Thioredoxin-Interacting Protein Promotes Phagosomal Acidification Upon Exposure to Escherichia coli Through Inflammasome-Mediated Caspase-1 Activation in Macrophages

Thioredoxin-Interacting Protein Promotes Phagosomal Acidification Upon Exposure to Escherichia coli Through Inflammasome-Mediated Caspase-1 Activation in Macrophages

In host defense, it is crucial to maintain the acidity of the macrophage phagosome for effective bacterial clearance. However, the mechanisms governing phagosomal acidification upon exposure to gram-negative bacteria have not been fully elucidated. In this study, we demonstrate that in macrophages e...

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Bibliographic Details
Main Authors: Sung-Jin Yoon, Dong Hyun Jo, Seung-Ho Park, Jun-Young Park, Yoo-Kyung Lee, Moo-Seung Lee, Jeong-Ki Min, Haiyoung Jung, Tae-Don Kim, Suk Ran Yoon, Su Wol Chung, Jeong Hun Kim, Inpyo Choi, Young-Jun Park
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Immunology
Subjects:
thioredoxin-interacting protein
Escherichia coli
caspase
phagosome
macrophage
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02636/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02636/full

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