Resistance in tuberculosis: What do we know and where can we go?

Resistance in tuberculosis: What do we know and where can we go?

Tuberculosis (TB) has become a worldwide threat, mainly due to the emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains of Mycobacterium tuberculosis (Mtb). This mini-review is focused on the various mechanisms of resistance to the currently available anti-TB drugs and...

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Bibliographic Details
Main Authors: Keith eGreen, Sylvie eGarneau-Tsodikova
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-07-01
Series:Frontiers in Microbiology
Subjects:
inhibitors
antibiotics
mechanisms of resistance
new drug targets
synergistic drug therapy
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2013.00208/full
Description
Summary:Tuberculosis (TB) has become a worldwide threat, mainly due to the emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains of Mycobacterium tuberculosis (Mtb). This mini-review is focused on the various mechanisms of resistance to the currently available anti-TB drugs and provides perspective on novel strategies and lead scaffolds/compounds aimed at inhibiting/overcoming these resistance mechanisms.
ISSN:1664-302X

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