Dietary Supplementation with a Superoxide Dismutase-Melon Concentrate Reduces Stress, Physical and Mental Fatigue in Healthy People: A Randomised, Double-Blind, Placebo-Controlled Trial
Background: We aimed to investigate effects of superoxide dismutase (SOD)-melon concentrate supplementation on psychological stress, physical and mental fatigue in healthy people. Methods: A randomized, double-blind, placebo-controlled trial was performed on 61 people divided in two groups: active...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2014-06-01
|
Series: | Nutrients |
Subjects: | |
Online Access: | http://www.mdpi.com/2072-6643/6/6/2348 |
id |
doaj-ad9293af98e7447985409e2513442a8a |
---|---|
record_format |
Article |
spelling |
doaj-ad9293af98e7447985409e2513442a8a2020-11-24T22:13:24ZengMDPI AGNutrients2072-66432014-06-01662348235910.3390/nu6062348nu6062348Dietary Supplementation with a Superoxide Dismutase-Melon Concentrate Reduces Stress, Physical and Mental Fatigue in Healthy People: A Randomised, Double-Blind, Placebo-Controlled TrialJulie Carillon0Claire Notin1Karine Schmitt2Guy Simoneau3Dominique Lacan4Bionov Company, 939 rue de la Croix Verte, Montpellier 34090, FranceSeppic Company, 22 Terasse Bellini, Puteaux 92806, FranceBionov Company, 939 rue de la Croix Verte, Montpellier 34090, FranceTherapeutic Research Unit, Department of Internal Medicine, Lariboisière Hospital, 2 rue Ambroise-Paré, Paris 75010, FranceBionov Company, 939 rue de la Croix Verte, Montpellier 34090, FranceBackground: We aimed to investigate effects of superoxide dismutase (SOD)-melon concentrate supplementation on psychological stress, physical and mental fatigue in healthy people. Methods: A randomized, double-blind, placebo-controlled trial was performed on 61 people divided in two groups: active supplement (n = 32) and placebo (n = 29) for 12 weeks. Volunteers were given one small hard capsule per day. One capsule contained 10 mg of SOD-melon concentrate (140 U of SOD) and starch for the active supplement and starch only for the placebo. Stress and fatigue were evaluated using four psychometric scales: PSS-14; SF-36; Stroop tests and Prevost scale. Results: The supplementation with SOD-melon concentrate significantly decreased perceived stress, compared to placebo. Moreover, quality of life was improved and physical and mental fatigue were reduced with SOD-melon concentrate supplementation. Conclusion: SOD-melon concentrate supplementation appears to be an effective and natural way to reduce stress and fatigue. Trial registration: trial approved by the ethical committee of Poitiers (France), and the ClinicalTrials.gov Identifier is NCT01767922.http://www.mdpi.com/2072-6643/6/6/2348psychological stressphysical and mental fatigueoxidative stressmelonsuperoxide dismutasepsychometric scales |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Julie Carillon Claire Notin Karine Schmitt Guy Simoneau Dominique Lacan |
spellingShingle |
Julie Carillon Claire Notin Karine Schmitt Guy Simoneau Dominique Lacan Dietary Supplementation with a Superoxide Dismutase-Melon Concentrate Reduces Stress, Physical and Mental Fatigue in Healthy People: A Randomised, Double-Blind, Placebo-Controlled Trial Nutrients psychological stress physical and mental fatigue oxidative stress melon superoxide dismutase psychometric scales |
author_facet |
Julie Carillon Claire Notin Karine Schmitt Guy Simoneau Dominique Lacan |
author_sort |
Julie Carillon |
title |
Dietary Supplementation with a Superoxide Dismutase-Melon Concentrate Reduces Stress, Physical and Mental Fatigue in Healthy People: A Randomised, Double-Blind, Placebo-Controlled Trial |
title_short |
Dietary Supplementation with a Superoxide Dismutase-Melon Concentrate Reduces Stress, Physical and Mental Fatigue in Healthy People: A Randomised, Double-Blind, Placebo-Controlled Trial |
title_full |
Dietary Supplementation with a Superoxide Dismutase-Melon Concentrate Reduces Stress, Physical and Mental Fatigue in Healthy People: A Randomised, Double-Blind, Placebo-Controlled Trial |
title_fullStr |
Dietary Supplementation with a Superoxide Dismutase-Melon Concentrate Reduces Stress, Physical and Mental Fatigue in Healthy People: A Randomised, Double-Blind, Placebo-Controlled Trial |
title_full_unstemmed |
Dietary Supplementation with a Superoxide Dismutase-Melon Concentrate Reduces Stress, Physical and Mental Fatigue in Healthy People: A Randomised, Double-Blind, Placebo-Controlled Trial |
title_sort |
dietary supplementation with a superoxide dismutase-melon concentrate reduces stress, physical and mental fatigue in healthy people: a randomised, double-blind, placebo-controlled trial |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2014-06-01 |
description |
Background: We aimed to investigate effects of superoxide dismutase (SOD)-melon concentrate supplementation on psychological stress, physical and mental fatigue in healthy people. Methods: A randomized, double-blind, placebo-controlled trial was performed on 61 people divided in two groups: active supplement (n = 32) and placebo (n = 29) for 12 weeks. Volunteers were given one small hard capsule per day. One capsule contained 10 mg of SOD-melon concentrate (140 U of SOD) and starch for the active supplement and starch only for the placebo. Stress and fatigue were evaluated using four psychometric scales: PSS-14; SF-36; Stroop tests and Prevost scale. Results: The supplementation with SOD-melon concentrate significantly decreased perceived stress, compared to placebo. Moreover, quality of life was improved and physical and mental fatigue were reduced with SOD-melon concentrate supplementation. Conclusion: SOD-melon concentrate supplementation appears to be an effective and natural way to reduce stress and fatigue. Trial registration: trial approved by the ethical committee of Poitiers (France), and the ClinicalTrials.gov Identifier is NCT01767922. |
topic |
psychological stress physical and mental fatigue oxidative stress melon superoxide dismutase psychometric scales |
url |
http://www.mdpi.com/2072-6643/6/6/2348 |
work_keys_str_mv |
AT juliecarillon dietarysupplementationwithasuperoxidedismutasemelonconcentratereducesstressphysicalandmentalfatigueinhealthypeoplearandomiseddoubleblindplacebocontrolledtrial AT clairenotin dietarysupplementationwithasuperoxidedismutasemelonconcentratereducesstressphysicalandmentalfatigueinhealthypeoplearandomiseddoubleblindplacebocontrolledtrial AT karineschmitt dietarysupplementationwithasuperoxidedismutasemelonconcentratereducesstressphysicalandmentalfatigueinhealthypeoplearandomiseddoubleblindplacebocontrolledtrial AT guysimoneau dietarysupplementationwithasuperoxidedismutasemelonconcentratereducesstressphysicalandmentalfatigueinhealthypeoplearandomiseddoubleblindplacebocontrolledtrial AT dominiquelacan dietarysupplementationwithasuperoxidedismutasemelonconcentratereducesstressphysicalandmentalfatigueinhealthypeoplearandomiseddoubleblindplacebocontrolledtrial |
_version_ |
1725801210282246144 |