The Firre locus produces a trans-acting RNA molecule that functions in hematopoiesis
LncRNA loci potentially contain multiple modes that can exert function, including DNA regulatory elements. Here, the authors generated genetic models in mice to dissect the role of the syntenically conserved lncRNA Firre in the context of hematopoiesis.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2019-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-12970-4 |
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doaj-ae0f94d7e6434786ac485113730f81c42021-05-11T11:55:36ZengNature Publishing GroupNature Communications2041-17232019-11-0110111310.1038/s41467-019-12970-4The Firre locus produces a trans-acting RNA molecule that functions in hematopoiesisJordan P. Lewandowski0James C. Lee1Taeyoung Hwang2Hongjae Sunwoo3Jill M. Goldstein4Abigail F. Groff5Nydia P. Chang6William Mallard7Adam Williams8Jorge Henao-Meija9Richard A. Flavell10Jeannie T. Lee11Chiara Gerhardinger12Amy J. Wagers13John L. Rinn14Department of Stem Cell and Regenerative Biology and Harvard Stem Cell Institute, Harvard UniversityDepartment of Stem Cell and Regenerative Biology and Harvard Stem Cell Institute, Harvard UniversityDepartment of Stem Cell and Regenerative Biology and Harvard Stem Cell Institute, Harvard UniversityDepartment of Molecular Biology, Massachusetts General HospitalDepartment of Stem Cell and Regenerative Biology and Harvard Stem Cell Institute, Harvard UniversityDepartment of Stem Cell and Regenerative Biology and Harvard Stem Cell Institute, Harvard UniversityDepartment of Stem Cell and Regenerative Biology and Harvard Stem Cell Institute, Harvard UniversityDepartment of Stem Cell and Regenerative Biology and Harvard Stem Cell Institute, Harvard UniversityThe Jackson Laboratory, JAX Genomic MedicineDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine University of PennsylvaniaDepartment of Immunobiology and Howard Hughes Medical Institute, Yale University, School of MedicineDepartment of Molecular Biology, Massachusetts General HospitalDepartment of Stem Cell and Regenerative Biology and Harvard Stem Cell Institute, Harvard UniversityDepartment of Stem Cell and Regenerative Biology and Harvard Stem Cell Institute, Harvard UniversityDepartment of Stem Cell and Regenerative Biology and Harvard Stem Cell Institute, Harvard UniversityLncRNA loci potentially contain multiple modes that can exert function, including DNA regulatory elements. Here, the authors generated genetic models in mice to dissect the role of the syntenically conserved lncRNA Firre in the context of hematopoiesis.https://doi.org/10.1038/s41467-019-12970-4 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Jordan P. Lewandowski James C. Lee Taeyoung Hwang Hongjae Sunwoo Jill M. Goldstein Abigail F. Groff Nydia P. Chang William Mallard Adam Williams Jorge Henao-Meija Richard A. Flavell Jeannie T. Lee Chiara Gerhardinger Amy J. Wagers John L. Rinn |
| spellingShingle |
Jordan P. Lewandowski James C. Lee Taeyoung Hwang Hongjae Sunwoo Jill M. Goldstein Abigail F. Groff Nydia P. Chang William Mallard Adam Williams Jorge Henao-Meija Richard A. Flavell Jeannie T. Lee Chiara Gerhardinger Amy J. Wagers John L. Rinn The Firre locus produces a trans-acting RNA molecule that functions in hematopoiesis Nature Communications |
| author_facet |
Jordan P. Lewandowski James C. Lee Taeyoung Hwang Hongjae Sunwoo Jill M. Goldstein Abigail F. Groff Nydia P. Chang William Mallard Adam Williams Jorge Henao-Meija Richard A. Flavell Jeannie T. Lee Chiara Gerhardinger Amy J. Wagers John L. Rinn |
| author_sort |
Jordan P. Lewandowski |
| title |
The Firre locus produces a trans-acting RNA molecule that functions in hematopoiesis |
| title_short |
The Firre locus produces a trans-acting RNA molecule that functions in hematopoiesis |
| title_full |
The Firre locus produces a trans-acting RNA molecule that functions in hematopoiesis |
| title_fullStr |
The Firre locus produces a trans-acting RNA molecule that functions in hematopoiesis |
| title_full_unstemmed |
The Firre locus produces a trans-acting RNA molecule that functions in hematopoiesis |
| title_sort |
firre locus produces a trans-acting rna molecule that functions in hematopoiesis |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2019-11-01 |
| description |
LncRNA loci potentially contain multiple modes that can exert function, including DNA regulatory elements. Here, the authors generated genetic models in mice to dissect the role of the syntenically conserved lncRNA Firre in the context of hematopoiesis. |
| url |
https://doi.org/10.1038/s41467-019-12970-4 |
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