Evaluation of Interactions of Selected Olivacine Derivatives with DNA and Topoisomerase II

Evaluation of Interactions of Selected Olivacine Derivatives with DNA and Topoisomerase II

Olivacine and ellipticine are model anticancer drugs acting as topoisomerase II inhibitors. Here, we present investigations performed on four olivacine derivatives in light of their antitumor activity. The aim of this study was to identify the best antitumor compound among the four tested olivacine...

Full description

Bibliographic Details
Main Authors: Beata Tylińska, Agnieszka Dobosz, Jan Spychała, Łucja Cwynar-Zając, Żaneta Czyżnikowska, Amadeusz Kuźniarski, Tomasz Gębarowski
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:International Journal of Molecular Sciences
Subjects:
comet assay
polarography
pyridocarbazoles
etoposide
olivacine derivatives
histone acetylation
Online Access:https://www.mdpi.com/1422-0067/22/16/8492

Similar Items

Similar Items