Exosomal DLX6-AS1 from hepatocellular carcinoma cells induces M2 macrophage polarization to promote migration and invasion in hepatocellular carcinoma through microRNA-15a-5p/CXCL17 axis

Exosomal DLX6-AS1 from hepatocellular carcinoma cells induces M2 macrophage polarization to promote migration and invasion in hepatocellular carcinoma through microRNA-15a-5p/CXCL17 axis

Abstract Background Hepatocellular carcinoma (HCC) cells-secreted exosomes (exo) could stimulate M2 macrophage polarization and promote HCC progression, but the related mechanism of long non-coding RNA distal-less homeobox 6 antisense 1 (DLX6-AS1) with HCC-exo-mediated M2 macrophage polarization is...

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Bibliographic Details
Main Authors: Lin-pei Wang, Jing Lin, Xiao-qiu Ma, Dong-yao Xu, Chun-feng Shi, Wei Wang, Xiao-jie Jiang
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Hepatocellular carcinoma
Hepatocellular carcinoma cell-secreted exosomes
M2 macrophages
Long non-coding RNA distal-less homeobox 6 antisense 1
microRNA-15a-5p
C-X-C motif chemokine ligand 17
Online Access:https://doi.org/10.1186/s13046-021-01973-z

Internet

https://doi.org/10.1186/s13046-021-01973-z

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