Age-dependent sexual dimorphism in cognition and stress response in the 3xTg-AD mice

We sought to determine if sex impacts the cognitive and neuropathological phenotype of the 3xTg-AD mice. We find that male and female 3xTg-AD mice show comparable impairments on Morris water maze (MWM) and inhibitory avoidance (IA) at 4 months. Shortly thereafter, however, the cognitive performance...

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Main Authors:	Lani K. Clinton, Lauren M. Billings, Kim N. Green, Antonella Caccamo, Jerry Ngo, Salvatore Oddo, James L. McGaugh, Frank M. LaFerla
Format:	Article
Language:	English
Published:	Elsevier 2007-10-01
Series:	Neurobiology of Disease
Online Access:	http://www.sciencedirect.com/science/article/pii/S0969996107001350

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spelling	doaj-ad8a24e16aca4443995fe3e7e55772d22021-03-20T04:54:46ZengElsevierNeurobiology of Disease1095-953X2007-10-012817682Age-dependent sexual dimorphism in cognition and stress response in the 3xTg-AD miceLani K. Clinton0Lauren M. Billings1Kim N. Green2Antonella Caccamo3Jerry Ngo4Salvatore Oddo5James L. McGaugh6Frank M. LaFerla7Department of Neurobiology and Behavior, 1109 Gillespie Neuroscience Research Facility, University of California, Irvine, Irvine, CA 92697-4545, USADepartment of Neurobiology and Behavior, 1109 Gillespie Neuroscience Research Facility, University of California, Irvine, Irvine, CA 92697-4545, USADepartment of Neurobiology and Behavior, 1109 Gillespie Neuroscience Research Facility, University of California, Irvine, Irvine, CA 92697-4545, USADepartment of Neurobiology and Behavior, 1109 Gillespie Neuroscience Research Facility, University of California, Irvine, Irvine, CA 92697-4545, USADepartment of Neurobiology and Behavior, 1109 Gillespie Neuroscience Research Facility, University of California, Irvine, Irvine, CA 92697-4545, USADepartment of Neurobiology and Behavior, 1109 Gillespie Neuroscience Research Facility, University of California, Irvine, Irvine, CA 92697-4545, USADepartment of Neurobiology and Behavior, 1109 Gillespie Neuroscience Research Facility, University of California, Irvine, Irvine, CA 92697-4545, USACorresponding author. Fax: +1 949 824 7356.; Department of Neurobiology and Behavior, 1109 Gillespie Neuroscience Research Facility, University of California, Irvine, Irvine, CA 92697-4545, USAWe sought to determine if sex impacts the cognitive and neuropathological phenotype of the 3xTg-AD mice. We find that male and female 3xTg-AD mice show comparable impairments on Morris water maze (MWM) and inhibitory avoidance (IA) at 4 months. Shortly thereafter, however, the cognitive performance varies among the sexes, with females performing worse than males. These behavioral differences are not attributable to differences in Aβ or tau levels. The behavioral effect is transient as from 12 months onward, the disparity is no longer apparent. Because females perform worse than males on stressful tasks, we explored their corticosterone responses and find that young female 3xTg-AD mice show markedly heightened corticosterone response after 5 days of MWM training compared to age-matched male 3xTg-AD mice; this difference is no longer apparent in older mice. Thus, the enhanced corticosterone response of the young female mice likely underlies their poorer performance on stressful tasks.http://www.sciencedirect.com/science/article/pii/S0969996107001350
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Lani K. Clinton Lauren M. Billings Kim N. Green Antonella Caccamo Jerry Ngo Salvatore Oddo James L. McGaugh Frank M. LaFerla
spellingShingle	Lani K. Clinton Lauren M. Billings Kim N. Green Antonella Caccamo Jerry Ngo Salvatore Oddo James L. McGaugh Frank M. LaFerla Age-dependent sexual dimorphism in cognition and stress response in the 3xTg-AD mice Neurobiology of Disease
author_facet	Lani K. Clinton Lauren M. Billings Kim N. Green Antonella Caccamo Jerry Ngo Salvatore Oddo James L. McGaugh Frank M. LaFerla
author_sort	Lani K. Clinton
title	Age-dependent sexual dimorphism in cognition and stress response in the 3xTg-AD mice
title_short	Age-dependent sexual dimorphism in cognition and stress response in the 3xTg-AD mice
title_full	Age-dependent sexual dimorphism in cognition and stress response in the 3xTg-AD mice
title_fullStr	Age-dependent sexual dimorphism in cognition and stress response in the 3xTg-AD mice
title_full_unstemmed	Age-dependent sexual dimorphism in cognition and stress response in the 3xTg-AD mice
title_sort	age-dependent sexual dimorphism in cognition and stress response in the 3xtg-ad mice
publisher	Elsevier
series	Neurobiology of Disease
issn	1095-953X
publishDate	2007-10-01
description	We sought to determine if sex impacts the cognitive and neuropathological phenotype of the 3xTg-AD mice. We find that male and female 3xTg-AD mice show comparable impairments on Morris water maze (MWM) and inhibitory avoidance (IA) at 4 months. Shortly thereafter, however, the cognitive performance varies among the sexes, with females performing worse than males. These behavioral differences are not attributable to differences in Aβ or tau levels. The behavioral effect is transient as from 12 months onward, the disparity is no longer apparent. Because females perform worse than males on stressful tasks, we explored their corticosterone responses and find that young female 3xTg-AD mice show markedly heightened corticosterone response after 5 days of MWM training compared to age-matched male 3xTg-AD mice; this difference is no longer apparent in older mice. Thus, the enhanced corticosterone response of the young female mice likely underlies their poorer performance on stressful tasks.
url	http://www.sciencedirect.com/science/article/pii/S0969996107001350
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Age-dependent sexual dimorphism in cognition and stress response in the 3xTg-AD mice

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