The Role of Kv7.2 in Neurodevelopment: Insights and Gaps in Our Understanding

The Role of Kv7.2 in Neurodevelopment: Insights and Gaps in Our Understanding

Kv7.2 subunits encoded by the KCNQ2 gene constitute a critical molecular component of the M-current, a subthreshold voltage-gated potassium current controlling neuronal excitability by dampening repetitive action potential firing. Pathogenic loss-of-function variants in KCNQ2 have been linked to epi...

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Bibliographic Details
Main Authors: Nina Dirkx, Francesco Miceli, Maurizio Taglialatela, Sarah Weckhuysen
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Physiology
Subjects:
KCNQ2
M-current
neurodevelopment
KCNQ2-encephalopathy
Kv7.2
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2020.570588/full

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