How is the evolution of tumour resistance at organ-scale impacted by the importance of the organ for fitness?
Abstract Background A strong variability in cancer incidence is observed between human organs. Recently, it has been suggested that the relative contribution of organs to organism fitness (reproduction or survival) could explain at least a part of the observed variation. The objective of this study...
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doaj-ad1f6e80b9bb47d8b6f9c1a2a703ea0c2021-09-02T03:30:18ZengBMCBMC Evolutionary Biology1471-21482018-12-0118111010.1186/s12862-018-1298-7How is the evolution of tumour resistance at organ-scale impacted by the importance of the organ for fitness?Cindy Gidoin0Beata Ujvari1Frédéric Thomas2Benjamin Roche3Centre for Ecological and Evolutionary Research on Cancer (CREEC), MIVEGEC, IRD, CNRS, Univ. MontpellierCentre for Integrative Ecology, School of Life and Environmental Sciences, Deakin UniversityCentre for Ecological and Evolutionary Research on Cancer (CREEC), MIVEGEC, IRD, CNRS, Univ. MontpellierCentre for Ecological and Evolutionary Research on Cancer (CREEC), MIVEGEC, IRD, CNRS, Univ. MontpellierAbstract Background A strong variability in cancer incidence is observed between human organs. Recently, it has been suggested that the relative contribution of organs to organism fitness (reproduction or survival) could explain at least a part of the observed variation. The objective of this study is to investigate theoretically the main factors driving the evolution of tumour resistance mechanisms of organs when their relative contribution to organism fitness is considered. We use a population-scale model where individuals can develop a tumour in a key organ (i.e. in which even a small tumour can negatively impact organism fitness), an auxiliary organ (i.e. in which only a large tumour has a relatively significant impact) or both organs because of metastasis. Results Our simulations show that natural selection acts in two different ways to prevent cancer in a key and an auxiliary organs. In the key organ, the strategy mostly selected is the highest resistance and only a high cost of resistance mitigates this behavior. Inversely, we observe that a low resistance strategy can be selected in the auxiliary organ when the development of the tumour is slow and the effect of a large tumour on the mortality of the organism is relatively weak. Nevertheless, if the tumour can spread to a key organ, higher resistance strategies are selected in the auxiliary organ. Conclusion Finally, our study demonstrates that the relative contribution of organs to the organism fitness and the metastatic propensity of the tumour influence the evolution of tumour resistance at organ scale and should be considered by studies aiming to explain the variability in cancer incidence at organ-scale.http://link.springer.com/article/10.1186/s12862-018-1298-7Trade-offMetastasisCancer riskTumorigenesis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Cindy Gidoin Beata Ujvari Frédéric Thomas Benjamin Roche |
spellingShingle |
Cindy Gidoin Beata Ujvari Frédéric Thomas Benjamin Roche How is the evolution of tumour resistance at organ-scale impacted by the importance of the organ for fitness? BMC Evolutionary Biology Trade-off Metastasis Cancer risk Tumorigenesis |
author_facet |
Cindy Gidoin Beata Ujvari Frédéric Thomas Benjamin Roche |
author_sort |
Cindy Gidoin |
title |
How is the evolution of tumour resistance at organ-scale impacted by the importance of the organ for fitness? |
title_short |
How is the evolution of tumour resistance at organ-scale impacted by the importance of the organ for fitness? |
title_full |
How is the evolution of tumour resistance at organ-scale impacted by the importance of the organ for fitness? |
title_fullStr |
How is the evolution of tumour resistance at organ-scale impacted by the importance of the organ for fitness? |
title_full_unstemmed |
How is the evolution of tumour resistance at organ-scale impacted by the importance of the organ for fitness? |
title_sort |
how is the evolution of tumour resistance at organ-scale impacted by the importance of the organ for fitness? |
publisher |
BMC |
series |
BMC Evolutionary Biology |
issn |
1471-2148 |
publishDate |
2018-12-01 |
description |
Abstract Background A strong variability in cancer incidence is observed between human organs. Recently, it has been suggested that the relative contribution of organs to organism fitness (reproduction or survival) could explain at least a part of the observed variation. The objective of this study is to investigate theoretically the main factors driving the evolution of tumour resistance mechanisms of organs when their relative contribution to organism fitness is considered. We use a population-scale model where individuals can develop a tumour in a key organ (i.e. in which even a small tumour can negatively impact organism fitness), an auxiliary organ (i.e. in which only a large tumour has a relatively significant impact) or both organs because of metastasis. Results Our simulations show that natural selection acts in two different ways to prevent cancer in a key and an auxiliary organs. In the key organ, the strategy mostly selected is the highest resistance and only a high cost of resistance mitigates this behavior. Inversely, we observe that a low resistance strategy can be selected in the auxiliary organ when the development of the tumour is slow and the effect of a large tumour on the mortality of the organism is relatively weak. Nevertheless, if the tumour can spread to a key organ, higher resistance strategies are selected in the auxiliary organ. Conclusion Finally, our study demonstrates that the relative contribution of organs to the organism fitness and the metastatic propensity of the tumour influence the evolution of tumour resistance at organ scale and should be considered by studies aiming to explain the variability in cancer incidence at organ-scale. |
topic |
Trade-off Metastasis Cancer risk Tumorigenesis |
url |
http://link.springer.com/article/10.1186/s12862-018-1298-7 |
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