Comparative recognition by human IgG antibodies of recombinant proteins representing three asexual erythrocytic stage vaccine candidates of Plasmodium vivax
In previous immuno-epidemiological studies of the naturally acquired antibody responses to merozoite surface protein-1 (MSP-1) of Plasmodium vivax, we had evidence that the responses to distinct erythrocytic stage antigens could be differentially regulated. The present study was designed to compare...
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Instituto Oswaldo Cruz, Ministério da Saúde
2007-06-01
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doaj-ad787abe30e94f8ab6f7697f993d20e12020-11-24T21:29:43ZengInstituto Oswaldo Cruz, Ministério da SaúdeMemórias do Instituto Oswaldo Cruz.0074-02761678-80602007-06-011023335340Comparative recognition by human IgG antibodies of recombinant proteins representing three asexual erythrocytic stage vaccine candidates of Plasmodium vivaxMayara B BarbedoRicardo RicciMaria Carolina S JimenezMaristela G CunhaSyed S YazdaniChetan E ChitnisMauricio M RodriguesIrene S SoaresIn previous immuno-epidemiological studies of the naturally acquired antibody responses to merozoite surface protein-1 (MSP-1) of Plasmodium vivax, we had evidence that the responses to distinct erythrocytic stage antigens could be differentially regulated. The present study was designed to compare the antibody response to three asexual erythrocytic stage antigens vaccine candidates of P. vivax. Recombinant proteins representing the 19 kDa C-terminal region of MSP-1(PvMSP19), apical membrane antigen n-1 ectodomain (PvAMA-1), and the region II of duffy binding protein (PvDBP-RII) were compared in their ability to bind to IgG antibodies of serum samples collected from 220 individuals from the state of Pará, in the North of Brazil. During patent infection with P. vivax, the frequency of individuals with IgG antibodies to PvMSP1(19), PvAMA-1, and PvDBP-RII were 95, 72.7, and 44.5% respectively. Although the frequency of responders to PvDBP-RII was lower, this frequency increased in individuals following multiple malarial infections. Individually, the specific antibody levels did not decline significantly nine months after treatment, except to PvMSP1(19). Our results further confirm a complex regulation of the immune response to distinct blood stage antigens. The reason for that is presently unknown but it may contribute to the high risk of re-infection in individuals living in the endemic areas.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762007000300013malariaPlasmodium vivaxmerozoite antigensIgG antibody response |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mayara B Barbedo Ricardo Ricci Maria Carolina S Jimenez Maristela G Cunha Syed S Yazdani Chetan E Chitnis Mauricio M Rodrigues Irene S Soares |
spellingShingle |
Mayara B Barbedo Ricardo Ricci Maria Carolina S Jimenez Maristela G Cunha Syed S Yazdani Chetan E Chitnis Mauricio M Rodrigues Irene S Soares Comparative recognition by human IgG antibodies of recombinant proteins representing three asexual erythrocytic stage vaccine candidates of Plasmodium vivax Memórias do Instituto Oswaldo Cruz. malaria Plasmodium vivax merozoite antigens IgG antibody response |
author_facet |
Mayara B Barbedo Ricardo Ricci Maria Carolina S Jimenez Maristela G Cunha Syed S Yazdani Chetan E Chitnis Mauricio M Rodrigues Irene S Soares |
author_sort |
Mayara B Barbedo |
title |
Comparative recognition by human IgG antibodies of recombinant proteins representing three asexual erythrocytic stage vaccine candidates of Plasmodium vivax |
title_short |
Comparative recognition by human IgG antibodies of recombinant proteins representing three asexual erythrocytic stage vaccine candidates of Plasmodium vivax |
title_full |
Comparative recognition by human IgG antibodies of recombinant proteins representing three asexual erythrocytic stage vaccine candidates of Plasmodium vivax |
title_fullStr |
Comparative recognition by human IgG antibodies of recombinant proteins representing three asexual erythrocytic stage vaccine candidates of Plasmodium vivax |
title_full_unstemmed |
Comparative recognition by human IgG antibodies of recombinant proteins representing three asexual erythrocytic stage vaccine candidates of Plasmodium vivax |
title_sort |
comparative recognition by human igg antibodies of recombinant proteins representing three asexual erythrocytic stage vaccine candidates of plasmodium vivax |
publisher |
Instituto Oswaldo Cruz, Ministério da Saúde |
series |
Memórias do Instituto Oswaldo Cruz. |
issn |
0074-0276 1678-8060 |
publishDate |
2007-06-01 |
description |
In previous immuno-epidemiological studies of the naturally acquired antibody responses to merozoite surface protein-1 (MSP-1) of Plasmodium vivax, we had evidence that the responses to distinct erythrocytic stage antigens could be differentially regulated. The present study was designed to compare the antibody response to three asexual erythrocytic stage antigens vaccine candidates of P. vivax. Recombinant proteins representing the 19 kDa C-terminal region of MSP-1(PvMSP19), apical membrane antigen n-1 ectodomain (PvAMA-1), and the region II of duffy binding protein (PvDBP-RII) were compared in their ability to bind to IgG antibodies of serum samples collected from 220 individuals from the state of Pará, in the North of Brazil. During patent infection with P. vivax, the frequency of individuals with IgG antibodies to PvMSP1(19), PvAMA-1, and PvDBP-RII were 95, 72.7, and 44.5% respectively. Although the frequency of responders to PvDBP-RII was lower, this frequency increased in individuals following multiple malarial infections. Individually, the specific antibody levels did not decline significantly nine months after treatment, except to PvMSP1(19). Our results further confirm a complex regulation of the immune response to distinct blood stage antigens. The reason for that is presently unknown but it may contribute to the high risk of re-infection in individuals living in the endemic areas. |
topic |
malaria Plasmodium vivax merozoite antigens IgG antibody response |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762007000300013 |
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