Expression of <it>Fused in sarcoma</it> mutations in mice recapitulates the neuropathology of FUS proteinopathies and provides insight into disease pathogenesis
<p>Abstract</p> <p>Background</p> <p>Mutations in the gene encoding the RNA-binding protein fused in sarcoma (FUS) can cause familial and sporadic amyotrophic lateral sclerosis (ALS) and rarely frontotemproal dementia (FTD). FUS accumulates in neuronal cytoplasmic inclu...
Main Authors: | , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
BMC
2012-10-01
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Series: | Molecular Neurodegeneration |
Subjects: | |
Online Access: | http://www.molecularneurodegeneration.com/content/7/1/53 |