum hexandrum</i> Molecules <i>Sinopodophyllum hexandrum</i> prenylated flavonoid cytotoxic activity
author_facet	Yanjun Sun Haojie Chen Junmin Wang Meiling Gao Chen Zhao Ruijie Han Hui Chen Meng Li Guimin Xue Weisheng Feng
author_sort	Yanjun Sun
title	Sixteen New Prenylated Flavonoids from the Fruit of <i>Sinopodophyllum hexandrum</i>
title_short	Sixteen New Prenylated Flavonoids from the Fruit of <i>Sinopodophyllum hexandrum</i>
title_full	Sixteen New Prenylated Flavonoids from the Fruit of <i>Sinopodophyllum hexandrum</i>
title_fullStr	Sixteen New Prenylated Flavonoids from the Fruit of <i>Sinopodophyllum hexandrum</i>
title_full_unstemmed	Sixteen New Prenylated Flavonoids from the Fruit of <i>Sinopodophyllum hexandrum</i>
title_sort	sixteen new prenylated flavonoids from the fruit of <i>sinopodophyllum hexandrum</i>
publisher	MDPI AG
series	Molecules
issn	1420-3049
publishDate	2019-09-01
description	Sixteen new prenylated flavonoids, sinoflavonoids P−Z (<b>1</b>−<b>11</b>) and sinoflavonoids NA−NE (<b>12</b>−<b>16</b>), were isolated from the fruit of <i>Sinopodophyllum hexandrum</i>, along with eight known analogues (<b>17</b>−<b>24</b>). Their structures were elucidated on the basis of extensive spectroscopic data (HR-ESI-MS, <sup>1</sup>H-NMR, <sup>13</sup>C-NMR, HSQC, HMBC). The cytotoxic activities of compounds <b>1</b>−<b>18</b>, <b>20</b>, and <b>22</b> were evaluated by MTT assay. Compound <b>6</b> showed the most potent cytotoxicity in MCF-7, and HepG2 cell lines, with IC<sub>50</sub> values of 6.25 and 3.83 μM, respectively.
topic	<i>Sinopodophyllum hexandrum</i> prenylated flavonoid cytotoxic activity
url	https://www.mdpi.com/1420-3049/24/17/3196
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Sixteen New Prenylated Flavonoids from the Fruit of <i>Sinopodophyllum hexandrum</i>

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