Augmented expression of cardiac ankyrin repeat protein is induced by pemetrexed and a possible marker for the pemetrexed resistance in mesothelioma cells

Augmented expression of cardiac ankyrin repeat protein is induced by pemetrexed and a possible marker for the pemetrexed resistance in mesothelioma cells

Abstract Background Pemetrexed (PEM) is an anti-cancer agent targeting DNA and RNA synthesis, and clinically in use for mesothelioma and non-small cell lung carcinoma. A mechanism of resistance to PEM is associated with elevated activities of several enzymes involved in nucleic acid metabolism. Meth...

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Bibliographic Details
Main Authors: Yiyang Qin, Ikuo Sekine, Mengmeng Fan, Yuichi Takiguchi, Yuji Tada, Masato Shingyoji, Michiko Hanazono, Naoto Yamaguchi, Masatoshi Tagawa
Format: Article
Language:English
Published: BMC 2017-12-01
Series:Cancer Cell International
Subjects:
Mesothelioma
PEM resistance
Cardiac ankyrin repeat protein
Biomarker
Online Access:http://link.springer.com/article/10.1186/s12935-017-0493-8

Internet

http://link.springer.com/article/10.1186/s12935-017-0493-8

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