The Relationship Between Postmenopausal Osteoporosis and Autophagic Gene Polymorphisms
Objective:This study investigates the role of ATG16L1 rs2241880, ATG10 rs1864183 and ATG5 rs2245214 gene polymorphisms, which are involved in autophagosome formation, in the susceptibility to postmenopausal osteoporosis (PMO) disease.Materials and Methods:Hundred PMO patients and 100 healthy control...
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Galenos Yayinevi
2020-08-01
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http://www.turkosteoporozdergisi.org/archives/archive-detail/article-preview/the-relationship-between-postmenopausal-osteoporos/40113
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doaj-ae17013426c4479baf3689d8831aa69e2020-11-25T03:09:37ZengGalenos YayineviTürk Osteoporoz Dergisi2147-26532147-26532020-08-0126212713110.4274/tod.galenos.2020.5823413049054The Relationship Between Postmenopausal Osteoporosis and Autophagic Gene PolymorphismsTürkan Turgay0Elif Pala1Filiz Özbaş Gerçeker2Savaş Gürsoy3Özlem Altındağ4Ali Aydeniz5 SANKO University, Sani Konukoğlu Practice and Research Hospital, Clinic of Physical Medicine and Rehabilitation, Gaziantep, Turkey SANKO University Faculty of Medicine, Department of Medical Biology, Gaziantep, Turkey Gaziantep University Faculty of Arts and Science, Department of Biology, Division of Molecular Biology, Gaziantep, Turkey Gaziantep University Faculty of Medicine, Department of Physical Medicine and Rehabilitation, Gaziantep, Turkey Gaziantep University Faculty of Medicine, Department of Physical Medicine and Rehabilitation, Gaziantep, Turkey Gaziantep University Faculty of Medicine, Department of Physical Medicine and Rehabilitation, Gaziantep, Turkey Objective:This study investigates the role of ATG16L1 rs2241880, ATG10 rs1864183 and ATG5 rs2245214 gene polymorphisms, which are involved in autophagosome formation, in the susceptibility to postmenopausal osteoporosis (PMO) disease.Materials and Methods:Hundred PMO patients and 100 healthy controls without PMO were included into the study. The distribution of the genotypes of ATG16L1 rs2241880, ATG10 rs1864183 and ATG5 rs2245214 polymorphisms in these subjects were analyzed using the TaqMan 5´-exonuclease allelic discrimination assay.Results:The T allele was detected more frequent among patients with osteoporosis (53%) of the ATG10 rs1864183 polymorphism. C allele in ATG16L1 rs2241880 polymorphism in the group of patients with osteoporosis was observed more frequent (56.5%). Besides, the G allele of the ATG5 rs2245214 polymorphism was identified more common in PMO (34%) than in control group. However, no significant difference were detected in genotype and allele frequencies in terms of these polymorphisms between the patient and the control groups (p>0.05).Conclusion:In summary, the results of our study do not support the hypothesis that ATG16L1 rs2241880, ATG10 rs1864183 and ATG5 rs2245214 polymorphisms influence the predisposition for osteoporosis in postmenopausal women. http://www.turkosteoporozdergisi.org/archives/archive-detail/article-preview/the-relationship-between-postmenopausal-osteoporos/40113 autophagygene polymorphismpostmenopausal osteoporosis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Türkan Turgay Elif Pala Filiz Özbaş Gerçeker Savaş Gürsoy Özlem Altındağ Ali Aydeniz |
spellingShingle |
Türkan Turgay Elif Pala Filiz Özbaş Gerçeker Savaş Gürsoy Özlem Altındağ Ali Aydeniz The Relationship Between Postmenopausal Osteoporosis and Autophagic Gene Polymorphisms Türk Osteoporoz Dergisi autophagy gene polymorphism postmenopausal osteoporosis |
author_facet |
Türkan Turgay Elif Pala Filiz Özbaş Gerçeker Savaş Gürsoy Özlem Altındağ Ali Aydeniz |
author_sort |
Türkan Turgay |
title |
The Relationship Between Postmenopausal Osteoporosis and Autophagic Gene Polymorphisms |
title_short |
The Relationship Between Postmenopausal Osteoporosis and Autophagic Gene Polymorphisms |
title_full |
The Relationship Between Postmenopausal Osteoporosis and Autophagic Gene Polymorphisms |
title_fullStr |
The Relationship Between Postmenopausal Osteoporosis and Autophagic Gene Polymorphisms |
title_full_unstemmed |
The Relationship Between Postmenopausal Osteoporosis and Autophagic Gene Polymorphisms |
title_sort |
relationship between postmenopausal osteoporosis and autophagic gene polymorphisms |
publisher |
Galenos Yayinevi |
series |
Türk Osteoporoz Dergisi |
issn |
2147-2653 2147-2653 |
publishDate |
2020-08-01 |
description |
Objective:This study investigates the role of ATG16L1 rs2241880, ATG10 rs1864183 and ATG5 rs2245214 gene polymorphisms, which are involved in autophagosome formation, in the susceptibility to postmenopausal osteoporosis (PMO) disease.Materials and Methods:Hundred PMO patients and 100 healthy controls without PMO were included into the study. The distribution of the genotypes of ATG16L1 rs2241880, ATG10 rs1864183 and ATG5 rs2245214 polymorphisms in these subjects were analyzed using the TaqMan 5´-exonuclease allelic discrimination assay.Results:The T allele was detected more frequent among patients with osteoporosis (53%) of the ATG10 rs1864183 polymorphism. C allele in ATG16L1 rs2241880 polymorphism in the group of patients with osteoporosis was observed more frequent (56.5%). Besides, the G allele of the ATG5 rs2245214 polymorphism was identified more common in PMO (34%) than in control group. However, no significant difference were detected in genotype and allele frequencies in terms of these polymorphisms between the patient and the control groups (p>0.05).Conclusion:In summary, the results of our study do not support the hypothesis that ATG16L1 rs2241880, ATG10 rs1864183 and ATG5 rs2245214 polymorphisms influence the predisposition for osteoporosis in postmenopausal women. |
topic |
autophagy gene polymorphism postmenopausal osteoporosis |
url |
http://www.turkosteoporozdergisi.org/archives/archive-detail/article-preview/the-relationship-between-postmenopausal-osteoporos/40113
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