Prognostic value of EGFR and KRAS in resected non-small cell lung cancer: a systematic review and meta-analysis
Shi-Ming Zhang, Qing-Ge Zhu, Xiao-Xiao Ding, Song Lin, Jing Zhao, Lei Guan, Ting Li, Bing He, Hu-Qin Zhang The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi’an JiaoTong University, Xi’an, 710049, China Bac...
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doaj-ade717050b8441b2826b6f8e02240c3a2020-11-25T00:46:35ZengDove Medical PressCancer Management and Research1179-13222018-09-01Volume 103393340440452Prognostic value of EGFR and KRAS in resected non-small cell lung cancer: a systematic review and meta-analysisZhang SMZhu QGDing XXLin SZhao JGuan LLi THe BZhang HQShi-Ming Zhang, Qing-Ge Zhu, Xiao-Xiao Ding, Song Lin, Jing Zhao, Lei Guan, Ting Li, Bing He, Hu-Qin Zhang The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi’an JiaoTong University, Xi’an, 710049, China Background: The prognostic value of EGFR and KRAS mutations in resected non-small cell lung cancer (NSCLC) has been reported. However, conflicting results were reported in these studies. The effect of mutations in these two genes in resected NSCLC remains controversial.Methods: We searched Internet databases for studies reporting disease-free survival (DFS) and overall survival (OS) in resected NSCLC patients with EGFR or KRAS mutations. A meta-analysis calculating the pooled hazard ratio (HR) for DFS and OS was used to measure the association of EGFR or KRAS mutations with the prognosis of patients after surgery.Results: A total of 9,635 patients from 32 studies were included in this analysis. The combined HR for EGFR mutations on DFS was 0.77 (95% CI 0.66–0.90, p=0.001) and on OS was 0.72 (95% CI 0.66–0.80, p<0.00001). In addition, the combined HR for KRAS mutations on DFS was 1.5 (95% CI 1.15–1.96, p=0.002) and on OS was 1.49 (95% CI 1.28–1.73, p<0.00001). Sensitivity analysis, subgroup analysis, and bias analysis proved the stability of the results.Conclusion: The analysis showed that EGFR mutations were significantly associated with DFS and OS. These findings indicated that surgically treated NSCLC patients with EGFR mutations were inclined to exhibit a prolonged DFS and OS. In addition, the results indicated that KRAS mutations predicted worse DFS and OS in patients with resected NSCLC. Keywords: EGFR mutations, KRAS mutations, meta-analysis, non-small cell lung cancer, prognosis, resectedhttps://www.dovepress.com/prognostic-value-of-egfr-and-kras-in-resected-non-small-cell-lung-canc-peer-reviewed-article-CMAREGFR mutationsKRAS mutationsmeta-analysisnon-small cell lung cancerprognosisresected |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Zhang SM Zhu QG Ding XX Lin S Zhao J Guan L Li T He B Zhang HQ |
spellingShingle |
Zhang SM Zhu QG Ding XX Lin S Zhao J Guan L Li T He B Zhang HQ Prognostic value of EGFR and KRAS in resected non-small cell lung cancer: a systematic review and meta-analysis Cancer Management and Research EGFR mutations KRAS mutations meta-analysis non-small cell lung cancer prognosis resected |
author_facet |
Zhang SM Zhu QG Ding XX Lin S Zhao J Guan L Li T He B Zhang HQ |
author_sort |
Zhang SM |
title |
Prognostic value of EGFR and KRAS in resected non-small cell lung cancer: a systematic review and meta-analysis |
title_short |
Prognostic value of EGFR and KRAS in resected non-small cell lung cancer: a systematic review and meta-analysis |
title_full |
Prognostic value of EGFR and KRAS in resected non-small cell lung cancer: a systematic review and meta-analysis |
title_fullStr |
Prognostic value of EGFR and KRAS in resected non-small cell lung cancer: a systematic review and meta-analysis |
title_full_unstemmed |
Prognostic value of EGFR and KRAS in resected non-small cell lung cancer: a systematic review and meta-analysis |
title_sort |
prognostic value of egfr and kras in resected non-small cell lung cancer: a systematic review and meta-analysis |
publisher |
Dove Medical Press |
series |
Cancer Management and Research |
issn |
1179-1322 |
publishDate |
2018-09-01 |
description |
Shi-Ming Zhang, Qing-Ge Zhu, Xiao-Xiao Ding, Song Lin, Jing Zhao, Lei Guan, Ting Li, Bing He, Hu-Qin Zhang The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi’an JiaoTong University, Xi’an, 710049, China Background: The prognostic value of EGFR and KRAS mutations in resected non-small cell lung cancer (NSCLC) has been reported. However, conflicting results were reported in these studies. The effect of mutations in these two genes in resected NSCLC remains controversial.Methods: We searched Internet databases for studies reporting disease-free survival (DFS) and overall survival (OS) in resected NSCLC patients with EGFR or KRAS mutations. A meta-analysis calculating the pooled hazard ratio (HR) for DFS and OS was used to measure the association of EGFR or KRAS mutations with the prognosis of patients after surgery.Results: A total of 9,635 patients from 32 studies were included in this analysis. The combined HR for EGFR mutations on DFS was 0.77 (95% CI 0.66–0.90, p=0.001) and on OS was 0.72 (95% CI 0.66–0.80, p<0.00001). In addition, the combined HR for KRAS mutations on DFS was 1.5 (95% CI 1.15–1.96, p=0.002) and on OS was 1.49 (95% CI 1.28–1.73, p<0.00001). Sensitivity analysis, subgroup analysis, and bias analysis proved the stability of the results.Conclusion: The analysis showed that EGFR mutations were significantly associated with DFS and OS. These findings indicated that surgically treated NSCLC patients with EGFR mutations were inclined to exhibit a prolonged DFS and OS. In addition, the results indicated that KRAS mutations predicted worse DFS and OS in patients with resected NSCLC. Keywords: EGFR mutations, KRAS mutations, meta-analysis, non-small cell lung cancer, prognosis, resected |
topic |
EGFR mutations KRAS mutations meta-analysis non-small cell lung cancer prognosis resected |
url |
https://www.dovepress.com/prognostic-value-of-egfr-and-kras-in-resected-non-small-cell-lung-canc-peer-reviewed-article-CMAR |
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