Body composition and lipodystrophy in prepubertal HIV-infected children
Objective: To identify lipodystrophy in prepubertal HIV-infected children using anthropometric parameters and body composition assessment. Methods: Cross-sectional study including 40 prepubertal HIV-infected children of both genders seen at the Care Center of the Division of Pediatric Infectious Dis...
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doaj-ad4261c58d5c4e9c82078afc5dc8becb2020-11-25T03:24:20ZengElsevierBrazilian Journal of Infectious Diseases1413-86702013-01-0117116Body composition and lipodystrophy in prepubertal HIV-infected childrenCecilia Zanin Palchetti0Rose Vega Patin1Aída de Fátima Thomé Barbosa Gouvêa2Vera Lúcia Szejnfeld3Regina Célia de Menezes Succi4Fernanda Luisa Ceragioli Oliveira5Universidade Federal de São Paulo, Escola Paulista de Medicina, São Paulo, SP, BrazilUniversidade Federal de São Paulo, Escola Paulista de Medicina, São Paulo, SP, BrazilUniversidade Federal de São Paulo, Escola Paulista de Medicina, São Paulo, SP, BrazilUniversidade Federal de São Paulo, Escola Paulista de Medicina, São Paulo, SP, BrazilUniversidade Federal de São Paulo, Escola Paulista de Medicina, São Paulo, SP, BrazilCorresponding author at: UNIFESP/EPM, Departamento de Pediatria, Rua Loefgreen, 1647, 04040-032, São Paulo, SP, Brazil.; Universidade Federal de São Paulo, Escola Paulista de Medicina, São Paulo, SP, BrazilObjective: To identify lipodystrophy in prepubertal HIV-infected children using anthropometric parameters and body composition assessment. Methods: Cross-sectional study including 40 prepubertal HIV-infected children of both genders seen at the Care Center of the Division of Pediatric Infectious Diseases – Universidade Federal de São Paulo, São Paulo city, Brazil, was carried out from August to December 2008. Age, clinical and immunological status, prophylaxis, transmission and highly active antiretroviral therapy were recorded. Body mass index z-score and height-for-age z-score were calculated to characterize the nutritional status. Circumferences were measured with flexible tape and skinfolds were assessed by an adipometry. Fat mass and lean mass were determined by dual-energy X-ray absorptiometry. Presence of clinical signs of lipodystrophy was assessed by a trained clinician. Data were analyzed using SPSS 12.0 software. Results: The mean age and standard deviation were 9.8 (1.2) years, 50% were girls and 82.5% children from B and C categories. Clinical lipodystrophy and dislypidemia were present in 27.5% and 70%, respectively. The trunk to arm ratio and the limb to trunk ratio had positive association with lipodystrophy. Patients with lipodystrophy had short stature, higher triglycerides values and lower HDL-cholesterol. Conclusion: The ratios obtained by skinfolds and dual-energy X-ray absorptiometry measurements can be considered as indicators of preclinical lipodystrophy. The cutoff points have not been determined yet; however, continuous assessment may be useful to identify early body composition changes. Keywords: HIV, Child, Lipodystrophy, Body composition, Anthropometryhttp://www.sciencedirect.com/science/article/pii/S1413867012002772 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Cecilia Zanin Palchetti Rose Vega Patin Aída de Fátima Thomé Barbosa Gouvêa Vera Lúcia Szejnfeld Regina Célia de Menezes Succi Fernanda Luisa Ceragioli Oliveira |
spellingShingle |
Cecilia Zanin Palchetti Rose Vega Patin Aída de Fátima Thomé Barbosa Gouvêa Vera Lúcia Szejnfeld Regina Célia de Menezes Succi Fernanda Luisa Ceragioli Oliveira Body composition and lipodystrophy in prepubertal HIV-infected children Brazilian Journal of Infectious Diseases |
author_facet |
Cecilia Zanin Palchetti Rose Vega Patin Aída de Fátima Thomé Barbosa Gouvêa Vera Lúcia Szejnfeld Regina Célia de Menezes Succi Fernanda Luisa Ceragioli Oliveira |
author_sort |
Cecilia Zanin Palchetti |
title |
Body composition and lipodystrophy in prepubertal HIV-infected children |
title_short |
Body composition and lipodystrophy in prepubertal HIV-infected children |
title_full |
Body composition and lipodystrophy in prepubertal HIV-infected children |
title_fullStr |
Body composition and lipodystrophy in prepubertal HIV-infected children |
title_full_unstemmed |
Body composition and lipodystrophy in prepubertal HIV-infected children |
title_sort |
body composition and lipodystrophy in prepubertal hiv-infected children |
publisher |
Elsevier |
series |
Brazilian Journal of Infectious Diseases |
issn |
1413-8670 |
publishDate |
2013-01-01 |
description |
Objective: To identify lipodystrophy in prepubertal HIV-infected children using anthropometric parameters and body composition assessment. Methods: Cross-sectional study including 40 prepubertal HIV-infected children of both genders seen at the Care Center of the Division of Pediatric Infectious Diseases – Universidade Federal de São Paulo, São Paulo city, Brazil, was carried out from August to December 2008. Age, clinical and immunological status, prophylaxis, transmission and highly active antiretroviral therapy were recorded. Body mass index z-score and height-for-age z-score were calculated to characterize the nutritional status. Circumferences were measured with flexible tape and skinfolds were assessed by an adipometry. Fat mass and lean mass were determined by dual-energy X-ray absorptiometry. Presence of clinical signs of lipodystrophy was assessed by a trained clinician. Data were analyzed using SPSS 12.0 software. Results: The mean age and standard deviation were 9.8 (1.2) years, 50% were girls and 82.5% children from B and C categories. Clinical lipodystrophy and dislypidemia were present in 27.5% and 70%, respectively. The trunk to arm ratio and the limb to trunk ratio had positive association with lipodystrophy. Patients with lipodystrophy had short stature, higher triglycerides values and lower HDL-cholesterol. Conclusion: The ratios obtained by skinfolds and dual-energy X-ray absorptiometry measurements can be considered as indicators of preclinical lipodystrophy. The cutoff points have not been determined yet; however, continuous assessment may be useful to identify early body composition changes. Keywords: HIV, Child, Lipodystrophy, Body composition, Anthropometry |
url |
http://www.sciencedirect.com/science/article/pii/S1413867012002772 |
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