Ultrasound assessment of vasodilatory endothelial reactions in patients with Type 2 diabetes mellitus, associated with coronary heart disease and arterial hypertension

Aim. To assess heterogeneous vasodilatation mechanisms in coronary heart disease (CHD) patients with Type 2 diabetes mellitus (DM2) and arterial hypertension (AH). Material and methods. In total, 62 DM2 patients aged 41-60 years were examined. By DM2 compensation, all participants were divided into...

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Main Authors: Ya. V. Evseeva, T. E. Kurilskaya, A. A. Runovich
Format: Article
Language:Russian
Published: «SILICEA-POLIGRAF» LLC 2005-12-01
Series:Кардиоваскулярная терапия и профилактика
Subjects:
Online Access:https://cardiovascular.elpub.ru/jour/article/view/1046
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spelling doaj-ad10d3fdd0e6416db168d2e0a2eb4aab2021-07-28T13:50:42Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01252005-12-0146, ч.II8791759Ultrasound assessment of vasodilatory endothelial reactions in patients with Type 2 diabetes mellitus, associated with coronary heart disease and arterial hypertensionYa. V. Evseeva0T. E. Kurilskaya1A. A. Runovich2Reconstructive and Reparatory Surgery Research Center, East Siberian Scientific Center, Siberian Branch, Russian Academy of Medical Science, IrkutskReconstructive and Reparatory Surgery Research Center, East Siberian Scientific Center, Siberian Branch, Russian Academy of Medical Science, IrkutskReconstructive and Reparatory Surgery Research Center, East Siberian Scientific Center, Siberian Branch, Russian Academy of Medical Science, IrkutskAim. To assess heterogeneous vasodilatation mechanisms in coronary heart disease (CHD) patients with Type 2 diabetes mellitus (DM2) and arterial hypertension (AH). Material and methods. In total, 62 DM2 patients aged 41-60 years were examined. By DM2 compensation, all participants were divided into two groups: Group I (n=37) with compensated DM2, and Group 2 (n=25) with DM2 decompensation. Age- and gender-matched control group consisted of 30 relatively healthy volunteers. Endothelium-dependent vasodilatation (EDVD) of brachial artery (BA) was measured by ultrasound scanning and flow dopplerography, in reactive hyperemia test. Shear stress and endothelium sensitivity to shear stress were calculated. Endothelium-independent vasodilatation (EIVD) was assessed in sublingual nitroglycerin test. Results. In decompensated DM2 patients, even at rest, BA blood flow and elasticity were reduced. In Celermajer D.S. test, BA diameter increase was twice as low as in healthy individuals. Shear stress endothelial sensitivity was reduced in DM2 participants. In diabetic patients with carotid atherosclerosis, BA diameter increase in nitroglycerine test was significantly lower than in participants without peripheral artery atherosclerosis. Conclusion. In DM2 patients, atherogenic lipid metabolism disturbances resulted in reduced endothelial sensitivity to shear stress, and endothelial dysfunction in middle-size arteries. In inadequate hyperglycemia compensation, endothelial dysfunction was observed more often.https://cardiovascular.elpub.ru/jour/article/view/1046endothelium-independent and endothelium-dependent vasodilatationdiabetes mellitus
collection DOAJ
language Russian
format Article
sources DOAJ
author Ya. V. Evseeva
T. E. Kurilskaya
A. A. Runovich
spellingShingle Ya. V. Evseeva
T. E. Kurilskaya
A. A. Runovich
Ultrasound assessment of vasodilatory endothelial reactions in patients with Type 2 diabetes mellitus, associated with coronary heart disease and arterial hypertension
Кардиоваскулярная терапия и профилактика
endothelium-independent and endothelium-dependent vasodilatation
diabetes mellitus
author_facet Ya. V. Evseeva
T. E. Kurilskaya
A. A. Runovich
author_sort Ya. V. Evseeva
title Ultrasound assessment of vasodilatory endothelial reactions in patients with Type 2 diabetes mellitus, associated with coronary heart disease and arterial hypertension
title_short Ultrasound assessment of vasodilatory endothelial reactions in patients with Type 2 diabetes mellitus, associated with coronary heart disease and arterial hypertension
title_full Ultrasound assessment of vasodilatory endothelial reactions in patients with Type 2 diabetes mellitus, associated with coronary heart disease and arterial hypertension
title_fullStr Ultrasound assessment of vasodilatory endothelial reactions in patients with Type 2 diabetes mellitus, associated with coronary heart disease and arterial hypertension
title_full_unstemmed Ultrasound assessment of vasodilatory endothelial reactions in patients with Type 2 diabetes mellitus, associated with coronary heart disease and arterial hypertension
title_sort ultrasound assessment of vasodilatory endothelial reactions in patients with type 2 diabetes mellitus, associated with coronary heart disease and arterial hypertension
publisher «SILICEA-POLIGRAF» LLC
series Кардиоваскулярная терапия и профилактика
issn 1728-8800
2619-0125
publishDate 2005-12-01
description Aim. To assess heterogeneous vasodilatation mechanisms in coronary heart disease (CHD) patients with Type 2 diabetes mellitus (DM2) and arterial hypertension (AH). Material and methods. In total, 62 DM2 patients aged 41-60 years were examined. By DM2 compensation, all participants were divided into two groups: Group I (n=37) with compensated DM2, and Group 2 (n=25) with DM2 decompensation. Age- and gender-matched control group consisted of 30 relatively healthy volunteers. Endothelium-dependent vasodilatation (EDVD) of brachial artery (BA) was measured by ultrasound scanning and flow dopplerography, in reactive hyperemia test. Shear stress and endothelium sensitivity to shear stress were calculated. Endothelium-independent vasodilatation (EIVD) was assessed in sublingual nitroglycerin test. Results. In decompensated DM2 patients, even at rest, BA blood flow and elasticity were reduced. In Celermajer D.S. test, BA diameter increase was twice as low as in healthy individuals. Shear stress endothelial sensitivity was reduced in DM2 participants. In diabetic patients with carotid atherosclerosis, BA diameter increase in nitroglycerine test was significantly lower than in participants without peripheral artery atherosclerosis. Conclusion. In DM2 patients, atherogenic lipid metabolism disturbances resulted in reduced endothelial sensitivity to shear stress, and endothelial dysfunction in middle-size arteries. In inadequate hyperglycemia compensation, endothelial dysfunction was observed more often.
topic endothelium-independent and endothelium-dependent vasodilatation
diabetes mellitus
url https://cardiovascular.elpub.ru/jour/article/view/1046
work_keys_str_mv AT yavevseeva ultrasoundassessmentofvasodilatoryendothelialreactionsinpatientswithtype2diabetesmellitusassociatedwithcoronaryheartdiseaseandarterialhypertension
AT tekurilskaya ultrasoundassessmentofvasodilatoryendothelialreactionsinpatientswithtype2diabetesmellitusassociatedwithcoronaryheartdiseaseandarterialhypertension
AT aarunovich ultrasoundassessmentofvasodilatoryendothelialreactionsinpatientswithtype2diabetesmellitusassociatedwithcoronaryheartdiseaseandarterialhypertension
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