Non-viral gene delivery systems for tissue repair and regeneration
Abstract Critical tissue defects frequently result from trauma, burns, chronic wounds and/or surgery. The ideal treatment for such tissue loss is autografting, but donor sites are often limited. Tissue engineering (TE) is an inspiring alternative for tissue repair and regeneration (TRR). One of the...
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doaj-adff6b1bd1894592894ec71220c6da912020-11-24T21:33:18ZengBMCJournal of Translational Medicine1479-58762018-02-0116112010.1186/s12967-018-1402-1Non-viral gene delivery systems for tissue repair and regenerationPan Wu0Haojiao Chen1Ronghua Jin2Tingting Weng3Jon Kee Ho4Chuangang You5Liping Zhang6Xingang Wang7Chunmao Han8Department of Burns & Wound Care Center, Second Affiliated Hospital of Medical College, Zhejiang UniversityDepartment of Burns & Wound Care Center, Second Affiliated Hospital of Medical College, Zhejiang UniversityDepartment of Burns & Wound Care Center, Second Affiliated Hospital of Medical College, Zhejiang UniversityDepartment of Burns & Wound Care Center, Second Affiliated Hospital of Medical College, Zhejiang UniversityDepartment of Burns & Wound Care Center, Second Affiliated Hospital of Medical College, Zhejiang UniversityDepartment of Burns & Wound Care Center, Second Affiliated Hospital of Medical College, Zhejiang UniversityDepartment of Burns & Wound Care Center, Second Affiliated Hospital of Medical College, Zhejiang UniversityDepartment of Burns & Wound Care Center, Second Affiliated Hospital of Medical College, Zhejiang UniversityDepartment of Burns & Wound Care Center, Second Affiliated Hospital of Medical College, Zhejiang UniversityAbstract Critical tissue defects frequently result from trauma, burns, chronic wounds and/or surgery. The ideal treatment for such tissue loss is autografting, but donor sites are often limited. Tissue engineering (TE) is an inspiring alternative for tissue repair and regeneration (TRR). One of the current state-of-the-art methods for TRR is gene therapy. Non-viral gene delivery systems (nVGDS) have great potential for TE and have several advantages over viral delivery including lower immunogenicity and toxicity, better cell specificity, better modifiability, and higher productivity. However, there is no ideal nVGDS for TRR, hence, there is widespread research to improve their properties. This review introduces the basic principles and key aspects of commonly-used nVGDSs. We focus on recent advances in their applications, current challenges, and future directions.http://link.springer.com/article/10.1186/s12967-018-1402-1Non-viral vectorTissue engineeringGene therapy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Pan Wu Haojiao Chen Ronghua Jin Tingting Weng Jon Kee Ho Chuangang You Liping Zhang Xingang Wang Chunmao Han |
spellingShingle |
Pan Wu Haojiao Chen Ronghua Jin Tingting Weng Jon Kee Ho Chuangang You Liping Zhang Xingang Wang Chunmao Han Non-viral gene delivery systems for tissue repair and regeneration Journal of Translational Medicine Non-viral vector Tissue engineering Gene therapy |
author_facet |
Pan Wu Haojiao Chen Ronghua Jin Tingting Weng Jon Kee Ho Chuangang You Liping Zhang Xingang Wang Chunmao Han |
author_sort |
Pan Wu |
title |
Non-viral gene delivery systems for tissue repair and regeneration |
title_short |
Non-viral gene delivery systems for tissue repair and regeneration |
title_full |
Non-viral gene delivery systems for tissue repair and regeneration |
title_fullStr |
Non-viral gene delivery systems for tissue repair and regeneration |
title_full_unstemmed |
Non-viral gene delivery systems for tissue repair and regeneration |
title_sort |
non-viral gene delivery systems for tissue repair and regeneration |
publisher |
BMC |
series |
Journal of Translational Medicine |
issn |
1479-5876 |
publishDate |
2018-02-01 |
description |
Abstract Critical tissue defects frequently result from trauma, burns, chronic wounds and/or surgery. The ideal treatment for such tissue loss is autografting, but donor sites are often limited. Tissue engineering (TE) is an inspiring alternative for tissue repair and regeneration (TRR). One of the current state-of-the-art methods for TRR is gene therapy. Non-viral gene delivery systems (nVGDS) have great potential for TE and have several advantages over viral delivery including lower immunogenicity and toxicity, better cell specificity, better modifiability, and higher productivity. However, there is no ideal nVGDS for TRR, hence, there is widespread research to improve their properties. This review introduces the basic principles and key aspects of commonly-used nVGDSs. We focus on recent advances in their applications, current challenges, and future directions. |
topic |
Non-viral vector Tissue engineering Gene therapy |
url |
http://link.springer.com/article/10.1186/s12967-018-1402-1 |
work_keys_str_mv |
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