Protective effects of salep against isoniazid liver toxicity in wistar rats
Introduction: Isoniazid is a drug for treatment of tuberculosis. One of the main side effects of this drug is hepatotoxicity, which is a major cause of treatment interruption in tuberculosis. This study is about the preventive effect of Salep on this side effect of isoniazid. Materials and methods:...
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doaj-ad962e05d6c84e71aa98617dfb14bbcd2020-11-24T20:56:57ZengElsevierJournal of Traditional and Complementary Medicine2225-41102018-01-018123924310.1016/j.jtcme.2017.06.001Protective effects of salep against isoniazid liver toxicity in wistar ratsHossein Kargar Jahromi0Morteza Pourahmad1Hassan Ali Abedi2Mohadeseh karimi3Zahra Kargar Jahromi4Zoonoses Research Center, Jahrom University of Medical Sciences, Jahrom, IranZoonoses Research Center, Jahrom University of Medical Sciences, Jahrom, IranResearch Center for Noncommunicable Diseases, Faculty of Medicine, Jahrom University of Medical Sciences, Jahrom, IranStudent Research Committee, Jahrom University of Medical Sciences, Jahrom, IranZoonoses Research Center, Jahrom University of Medical Sciences, Jahrom, IranIntroduction: Isoniazid is a drug for treatment of tuberculosis. One of the main side effects of this drug is hepatotoxicity, which is a major cause of treatment interruption in tuberculosis. This study is about the preventive effect of Salep on this side effect of isoniazid. Materials and methods: This study is an experimental study in which the preventive effect of salep on isoniazid hepatotoxicity is evaluated. In this study 56 rats were randomly placed in 7 eight members groups including: control group, sham, isoniazid and four isoniazid/salep groups. At the end of the study the laboratory criteria and histological features of liver toxicity were compared in different mentioned groups. Results: Significant lower serum levels of liver enzymes, billirubin, MDA and TOC; and significant higher levels of TAC and total proteins, were revealed in isoniazid/salep group in compare to isoniazid alone group. In addition, histological studies had not showed liver injury in isoniazid/salep group, while there was significant liver injury in isoniazid alone group. Conclusions: Orchid extract (salep), probably because of its antioxidant properties, prevent the destructive effects of isoniazid on the liver.http://www.sciencedirect.com/science/article/pii/S2225411017300639SalepIsoniazidLiverRat |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hossein Kargar Jahromi Morteza Pourahmad Hassan Ali Abedi Mohadeseh karimi Zahra Kargar Jahromi |
spellingShingle |
Hossein Kargar Jahromi Morteza Pourahmad Hassan Ali Abedi Mohadeseh karimi Zahra Kargar Jahromi Protective effects of salep against isoniazid liver toxicity in wistar rats Journal of Traditional and Complementary Medicine Salep Isoniazid Liver Rat |
author_facet |
Hossein Kargar Jahromi Morteza Pourahmad Hassan Ali Abedi Mohadeseh karimi Zahra Kargar Jahromi |
author_sort |
Hossein Kargar Jahromi |
title |
Protective effects of salep against isoniazid liver toxicity in wistar rats |
title_short |
Protective effects of salep against isoniazid liver toxicity in wistar rats |
title_full |
Protective effects of salep against isoniazid liver toxicity in wistar rats |
title_fullStr |
Protective effects of salep against isoniazid liver toxicity in wistar rats |
title_full_unstemmed |
Protective effects of salep against isoniazid liver toxicity in wistar rats |
title_sort |
protective effects of salep against isoniazid liver toxicity in wistar rats |
publisher |
Elsevier |
series |
Journal of Traditional and Complementary Medicine |
issn |
2225-4110 |
publishDate |
2018-01-01 |
description |
Introduction: Isoniazid is a drug for treatment of tuberculosis. One of the main side effects of this drug is hepatotoxicity, which is a major cause of treatment interruption in tuberculosis. This study is about the preventive effect of Salep on this side effect of isoniazid.
Materials and methods: This study is an experimental study in which the preventive effect of salep on isoniazid hepatotoxicity is evaluated. In this study 56 rats were randomly placed in 7 eight members groups including: control group, sham, isoniazid and four isoniazid/salep groups. At the end of the study the laboratory criteria and histological features of liver toxicity were compared in different mentioned groups.
Results: Significant lower serum levels of liver enzymes, billirubin, MDA and TOC; and significant higher levels of TAC and total proteins, were revealed in isoniazid/salep group in compare to isoniazid alone group.
In addition, histological studies had not showed liver injury in isoniazid/salep group, while there was significant liver injury in isoniazid alone group.
Conclusions: Orchid extract (salep), probably because of its antioxidant properties, prevent the destructive effects of isoniazid on the liver. |
topic |
Salep Isoniazid Liver Rat |
url |
http://www.sciencedirect.com/science/article/pii/S2225411017300639 |
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AT hosseinkargarjahromi protectiveeffectsofsalepagainstisoniazidlivertoxicityinwistarrats AT mortezapourahmad protectiveeffectsofsalepagainstisoniazidlivertoxicityinwistarrats AT hassanaliabedi protectiveeffectsofsalepagainstisoniazidlivertoxicityinwistarrats AT mohadesehkarimi protectiveeffectsofsalepagainstisoniazidlivertoxicityinwistarrats AT zahrakargarjahromi protectiveeffectsofsalepagainstisoniazidlivertoxicityinwistarrats |
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