Phosphatidylinositol 3-kinase mediates bronchioalveolar stem cell expansion in mouse models of oncogenic K-ras-induced lung cancer.

Phosphatidylinositol 3-kinase mediates bronchioalveolar stem cell expansion in mouse models of oncogenic K-ras-induced lung cancer.

Non-small cell lung cancer (NSCLC) is the most common cause of cancer-related death in Western countries. Developing more effective NSCLC therapeutics will require the elucidation of the genetic and biochemical bases for this disease. Bronchioalveolar stem cells (BASCs) are a putative cancer stem ce...

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Bibliographic Details
Main Authors: Yanan Yang, Kentaro Iwanaga, Maria Gabriela Raso, Marie Wislez, Amy E Hanna, Eric D Wieder, Jeffrey J Molldrem, Ignacio I Wistuba, Garth Powis, Francesco J Demayo, Carla F Kim, Jonathan M Kurie
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-05-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2376060?pdf=render

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