Expedition into Exosome Biology: A Perspective of Progress from Discovery to Therapeutic Development
Exosomes are membrane-enclosed distinct cellular entities of endocytic origin that shuttle proteins and RNA molecules intercellularly for communication purposes. Their surface is embossed by a huge variety of proteins, some of which are used as diagnostic markers. Exosomes are being explored for pot...
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doaj-ad8d56c268494566ba6127715c9fc50d2021-03-09T00:02:38ZengMDPI AGCancers2072-66942021-03-01131157115710.3390/cancers13051157Expedition into Exosome Biology: A Perspective of Progress from Discovery to Therapeutic DevelopmentArif Tasleem Jan0Safikur Rahman1Raied Badierah2Eun Ju Lee3Ehab H. Mattar4Elrashdy M. Redwan5Inho Choi6School of Biosciences and Biotechnology, Baba Ghulam Shah Badshah University, Rajouri 185234, IndiaDepartment of Botany, MS College, BR Ambedkar Bihar University, Muzaffarpur, Bihar 842001, IndiaBiological Sciences Department, Faculty of Science, and Laboratory University Hospital, King Abdulaziz University, Jeddah, P.O. Box 80203, Saudi ArabiaDepartment of Medical Biotechnology and Research Institute of Cell Culture, Yeungnam University, Gyeongsan 38541, KoreaBiological Sciences Department, Faculty of Science, and Laboratory University Hospital, King Abdulaziz University, Jeddah, P.O. Box 80203, Saudi ArabiaBiological Sciences Department, Faculty of Science, and Laboratory University Hospital, King Abdulaziz University, Jeddah, P.O. Box 80203, Saudi ArabiaDepartment of Medical Biotechnology and Research Institute of Cell Culture, Yeungnam University, Gyeongsan 38541, KoreaExosomes are membrane-enclosed distinct cellular entities of endocytic origin that shuttle proteins and RNA molecules intercellularly for communication purposes. Their surface is embossed by a huge variety of proteins, some of which are used as diagnostic markers. Exosomes are being explored for potential drug delivery, although their therapeutic utilities are impeded by gaps in knowledge regarding their formation and function under physiological condition and by lack of methods capable of shedding light on intraluminal vesicle release at the target site. Nonetheless, exosomes offer a promising means of developing systems that enable the specific delivery of therapeutics in diseases like cancer. This review summarizes information on donor cell types, cargoes, cargo loading, routes of administration, and the engineering of exosomal surfaces for specific peptides that increase target specificity and as such, therapeutic delivery.https://www.mdpi.com/2072-6694/13/5/1157antigencancerexosomesimmune responsetherapeutics |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Arif Tasleem Jan Safikur Rahman Raied Badierah Eun Ju Lee Ehab H. Mattar Elrashdy M. Redwan Inho Choi |
spellingShingle |
Arif Tasleem Jan Safikur Rahman Raied Badierah Eun Ju Lee Ehab H. Mattar Elrashdy M. Redwan Inho Choi Expedition into Exosome Biology: A Perspective of Progress from Discovery to Therapeutic Development Cancers antigen cancer exosomes immune response therapeutics |
author_facet |
Arif Tasleem Jan Safikur Rahman Raied Badierah Eun Ju Lee Ehab H. Mattar Elrashdy M. Redwan Inho Choi |
author_sort |
Arif Tasleem Jan |
title |
Expedition into Exosome Biology: A Perspective of Progress from Discovery to Therapeutic Development |
title_short |
Expedition into Exosome Biology: A Perspective of Progress from Discovery to Therapeutic Development |
title_full |
Expedition into Exosome Biology: A Perspective of Progress from Discovery to Therapeutic Development |
title_fullStr |
Expedition into Exosome Biology: A Perspective of Progress from Discovery to Therapeutic Development |
title_full_unstemmed |
Expedition into Exosome Biology: A Perspective of Progress from Discovery to Therapeutic Development |
title_sort |
expedition into exosome biology: a perspective of progress from discovery to therapeutic development |
publisher |
MDPI AG |
series |
Cancers |
issn |
2072-6694 |
publishDate |
2021-03-01 |
description |
Exosomes are membrane-enclosed distinct cellular entities of endocytic origin that shuttle proteins and RNA molecules intercellularly for communication purposes. Their surface is embossed by a huge variety of proteins, some of which are used as diagnostic markers. Exosomes are being explored for potential drug delivery, although their therapeutic utilities are impeded by gaps in knowledge regarding their formation and function under physiological condition and by lack of methods capable of shedding light on intraluminal vesicle release at the target site. Nonetheless, exosomes offer a promising means of developing systems that enable the specific delivery of therapeutics in diseases like cancer. This review summarizes information on donor cell types, cargoes, cargo loading, routes of administration, and the engineering of exosomal surfaces for specific peptides that increase target specificity and as such, therapeutic delivery. |
topic |
antigen cancer exosomes immune response therapeutics |
url |
https://www.mdpi.com/2072-6694/13/5/1157 |
work_keys_str_mv |
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