Effect of Consumption of Tribulus Terrestris on Serum Glucose and Lipid Levels in Diabetic Rats
Introduction: The effect of Tribulus terrestris (TT) on serum glucose and lipid levels was investigated in an experimental model of diabetes mellitus in rats. Methods: Female Wistar rats were divided into control, TT-treated control, diabetic, glibenclamide-treated, and TT-treated diabetic groups. F...
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Shahid Sadoughi University of Medical Sciences
2010-03-01
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doaj-ae04f3123c85469cac4989c9414009972020-11-25T01:24:55ZfasShahid Sadoughi University of Medical SciencesMajallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd2228-57412228-57332010-03-011811723Effect of Consumption of Tribulus Terrestris on Serum Glucose and Lipid Levels in Diabetic RatsM RoghaniT Baluchnejad MojarradN AndalibiF AnsariM SharayeliIntroduction: The effect of Tribulus terrestris (TT) on serum glucose and lipid levels was investigated in an experimental model of diabetes mellitus in rats. Methods: Female Wistar rats were divided into control, TT-treated control, diabetic, glibenclamide-treated, and TT-treated diabetic groups. For induction of diabetes, streptozotcin (STZ) was administered (60 mg/Kg). Meanwhile, TT-treated groups received TT mixed with standard pelleted food at a weight ratio of 6.25% for 6 weeks. Serum glucose and lipid levels were determined before the study and at the 3rd and 4th week after the study. Results: Serum glucose was significantly lower in TT-treated diabetic rats at 3rd and 6th weeks as compared to untreated diabetics (p<0.01 and p<0.005, respectively). In addition, serum total cholesterol, triglyceride, and LDL-cholesterol showed a significant reduction in TT-treated diabetic rats as compared to untreated diabetics (p<0.05). On the other hand, HDL-cholesterol level did not change significantly in TT-treated diabetic group as compared to untreated diabetic group. Conclusions: Oral administration of TT has a significant hypoglycemic effect and in long term leads to appropriate changes in serum LDL-cholesterol, total cholesterol, and triglyceride levels, but does not affect HDL-cholesterol levels in diabetic rats.http://85.185.157.11:6280/jssu/browse.php?a_id=1005&slc_lang=en&sid=1&ftxt=1Tribulus TerrestrisDiabetes MellitusGlucoseLipids |
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DOAJ |
language |
fas |
format |
Article |
sources |
DOAJ |
author |
M Roghani T Baluchnejad Mojarrad N Andalibi F Ansari M Sharayeli |
spellingShingle |
M Roghani T Baluchnejad Mojarrad N Andalibi F Ansari M Sharayeli Effect of Consumption of Tribulus Terrestris on Serum Glucose and Lipid Levels in Diabetic Rats Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd Tribulus Terrestris Diabetes Mellitus Glucose Lipids |
author_facet |
M Roghani T Baluchnejad Mojarrad N Andalibi F Ansari M Sharayeli |
author_sort |
M Roghani |
title |
Effect of Consumption of Tribulus Terrestris on Serum Glucose and Lipid Levels in Diabetic Rats |
title_short |
Effect of Consumption of Tribulus Terrestris on Serum Glucose and Lipid Levels in Diabetic Rats |
title_full |
Effect of Consumption of Tribulus Terrestris on Serum Glucose and Lipid Levels in Diabetic Rats |
title_fullStr |
Effect of Consumption of Tribulus Terrestris on Serum Glucose and Lipid Levels in Diabetic Rats |
title_full_unstemmed |
Effect of Consumption of Tribulus Terrestris on Serum Glucose and Lipid Levels in Diabetic Rats |
title_sort |
effect of consumption of tribulus terrestris on serum glucose and lipid levels in diabetic rats |
publisher |
Shahid Sadoughi University of Medical Sciences |
series |
Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd |
issn |
2228-5741 2228-5733 |
publishDate |
2010-03-01 |
description |
Introduction: The effect of Tribulus terrestris (TT) on serum glucose and lipid levels was investigated in an experimental model of diabetes mellitus in rats. Methods: Female Wistar rats were divided into control, TT-treated control, diabetic, glibenclamide-treated, and TT-treated diabetic groups. For induction of diabetes, streptozotcin (STZ) was administered (60 mg/Kg). Meanwhile, TT-treated groups received TT mixed with standard pelleted food at a weight ratio of 6.25% for 6 weeks. Serum glucose and lipid levels were determined before the study and at the 3rd and 4th week after the study. Results: Serum glucose was significantly lower in TT-treated diabetic rats at 3rd and 6th weeks as compared to untreated diabetics (p<0.01 and p<0.005, respectively). In addition, serum total cholesterol, triglyceride, and LDL-cholesterol showed a significant reduction in TT-treated diabetic rats as compared to untreated diabetics (p<0.05). On the other hand, HDL-cholesterol level did not change significantly in TT-treated diabetic group as compared to untreated diabetic group. Conclusions: Oral administration of TT has a significant hypoglycemic effect and in long term leads to appropriate changes in serum LDL-cholesterol, total cholesterol, and triglyceride levels, but does not affect HDL-cholesterol levels in diabetic rats. |
topic |
Tribulus Terrestris Diabetes Mellitus Glucose Lipids |
url |
http://85.185.157.11:6280/jssu/browse.php?a_id=1005&slc_lang=en&sid=1&ftxt=1 |
work_keys_str_mv |
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