Bone histomorphometry in the evaluation of osteomalacia
With the widespread use of measurement of bone mineral density to detect, diagnose, and monitor therapy in the management of osteoporosis, bone histomorphometry has largely been relegated to research settings and academic pursuits. However, bone density measurement cannot distinguish between osteopo...
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doaj-ad1ba1a09cc04aa8835c922851fdee582020-11-24T21:08:00ZengElsevierBone Reports2352-18722018-06-018125134Bone histomorphometry in the evaluation of osteomalaciaArti Bhan0Shijing Qiu1Sudhaker D. Rao2Division of Endocrinology, Diabetes, and Bone & Mineral Disorders, Henry Ford Health System, Detroit, MI, 48201, United StatesBone & Mineral Research Laboratory, Henry Ford Health System, Detroit, MI, 48201, United StatesBone & Mineral Research Laboratory, Henry Ford Health System, Detroit, MI, 48201, United States; Corresponding author at: Henry Ford Medical Center, New Center One, 3031 W. Grand Blvd; Suite # 800, Detroit, MI, 48202, United States.With the widespread use of measurement of bone mineral density to detect, diagnose, and monitor therapy in the management of osteoporosis, bone histomorphometry has largely been relegated to research settings and academic pursuits. However, bone density measurement cannot distinguish between osteoporosis and other metabolic bone disorders such as different types of osteomalacia, osteitis fibrosa, renal osteodystrophy, hypophosphatasia, and Paget’s disease of bone. Furthermore, bone density test cannot tell us anything about microarchitecture of bone, tissue level dynamics, bone cellular activity, bone mineralization and bone remodeling, understanding of which is essential to make a specific diagnosis of a suspected metabolic bone disease, to evaluate beneficial (or adverse) effects of various therapies, treatment (medical or surgical) decisions in hyperparathyroid states. As a research tool, bone histomorphometry contributed immensely to our understanding of bone biology, revolutionized the study of the mechanism of actions of various therapies, and provided crucial understanding of the adverse effects of drugs. Keywords: Osteomalacia, Osteoid, Mineralization defect, Bone remodeling, Vitamin D deficiency, Tumor induced osteomalacia, Hereditary hypophosphatemic osteomalaciahttp://www.sciencedirect.com/science/article/pii/S2352187218300160 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Arti Bhan Shijing Qiu Sudhaker D. Rao |
spellingShingle |
Arti Bhan Shijing Qiu Sudhaker D. Rao Bone histomorphometry in the evaluation of osteomalacia Bone Reports |
author_facet |
Arti Bhan Shijing Qiu Sudhaker D. Rao |
author_sort |
Arti Bhan |
title |
Bone histomorphometry in the evaluation of osteomalacia |
title_short |
Bone histomorphometry in the evaluation of osteomalacia |
title_full |
Bone histomorphometry in the evaluation of osteomalacia |
title_fullStr |
Bone histomorphometry in the evaluation of osteomalacia |
title_full_unstemmed |
Bone histomorphometry in the evaluation of osteomalacia |
title_sort |
bone histomorphometry in the evaluation of osteomalacia |
publisher |
Elsevier |
series |
Bone Reports |
issn |
2352-1872 |
publishDate |
2018-06-01 |
description |
With the widespread use of measurement of bone mineral density to detect, diagnose, and monitor therapy in the management of osteoporosis, bone histomorphometry has largely been relegated to research settings and academic pursuits. However, bone density measurement cannot distinguish between osteoporosis and other metabolic bone disorders such as different types of osteomalacia, osteitis fibrosa, renal osteodystrophy, hypophosphatasia, and Paget’s disease of bone. Furthermore, bone density test cannot tell us anything about microarchitecture of bone, tissue level dynamics, bone cellular activity, bone mineralization and bone remodeling, understanding of which is essential to make a specific diagnosis of a suspected metabolic bone disease, to evaluate beneficial (or adverse) effects of various therapies, treatment (medical or surgical) decisions in hyperparathyroid states. As a research tool, bone histomorphometry contributed immensely to our understanding of bone biology, revolutionized the study of the mechanism of actions of various therapies, and provided crucial understanding of the adverse effects of drugs. Keywords: Osteomalacia, Osteoid, Mineralization defect, Bone remodeling, Vitamin D deficiency, Tumor induced osteomalacia, Hereditary hypophosphatemic osteomalacia |
url |
http://www.sciencedirect.com/science/article/pii/S2352187218300160 |
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AT artibhan bonehistomorphometryintheevaluationofosteomalacia AT shijingqiu bonehistomorphometryintheevaluationofosteomalacia AT sudhakerdrao bonehistomorphometryintheevaluationofosteomalacia |
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