Comprehensive investigation of HBV-related hepatocellular carcinoma and choice of anti-HBV therapy
Chronic hepatitis B virus (HBV) infection is a global public health problem, which can cause chronic hepatitis, liver cirrhosis, hepatocellular carcinoma (HCC), and other diseases. Antiviral therapy is the most critical measure to slow down the progression of chronic hepatitis B, prevent or delay ci...
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doaj-ad54f74e5321429ea4638d67492ab1cf2021-09-03T04:46:49ZengElsevierBiosafety and Health2590-05362021-08-0134190196Comprehensive investigation of HBV-related hepatocellular carcinoma and choice of anti-HBV therapyHuihui Lu0Wei Yi1Fangfang Sun2Zhan Zeng3Lu Zhang4Minghui Li5Yao Xie6Department of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, ChinaDepartment of Gynecology and Obstetrics, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, ChinaDepartment of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, ChinaDepartment of Hepatology Division 2, Peking University Ditan Teaching Hospital, Beijing 100015, ChinaDepartment of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, ChinaDepartment of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China; Department of Hepatology Division 2, Peking University Ditan Teaching Hospital, Beijing 100015, China; Corresponding authors: Department of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University; Peking University Ditan Teaching Hospital, Jing Shun Dong Jie 8#, Beijing 100015, China.Department of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China; Department of Hepatology Division 2, Peking University Ditan Teaching Hospital, Beijing 100015, China; Corresponding authors: Department of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University; Peking University Ditan Teaching Hospital, Jing Shun Dong Jie 8#, Beijing 100015, China.Chronic hepatitis B virus (HBV) infection is a global public health problem, which can cause chronic hepatitis, liver cirrhosis, hepatocellular carcinoma (HCC), and other diseases. Antiviral therapy is the most critical measure to slow down the progression of chronic hepatitis B, prevent or delay cirrhosis, HCC, and other kinds of liver decompensation events. At present, the anti-hepatitis B virus drugs are mainly nucleoside (acid) analogues (NAs) and interferon. Each kind of antiviral drug has different effects on the clinical outcome of hepatitis B patients (such as HCC). In this paper, we discussed the biological characteristics, natural course and prognosis of HBV infection, the mechanism of HBV-related HCC, the effect of different antiviral drugs on patients’ outcome, predictive biomarkers and model for HBV clinical outcome, predictors of sustained response and recurrence after withdrawal of antiviral therapy, consideration of expanding therapeutic indications and antiviral therapy, hoping to give a hand to the clinical diagnosis and treatment of HBV.http://www.sciencedirect.com/science/article/pii/S2590053621000422HBVInterferonNucleoside (acid) analogueHepatocellular carcinoma |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Huihui Lu Wei Yi Fangfang Sun Zhan Zeng Lu Zhang Minghui Li Yao Xie |
spellingShingle |
Huihui Lu Wei Yi Fangfang Sun Zhan Zeng Lu Zhang Minghui Li Yao Xie Comprehensive investigation of HBV-related hepatocellular carcinoma and choice of anti-HBV therapy Biosafety and Health HBV Interferon Nucleoside (acid) analogue Hepatocellular carcinoma |
author_facet |
Huihui Lu Wei Yi Fangfang Sun Zhan Zeng Lu Zhang Minghui Li Yao Xie |
author_sort |
Huihui Lu |
title |
Comprehensive investigation of HBV-related hepatocellular carcinoma and choice of anti-HBV therapy |
title_short |
Comprehensive investigation of HBV-related hepatocellular carcinoma and choice of anti-HBV therapy |
title_full |
Comprehensive investigation of HBV-related hepatocellular carcinoma and choice of anti-HBV therapy |
title_fullStr |
Comprehensive investigation of HBV-related hepatocellular carcinoma and choice of anti-HBV therapy |
title_full_unstemmed |
Comprehensive investigation of HBV-related hepatocellular carcinoma and choice of anti-HBV therapy |
title_sort |
comprehensive investigation of hbv-related hepatocellular carcinoma and choice of anti-hbv therapy |
publisher |
Elsevier |
series |
Biosafety and Health |
issn |
2590-0536 |
publishDate |
2021-08-01 |
description |
Chronic hepatitis B virus (HBV) infection is a global public health problem, which can cause chronic hepatitis, liver cirrhosis, hepatocellular carcinoma (HCC), and other diseases. Antiviral therapy is the most critical measure to slow down the progression of chronic hepatitis B, prevent or delay cirrhosis, HCC, and other kinds of liver decompensation events. At present, the anti-hepatitis B virus drugs are mainly nucleoside (acid) analogues (NAs) and interferon. Each kind of antiviral drug has different effects on the clinical outcome of hepatitis B patients (such as HCC). In this paper, we discussed the biological characteristics, natural course and prognosis of HBV infection, the mechanism of HBV-related HCC, the effect of different antiviral drugs on patients’ outcome, predictive biomarkers and model for HBV clinical outcome, predictors of sustained response and recurrence after withdrawal of antiviral therapy, consideration of expanding therapeutic indications and antiviral therapy, hoping to give a hand to the clinical diagnosis and treatment of HBV. |
topic |
HBV Interferon Nucleoside (acid) analogue Hepatocellular carcinoma |
url |
http://www.sciencedirect.com/science/article/pii/S2590053621000422 |
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