IL-20 bone diseases involvement and therapeutic target potential
Abstract Background Millions of people around the world suffer from bone disorders, likes osteoporosis, rheumatoid arthritis (RA), and cancer-induced osteolysis. In general, the bone remodeling balance is determined by osteoclasts and osteoblasts, respectively responsible for bone resorption and bon...
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doaj-ad54a03d38e64f58a988ff66844451e02020-11-24T21:05:40ZengBMCJournal of Biomedical Science1423-01272018-04-0125111010.1186/s12929-018-0439-zIL-20 bone diseases involvement and therapeutic target potentialHsiao-Hsuan Wang0Yu-Hsiang Hsu1Ming-Shi Chang2Institute of Basic Medical Sciences, National Cheng Kung UniversityInstitute of Clinical Medicine, National Cheng Kung UniversityInstitute of Basic Medical Sciences, National Cheng Kung UniversityAbstract Background Millions of people around the world suffer from bone disorders, likes osteoporosis, rheumatoid arthritis (RA), and cancer-induced osteolysis. In general, the bone remodeling balance is determined by osteoclasts and osteoblasts, respectively responsible for bone resorption and bone formation. Excessive inflammation disturbs the activities of these two kinds of cells, typically resulting in the bone loss. Main body IL-20 is emerging as a potent angiogenic, chemotactic, and proinflammatory cytokine related to several chronic inflammatory disorders likes psoriasis, atherosclerosis, cancer, liver fibrosis, and RA. IL-20 has an important role in the regulation of osteoclastogenesis and osteoblastogenesis and is upregulated in several bone-related diseases. The anti-IL-20 monoclonal antibody treatment has a therapeutic potential in several experimental disease models including ovariectomy-induced osteoporosis, cancer-induced osteolysis, and bone fracture. Conclusion This review article provides an overview describing the IL-20’s biological functions in the common bone disorders and thus providing a novel therapeutic strategy in the future.http://link.springer.com/article/10.1186/s12929-018-0439-zIL-20Bone homeostasisRheumatoid arthritisOsteoporosisCancer-induced osteolysisBone fracture |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hsiao-Hsuan Wang Yu-Hsiang Hsu Ming-Shi Chang |
spellingShingle |
Hsiao-Hsuan Wang Yu-Hsiang Hsu Ming-Shi Chang IL-20 bone diseases involvement and therapeutic target potential Journal of Biomedical Science IL-20 Bone homeostasis Rheumatoid arthritis Osteoporosis Cancer-induced osteolysis Bone fracture |
author_facet |
Hsiao-Hsuan Wang Yu-Hsiang Hsu Ming-Shi Chang |
author_sort |
Hsiao-Hsuan Wang |
title |
IL-20 bone diseases involvement and therapeutic target potential |
title_short |
IL-20 bone diseases involvement and therapeutic target potential |
title_full |
IL-20 bone diseases involvement and therapeutic target potential |
title_fullStr |
IL-20 bone diseases involvement and therapeutic target potential |
title_full_unstemmed |
IL-20 bone diseases involvement and therapeutic target potential |
title_sort |
il-20 bone diseases involvement and therapeutic target potential |
publisher |
BMC |
series |
Journal of Biomedical Science |
issn |
1423-0127 |
publishDate |
2018-04-01 |
description |
Abstract Background Millions of people around the world suffer from bone disorders, likes osteoporosis, rheumatoid arthritis (RA), and cancer-induced osteolysis. In general, the bone remodeling balance is determined by osteoclasts and osteoblasts, respectively responsible for bone resorption and bone formation. Excessive inflammation disturbs the activities of these two kinds of cells, typically resulting in the bone loss. Main body IL-20 is emerging as a potent angiogenic, chemotactic, and proinflammatory cytokine related to several chronic inflammatory disorders likes psoriasis, atherosclerosis, cancer, liver fibrosis, and RA. IL-20 has an important role in the regulation of osteoclastogenesis and osteoblastogenesis and is upregulated in several bone-related diseases. The anti-IL-20 monoclonal antibody treatment has a therapeutic potential in several experimental disease models including ovariectomy-induced osteoporosis, cancer-induced osteolysis, and bone fracture. Conclusion This review article provides an overview describing the IL-20’s biological functions in the common bone disorders and thus providing a novel therapeutic strategy in the future. |
topic |
IL-20 Bone homeostasis Rheumatoid arthritis Osteoporosis Cancer-induced osteolysis Bone fracture |
url |
http://link.springer.com/article/10.1186/s12929-018-0439-z |
work_keys_str_mv |
AT hsiaohsuanwang il20bonediseasesinvolvementandtherapeutictargetpotential AT yuhsianghsu il20bonediseasesinvolvementandtherapeutictargetpotential AT mingshichang il20bonediseasesinvolvementandtherapeutictargetpotential |
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1716767996787032064 |