Dietary Supplementation with a Superoxide Dismutase-Melon Concentrate Reduces Stress, Physical and Mental Fatigue in Healthy People: A Randomised, Double-Blind, Placebo-Controlled Trial

Background: We aimed to investigate effects of superoxide dismutase (SOD)-melon concentrate supplementation on psychological stress, physical and mental fatigue in healthy people. Methods: A randomized, double-blind, placebo-controlled trial was performed on 61 people divided in two groups: active...

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Main Authors: Julie Carillon, Claire Notin, Karine Schmitt, Guy Simoneau, Dominique Lacan
Format: Article
Language:English
Published: MDPI AG 2014-06-01
Series:Nutrients
Subjects:
Online Access:http://www.mdpi.com/2072-6643/6/6/2348
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spelling doaj-ad9293af98e7447985409e2513442a8a2020-11-24T22:13:24ZengMDPI AGNutrients2072-66432014-06-01662348235910.3390/nu6062348nu6062348Dietary Supplementation with a Superoxide Dismutase-Melon Concentrate Reduces Stress, Physical and Mental Fatigue in Healthy People: A Randomised, Double-Blind, Placebo-Controlled TrialJulie Carillon0Claire Notin1Karine Schmitt2Guy Simoneau3Dominique Lacan4Bionov Company, 939 rue de la Croix Verte, Montpellier 34090, FranceSeppic Company, 22 Terasse Bellini, Puteaux 92806, FranceBionov Company, 939 rue de la Croix Verte, Montpellier 34090, FranceTherapeutic Research Unit, Department of Internal Medicine, Lariboisière Hospital, 2 rue Ambroise-Paré, Paris 75010, FranceBionov Company, 939 rue de la Croix Verte, Montpellier 34090, FranceBackground: We aimed to investigate effects of superoxide dismutase (SOD)-melon concentrate supplementation on psychological stress, physical and mental fatigue in healthy people. Methods: A randomized, double-blind, placebo-controlled trial was performed on 61 people divided in two groups: active supplement (n = 32) and placebo (n = 29) for 12 weeks. Volunteers were given one small hard capsule per day. One capsule contained 10 mg of SOD-melon concentrate (140 U of SOD) and starch for the active supplement and starch only for the placebo. Stress and fatigue were evaluated using four psychometric scales: PSS-14; SF-36; Stroop tests and Prevost scale. Results: The supplementation with SOD-melon concentrate significantly decreased perceived stress, compared to placebo. Moreover, quality of life was improved and physical and mental fatigue were reduced with SOD-melon concentrate supplementation. Conclusion: SOD-melon concentrate supplementation appears to be an effective and natural way to reduce stress and fatigue. Trial registration: trial approved by the ethical committee of Poitiers (France), and the ClinicalTrials.gov Identifier is NCT01767922.http://www.mdpi.com/2072-6643/6/6/2348psychological stressphysical and mental fatigueoxidative stressmelonsuperoxide dismutasepsychometric scales
collection DOAJ
language English
format Article
sources DOAJ
author Julie Carillon
Claire Notin
Karine Schmitt
Guy Simoneau
Dominique Lacan
spellingShingle Julie Carillon
Claire Notin
Karine Schmitt
Guy Simoneau
Dominique Lacan
Dietary Supplementation with a Superoxide Dismutase-Melon Concentrate Reduces Stress, Physical and Mental Fatigue in Healthy People: A Randomised, Double-Blind, Placebo-Controlled Trial
Nutrients
psychological stress
physical and mental fatigue
oxidative stress
melon
superoxide dismutase
psychometric scales
author_facet Julie Carillon
Claire Notin
Karine Schmitt
Guy Simoneau
Dominique Lacan
author_sort Julie Carillon
title Dietary Supplementation with a Superoxide Dismutase-Melon Concentrate Reduces Stress, Physical and Mental Fatigue in Healthy People: A Randomised, Double-Blind, Placebo-Controlled Trial
title_short Dietary Supplementation with a Superoxide Dismutase-Melon Concentrate Reduces Stress, Physical and Mental Fatigue in Healthy People: A Randomised, Double-Blind, Placebo-Controlled Trial
title_full Dietary Supplementation with a Superoxide Dismutase-Melon Concentrate Reduces Stress, Physical and Mental Fatigue in Healthy People: A Randomised, Double-Blind, Placebo-Controlled Trial
title_fullStr Dietary Supplementation with a Superoxide Dismutase-Melon Concentrate Reduces Stress, Physical and Mental Fatigue in Healthy People: A Randomised, Double-Blind, Placebo-Controlled Trial
title_full_unstemmed Dietary Supplementation with a Superoxide Dismutase-Melon Concentrate Reduces Stress, Physical and Mental Fatigue in Healthy People: A Randomised, Double-Blind, Placebo-Controlled Trial
title_sort dietary supplementation with a superoxide dismutase-melon concentrate reduces stress, physical and mental fatigue in healthy people: a randomised, double-blind, placebo-controlled trial
publisher MDPI AG
series Nutrients
issn 2072-6643
publishDate 2014-06-01
description Background: We aimed to investigate effects of superoxide dismutase (SOD)-melon concentrate supplementation on psychological stress, physical and mental fatigue in healthy people. Methods: A randomized, double-blind, placebo-controlled trial was performed on 61 people divided in two groups: active supplement (n = 32) and placebo (n = 29) for 12 weeks. Volunteers were given one small hard capsule per day. One capsule contained 10 mg of SOD-melon concentrate (140 U of SOD) and starch for the active supplement and starch only for the placebo. Stress and fatigue were evaluated using four psychometric scales: PSS-14; SF-36; Stroop tests and Prevost scale. Results: The supplementation with SOD-melon concentrate significantly decreased perceived stress, compared to placebo. Moreover, quality of life was improved and physical and mental fatigue were reduced with SOD-melon concentrate supplementation. Conclusion: SOD-melon concentrate supplementation appears to be an effective and natural way to reduce stress and fatigue. Trial registration: trial approved by the ethical committee of Poitiers (France), and the ClinicalTrials.gov Identifier is NCT01767922.
topic psychological stress
physical and mental fatigue
oxidative stress
melon
superoxide dismutase
psychometric scales
url http://www.mdpi.com/2072-6643/6/6/2348
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