Impairment of the transition from proliferative stage to prehypertrophic stage in chondrogenic differentiation of human induced pluripotent stem cells harboring the causative mutation of achondroplasia in fibroblast growth factor receptor 3

Impairment of the transition from proliferative stage to prehypertrophic stage in chondrogenic differentiation of human induced pluripotent stem cells harboring the causative mutation of achondroplasia in fibroblast growth factor receptor 3

Introduction: Achondroplasia (ACH) is a congenital disease which causes dwarfism and many symptoms resulting from skeletal dysplasia. Because present therapeutic strategies are mainly surgical procedures as symptomatic treatments, development of a radical treatment is desired. Clarification of the A...

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Bibliographic Details
Main Authors: Naohiro Horie, Atsuhiko Hikita, Satoru Nishizawa, Sakura Uto, Tsuyoshi Takato, Kazuto Hoshi
Format: Article
Language:English
Published: Elsevier 2017-06-01
Series:Regenerative Therapy
Subjects:
iPS cell
Achondroplasia
Genome editing
Differentiation
Chondrocyte
Online Access:http://www.sciencedirect.com/science/article/pii/S2352320416300608

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