A 200-year history of Parkinson's disease
<p>In 1817, Dr. James Parkinson firstly described the concept, duration, and clinical characteristics of Parkinson's disease (PD). However, it was widely known until 1877 when it was named "Parkinson's disease" by Dr. Jean-Martin Charcot. In 1912, Frederic Henry Lewy, a...
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doaj-ae0a646aa5ac4cfdb65f86b333e2b1cb2020-11-24T23:07:47ZengTianjin Huanhu HospitalChinese Journal of Contemporary Neurology and Neurosurgery1672-67312017-01-01171581497A 200-year history of Parkinson's diseaseXiao-dan WANG0Yong JI1Department of Neurology, Tianjin Huanhu Hospital, Tianjin 300350, ChinaDepartment of Neurology, Tianjin Huanhu Hospital, Tianjin 300350, China<p>In 1817, Dr. James Parkinson firstly described the concept, duration, and clinical characteristics of Parkinson's disease (PD). However, it was widely known until 1877 when it was named "Parkinson's disease" by Dr. Jean-Martin Charcot. In 1912, Frederic Henry Lewy, a neuropathologist, found a special abnormal protein in nerve cells of PD patients. Medical profession began to learn about the pathology of PD only when Konstantin Tretiakoff named the special abnormal protein "Lewy body (LB)" in 1919 and believed the main lesion of PD was in substantia nigra. In 1867, the German psychiatrist Leopold Ordenstein found that PD patients had symptoms of excitement of parasympathetic nerve, such as salivation, and treated them with belladonna alkaloids, thus creating a precedent for medical treatment of PD. After 1950's, the researchers gradually found that Lewy body was common in substantia nigra and locus coeruleus of PD patients and then gradually determined the pathological features of PD. The Swedish scientist Arvid Carlsson and Japanese neurologist Isamu Sano found dopamine abnormalities in the brain of PD patients, and thus researched and developed levodopa. PD has a history of 200 years, and we expect new research of PD studies.</p><p> </p><p><strong>DOI: </strong>10.3969/j.issn.1672-6731.2017.01.002</p>http://www.cjcnn.org/index.php/cjcnn/article/view/1528Parkinson diseaseHistory of medicineReview |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xiao-dan WANG Yong JI |
spellingShingle |
Xiao-dan WANG Yong JI A 200-year history of Parkinson's disease Chinese Journal of Contemporary Neurology and Neurosurgery Parkinson disease History of medicine Review |
author_facet |
Xiao-dan WANG Yong JI |
author_sort |
Xiao-dan WANG |
title |
A 200-year history of Parkinson's disease |
title_short |
A 200-year history of Parkinson's disease |
title_full |
A 200-year history of Parkinson's disease |
title_fullStr |
A 200-year history of Parkinson's disease |
title_full_unstemmed |
A 200-year history of Parkinson's disease |
title_sort |
200-year history of parkinson's disease |
publisher |
Tianjin Huanhu Hospital |
series |
Chinese Journal of Contemporary Neurology and Neurosurgery |
issn |
1672-6731 |
publishDate |
2017-01-01 |
description |
<p>In 1817, Dr. James Parkinson firstly described the concept, duration, and clinical characteristics of Parkinson's disease (PD). However, it was widely known until 1877 when it was named "Parkinson's disease" by Dr. Jean-Martin Charcot. In 1912, Frederic Henry Lewy, a neuropathologist, found a special abnormal protein in nerve cells of PD patients. Medical profession began to learn about the pathology of PD only when Konstantin Tretiakoff named the special abnormal protein "Lewy body (LB)" in 1919 and believed the main lesion of PD was in substantia nigra. In 1867, the German psychiatrist Leopold Ordenstein found that PD patients had symptoms of excitement of parasympathetic nerve, such as salivation, and treated them with belladonna alkaloids, thus creating a precedent for medical treatment of PD. After 1950's, the researchers gradually found that Lewy body was common in substantia nigra and locus coeruleus of PD patients and then gradually determined the pathological features of PD. The Swedish scientist Arvid Carlsson and Japanese neurologist Isamu Sano found dopamine abnormalities in the brain of PD patients, and thus researched and developed levodopa. PD has a history of 200 years, and we expect new research of PD studies.</p><p> </p><p><strong>DOI: </strong>10.3969/j.issn.1672-6731.2017.01.002</p> |
topic |
Parkinson disease History of medicine Review |
url |
http://www.cjcnn.org/index.php/cjcnn/article/view/1528 |
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