Effect of Adding Oral Calcium Dobesilate to Laser Photocoagulation on the Macular Thickness in Patients with Diabetic Macular Edema: A Randomized Clinical Trial
Purpose: To evaluate the effect of oral calcium dobesilate (Doxium) on macular thickness in clinically significant macular edema (CSME). Methods: Overall, 71 eyes of 40 patients with non-proliferative diabetic retinopathy and clinically significant macular edema were included. All patients were rec...
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Tabriz University of Medical Sciences
2014-12-01
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doaj-adc8fca29c4e463c9555a6df1d59175c2020-11-24T23:22:55ZengTabriz University of Medical Sciences Advanced Pharmaceutical Bulletin2228-58812251-73082014-12-014437537810.5681/apb.2014.055Effect of Adding Oral Calcium Dobesilate to Laser Photocoagulation on the Macular Thickness in Patients with Diabetic Macular Edema: A Randomized Clinical TrialMostafa Feghhi0Fereydoun Farrahi1Mohammadreza Abbaspour2Akbar Takhtaeian3Infectious Ophthalmic Research Center, Department of Ophthalmology, Imam Khomeini Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.Infectious Ophthalmic Research Center, Department of Ophthalmology, Imam Khomeini Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.Nanotechnology Research Center, Department of Pharmaceutics, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.Infectious Ophthalmic Research Center, Department of Ophthalmology, Imam Khomeini Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.Purpose: To evaluate the effect of oral calcium dobesilate (Doxium) on macular thickness in clinically significant macular edema (CSME). Methods: Overall, 71 eyes of 40 patients with non-proliferative diabetic retinopathy and clinically significant macular edema were included. All patients were received laser treatment for macular edema. Coherence optical tomography was used to determine the retinal thickness. Patients were randomized into two groups: group A received three Doxium capsule daily and group B received three placebo capsule daily for six months. Results: The mean macular thickness before and after treatment in the group A was 340 and 257 micrometers respectively (24.5% reduced), and in the group B was 336 micrometers and 263 micrometers respectively (21.5% reduced). Macular thickness significantly decreased after treatment in both groups and the reduction in group A is higher but the difference of reduction between the two groups was not statistically significant (P>0.05). Conclusion: In respect to the effect of adding oral Doxium to Laser Photocoagulation on the macular thickness in patients with diabetic macular edema, this study showed no statistically significant difference between Doxium and placebo.http://journals.tbzmed.ac.ir/APB/Manuscript/APB-4-375.pdfCalcium dobesilate (Doxium)Clinically significant macular edema (CSME)Macular thicknessDiabetic retinopathyMacular photocoagulation (MPC) |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mostafa Feghhi Fereydoun Farrahi Mohammadreza Abbaspour Akbar Takhtaeian |
spellingShingle |
Mostafa Feghhi Fereydoun Farrahi Mohammadreza Abbaspour Akbar Takhtaeian Effect of Adding Oral Calcium Dobesilate to Laser Photocoagulation on the Macular Thickness in Patients with Diabetic Macular Edema: A Randomized Clinical Trial Advanced Pharmaceutical Bulletin Calcium dobesilate (Doxium) Clinically significant macular edema (CSME) Macular thickness Diabetic retinopathy Macular photocoagulation (MPC) |
author_facet |
Mostafa Feghhi Fereydoun Farrahi Mohammadreza Abbaspour Akbar Takhtaeian |
author_sort |
Mostafa Feghhi |
title |
Effect of Adding Oral Calcium Dobesilate to Laser Photocoagulation on the Macular Thickness in Patients with Diabetic Macular Edema: A Randomized Clinical Trial |
title_short |
Effect of Adding Oral Calcium Dobesilate to Laser Photocoagulation on the Macular Thickness in Patients with Diabetic Macular Edema: A Randomized Clinical Trial |
title_full |
Effect of Adding Oral Calcium Dobesilate to Laser Photocoagulation on the Macular Thickness in Patients with Diabetic Macular Edema: A Randomized Clinical Trial |
title_fullStr |
Effect of Adding Oral Calcium Dobesilate to Laser Photocoagulation on the Macular Thickness in Patients with Diabetic Macular Edema: A Randomized Clinical Trial |
title_full_unstemmed |
Effect of Adding Oral Calcium Dobesilate to Laser Photocoagulation on the Macular Thickness in Patients with Diabetic Macular Edema: A Randomized Clinical Trial |
title_sort |
effect of adding oral calcium dobesilate to laser photocoagulation on the macular thickness in patients with diabetic macular edema: a randomized clinical trial |
publisher |
Tabriz University of Medical Sciences |
series |
Advanced Pharmaceutical Bulletin |
issn |
2228-5881 2251-7308 |
publishDate |
2014-12-01 |
description |
Purpose: To evaluate the effect of oral calcium dobesilate (Doxium) on macular thickness in clinically significant macular edema (CSME).
Methods: Overall, 71 eyes of 40 patients with non-proliferative diabetic retinopathy and clinically significant macular edema were included. All patients were received laser treatment for macular edema. Coherence optical tomography was used to determine the retinal thickness. Patients were randomized into two groups: group A received three Doxium capsule daily and group B received three placebo capsule daily for six months.
Results: The mean macular thickness before and after treatment in the group A was 340 and 257 micrometers respectively (24.5% reduced), and in the group B was 336 micrometers and 263 micrometers respectively (21.5% reduced). Macular thickness significantly decreased after treatment in both groups and the reduction in group A is higher but the difference of reduction between the two groups was not statistically significant (P>0.05).
Conclusion: In respect to the effect of adding oral Doxium to Laser Photocoagulation on the macular thickness in patients with diabetic macular edema, this study showed no statistically significant difference between Doxium and placebo. |
topic |
Calcium dobesilate (Doxium) Clinically significant macular edema (CSME) Macular thickness Diabetic retinopathy Macular photocoagulation (MPC) |
url |
http://journals.tbzmed.ac.ir/APB/Manuscript/APB-4-375.pdf |
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