HIV alters neuronal mitochondrial fission/fusion in the brain during HIV-associated neurocognitive disorders

HIV alters neuronal mitochondrial fission/fusion in the brain during HIV-associated neurocognitive disorders

HIV-associated neurocognitive disorders (HAND) still occur in approximately 50% of HIV patients, and therapies to combat HAND progression are urgently needed. HIV proteins are released from infected cells and cause neuronal damage, possibly through mitochondrial abnormalities. Altered mitochondrial...

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Bibliographic Details
Main Authors: Jerel Adam Fields, Elisabeth Serger, Sofia Campos, Ajit S. Divakaruni, Changyoun Kim, Kendall Smith, Margarita Trejo, Anthony Adame, Brian Spencer, Edward Rockenstein, Anne N. Murphy, Ronald J. Ellis, Scott Letendre, Igor Grant, Eliezer Masliah
Format: Article
Language:English
Published: Elsevier 2016-02-01
Series:Neurobiology of Disease
Subjects:
HIV
Mitochondria
Fission/fusion
DNM1L
gp120
Neurodegeneration
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996115300954

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