Comparative Histopathological Changes Between Primary Versus Recurrent Rhinosinusitis with Nasal Polyposis
Background: Chronic rhinosinusitis associated with nasal polypi [CRSwNP] is one of the two major chronic rhinosinusitis phenotypes. The histopathological changes of such condition may differ between primary and chronic types.Aim of the work: To differentiate between primary and chronic rhinosinusiti...
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Egyptian knowledge bank
2021-04-01
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doaj-adb86fbb7d4a488ba7f6fef6a5c79c102021-05-15T15:45:14ZengEgyptian knowledge bankInternational Journal of Medical Arts2636-41742682-37802021-04-01321200120710.21608/ijma.2020.42597.1166121246Comparative Histopathological Changes Between Primary Versus Recurrent Rhinosinusitis with Nasal PolyposisWael Fawzy Ismaiel0Ahmed Abd Alrahman Ibrahim1Sami Abdullah Mohammed2Department of Otorhinolaryngology, Damietta Faculty of Medicine, Al-Azhar University, EgyptDepartment of Otorhinolarygology, Damietta Faculty of Medicine, Al-Azhar University, EgyptDepartment of Pathology, Damietta Faculty of Medicine, Al-Azhar University, EgyptBackground: Chronic rhinosinusitis associated with nasal polypi [CRSwNP] is one of the two major chronic rhinosinusitis phenotypes. The histopathological changes of such condition may differ between primary and chronic types.Aim of the work: To differentiate between primary and chronic rhinosinusitis with polypi through detection of the histopathological changes of nasal mucosa.Patients and Methods: Eighty-five patients with CRSwNP scheduled for functional endoscopic sinus surgery (FESS) were divided into two groups; group (1) 35 patients with primary polyposis, group (2) 50 patients with chronic polyposis. A swab was taken from sinus mucosa during FESS and sent for histopathological investigation.Results: We studied 12 histopathogical findings of spacemen of sinus mucosa and found 7 of them had a significant value in comparison between primary and recurrent CRSwNP. The significant increases in chronic recurrent group (2) than primary group (1) were eosinophilic cell count (p=0.044), eosinophilic cell aggregation (p=0.049), basement membrane thickness (P=0.021), Mucosal ulceration (p=0.002), hyperplastic or papillary change (p=0.029), fibrosis (p=0.002) and fungal element (p=0.003).Conclusion: Histopathological findings of sinus mucosa during FESS operation found to be of great value in differentiating between primary and recurrent CRSwNP, however, further studies on large scale groups were recommended to confirm these results.https://ijma.journals.ekb.eg/article_121246_608869805fcf7393ba97c311d301ba84.pdfrhinosinusitisnasalpolyposiseosinophiliarecurrence |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Wael Fawzy Ismaiel Ahmed Abd Alrahman Ibrahim Sami Abdullah Mohammed |
spellingShingle |
Wael Fawzy Ismaiel Ahmed Abd Alrahman Ibrahim Sami Abdullah Mohammed Comparative Histopathological Changes Between Primary Versus Recurrent Rhinosinusitis with Nasal Polyposis International Journal of Medical Arts rhinosinusitis nasal polyposis eosinophilia recurrence |
author_facet |
Wael Fawzy Ismaiel Ahmed Abd Alrahman Ibrahim Sami Abdullah Mohammed |
author_sort |
Wael Fawzy Ismaiel |
title |
Comparative Histopathological Changes Between Primary Versus Recurrent Rhinosinusitis with Nasal Polyposis |
title_short |
Comparative Histopathological Changes Between Primary Versus Recurrent Rhinosinusitis with Nasal Polyposis |
title_full |
Comparative Histopathological Changes Between Primary Versus Recurrent Rhinosinusitis with Nasal Polyposis |
title_fullStr |
Comparative Histopathological Changes Between Primary Versus Recurrent Rhinosinusitis with Nasal Polyposis |
title_full_unstemmed |
Comparative Histopathological Changes Between Primary Versus Recurrent Rhinosinusitis with Nasal Polyposis |
title_sort |
comparative histopathological changes between primary versus recurrent rhinosinusitis with nasal polyposis |
publisher |
Egyptian knowledge bank |
series |
International Journal of Medical Arts |
issn |
2636-4174 2682-3780 |
publishDate |
2021-04-01 |
description |
Background: Chronic rhinosinusitis associated with nasal polypi [CRSwNP] is one of the two major chronic rhinosinusitis phenotypes. The histopathological changes of such condition may differ between primary and chronic types.Aim of the work: To differentiate between primary and chronic rhinosinusitis with polypi through detection of the histopathological changes of nasal mucosa.Patients and Methods: Eighty-five patients with CRSwNP scheduled for functional endoscopic sinus surgery (FESS) were divided into two groups; group (1) 35 patients with primary polyposis, group (2) 50 patients with chronic polyposis. A swab was taken from sinus mucosa during FESS and sent for histopathological investigation.Results: We studied 12 histopathogical findings of spacemen of sinus mucosa and found 7 of them had a significant value in comparison between primary and recurrent CRSwNP. The significant increases in chronic recurrent group (2) than primary group (1) were eosinophilic cell count (p=0.044), eosinophilic cell aggregation (p=0.049), basement membrane thickness (P=0.021), Mucosal ulceration (p=0.002), hyperplastic or papillary change (p=0.029), fibrosis (p=0.002) and fungal element (p=0.003).Conclusion: Histopathological findings of sinus mucosa during FESS operation found to be of great value in differentiating between primary and recurrent CRSwNP, however, further studies on large scale groups were recommended to confirm these results. |
topic |
rhinosinusitis nasal polyposis eosinophilia recurrence |
url |
https://ijma.journals.ekb.eg/article_121246_608869805fcf7393ba97c311d301ba84.pdf |
work_keys_str_mv |
AT waelfawzyismaiel comparativehistopathologicalchangesbetweenprimaryversusrecurrentrhinosinusitiswithnasalpolyposis AT ahmedabdalrahmanibrahim comparativehistopathologicalchangesbetweenprimaryversusrecurrentrhinosinusitiswithnasalpolyposis AT samiabdullahmohammed comparativehistopathologicalchangesbetweenprimaryversusrecurrentrhinosinusitiswithnasalpolyposis |
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1721440629829926912 |