Cardioprotective effect of grape polyphenol extract against doxorubicin induced cardiotoxicity
Abstract Doxorubicin is a chemotherapeutic agent known to cause cardiotoxicity that is thought to be associated with oxidative stress. The aim of the current study is to investigate the role of grape polyphenols’ antioxidant property as cardioprotective against doxorubicin-induced cardiotoxicity. Ad...
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2020-09-01
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doaj-addb75b23a534e15b589a362043d8cef2021-09-12T11:19:14ZengNature Publishing GroupScientific Reports2045-23222020-09-0110111210.1038/s41598-020-71827-9Cardioprotective effect of grape polyphenol extract against doxorubicin induced cardiotoxicityShynggys Sergazy0Zarina Shulgau1Galina Fedotovskikh2Laura Chulenbayeva3Ayaulym Nurgozhina4Madiyar Nurgaziyev5Elena Krivyh6Yevgeny Kamyshanskiy7Almagul Kushugulova8Alexander Gulyayev9Mohamad Aljofan10Private Institution “National Laboratory Astana”, AOE “Nazarbayaev University”RSE “National Center for Biotechnology”, Ministry of Education and Science of Republic of KazakhstanJSC “National Scientific Medical Center”Private Institution “National Laboratory Astana”, AOE “Nazarbayaev University”Private Institution “National Laboratory Astana”, AOE “Nazarbayaev University”Private Institution “National Laboratory Astana”, AOE “Nazarbayaev University”Khanty-Mansiysk State Medical AcademyKaraganda State Medical UniversityPrivate Institution “National Laboratory Astana”, AOE “Nazarbayaev University”Private Institution “National Laboratory Astana”, AOE “Nazarbayaev University”Department of Biomedical Sciences, School of Medicine, AOE “Nazarbayaev University”Abstract Doxorubicin is a chemotherapeutic agent known to cause cardiotoxicity that is thought to be associated with oxidative stress. The aim of the current study is to investigate the role of grape polyphenols’ antioxidant property as cardioprotective against doxorubicin-induced cardiotoxicity. Adult Wistar rats weighing 200 ± 20 g were divided into 3 different groups: a doxorubicin group that received a single intraperitoneal administration of doxorubicin (8.0 mg/kg body weight), an experimental group that received doxorubicin and grape polyphenol concentrate (25 mg/kg) via intragastric route, and the third group was a negative control group that received water only. On day 8, blood samples and tissues were harvested for analyses. The results indicated that grape polyphenol concentrate was able to reduce the signs of cardiotoxicity of doxorubicin through the reduction of aspartate aminotransferase activation, increasing the plasma antioxidant levels and decreasing the level of free radicals. The results also showed that grape polyphenol concentrate was able to reverse doxorubicin-induced microscopic myocardial damage. The myocardial protective effect of grape polyphenol might likely be due to the increase in the level and activity of the antioxidant enzymes, superoxide dismutase, catalase, and glutathione peroxidase. In conclusion, grape polyphenol concentrate displayed cardioprotective effect and was able to reverse doxorubicin-induced-cardiomyopathy in experimental rats.https://doi.org/10.1038/s41598-020-71827-9 |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Shynggys Sergazy Zarina Shulgau Galina Fedotovskikh Laura Chulenbayeva Ayaulym Nurgozhina Madiyar Nurgaziyev Elena Krivyh Yevgeny Kamyshanskiy Almagul Kushugulova Alexander Gulyayev Mohamad Aljofan |
spellingShingle |
Shynggys Sergazy Zarina Shulgau Galina Fedotovskikh Laura Chulenbayeva Ayaulym Nurgozhina Madiyar Nurgaziyev Elena Krivyh Yevgeny Kamyshanskiy Almagul Kushugulova Alexander Gulyayev Mohamad Aljofan Cardioprotective effect of grape polyphenol extract against doxorubicin induced cardiotoxicity Scientific Reports |
author_facet |
Shynggys Sergazy Zarina Shulgau Galina Fedotovskikh Laura Chulenbayeva Ayaulym Nurgozhina Madiyar Nurgaziyev Elena Krivyh Yevgeny Kamyshanskiy Almagul Kushugulova Alexander Gulyayev Mohamad Aljofan |
author_sort |
Shynggys Sergazy |
title |
Cardioprotective effect of grape polyphenol extract against doxorubicin induced cardiotoxicity |
title_short |
Cardioprotective effect of grape polyphenol extract against doxorubicin induced cardiotoxicity |
title_full |
Cardioprotective effect of grape polyphenol extract against doxorubicin induced cardiotoxicity |
title_fullStr |
Cardioprotective effect of grape polyphenol extract against doxorubicin induced cardiotoxicity |
title_full_unstemmed |
Cardioprotective effect of grape polyphenol extract against doxorubicin induced cardiotoxicity |
title_sort |
cardioprotective effect of grape polyphenol extract against doxorubicin induced cardiotoxicity |
publisher |
Nature Publishing Group |
series |
Scientific Reports |
issn |
2045-2322 |
publishDate |
2020-09-01 |
description |
Abstract Doxorubicin is a chemotherapeutic agent known to cause cardiotoxicity that is thought to be associated with oxidative stress. The aim of the current study is to investigate the role of grape polyphenols’ antioxidant property as cardioprotective against doxorubicin-induced cardiotoxicity. Adult Wistar rats weighing 200 ± 20 g were divided into 3 different groups: a doxorubicin group that received a single intraperitoneal administration of doxorubicin (8.0 mg/kg body weight), an experimental group that received doxorubicin and grape polyphenol concentrate (25 mg/kg) via intragastric route, and the third group was a negative control group that received water only. On day 8, blood samples and tissues were harvested for analyses. The results indicated that grape polyphenol concentrate was able to reduce the signs of cardiotoxicity of doxorubicin through the reduction of aspartate aminotransferase activation, increasing the plasma antioxidant levels and decreasing the level of free radicals. The results also showed that grape polyphenol concentrate was able to reverse doxorubicin-induced microscopic myocardial damage. The myocardial protective effect of grape polyphenol might likely be due to the increase in the level and activity of the antioxidant enzymes, superoxide dismutase, catalase, and glutathione peroxidase. In conclusion, grape polyphenol concentrate displayed cardioprotective effect and was able to reverse doxorubicin-induced-cardiomyopathy in experimental rats. |
url |
https://doi.org/10.1038/s41598-020-71827-9 |
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