Obesogenic high-fat diet heightens aerobic glycolysis through hyperactivation of oncogenic KRAS
Abstract Oncogenic KRAS plays a vital role in controlling tumor metabolism by enhancing aerobic glycolysis. Obesity driven by chronic consumption of high-fat diet (HFD) is a major risk factor for oncogenic KRAS-mediated pancreatic ductal adenocarcinoma (PDAC). However, the role of HFD in KRAS-mediat...
Main Authors: | Dan Wang, Yawei Bi, Lianghao Hu, Yongde Luo, Juntao Ji, Albert Z. Mao, Craig D. Logsdon, Ellen Li, James L. Abbruzzese, Zhaoshen Li, Vincent W. Yang, Weiqin Lu |
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Format: | Article |
Language: | English |
Published: |
BMC
2019-02-01
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Series: | Cell Communication and Signaling |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s12964-019-0333-7 |
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