Structural Basis for the Specific Neutralization of Stx2a with a Camelid Single Domain Antibody Fragment

Structural Basis for the Specific Neutralization of Stx2a with a Camelid Single Domain Antibody Fragment

Background: Shiga toxin-producing Escherichia coli (STEC) are a subset of pathogens leading to illnesses such as diarrhea, hemolytic uremic syndrome and even death. The Shiga toxins are the main virulence factors and divided in two groups: Stx1 and Stx2, of which the latter is more frequently associ...

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Bibliographic Details
Main Authors: Robert Alvin Bernedo-Navarro, Ema Romão, Tomomasa Yano, Joar Pinto, Henri De Greve, Yann G.-J. Sterckx, Serge Muyldermans
Format: Article
Language:English
Published: MDPI AG 2018-03-01
Series:Toxins
Subjects:
nanobody
Shiga toxin
Stx2
B domain
neutralization
crystal structure
Online Access:http://www.mdpi.com/2072-6651/10/3/108

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