Metal-Organic Framework (MOF)-Based Biomaterials for Tissue Engineering and Regenerative Medicine
The synthesis of Metal-organic Frameworks (MOFs) and their evaluation for various applications is one of the largest research areas within materials sciences and chemistry. Here, the use of MOFs in biomaterials and implants is summarized as narrative review addressing primarely the Tissue Engineerin...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2021-03-01
|
Series: | Frontiers in Bioengineering and Biotechnology |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2021.603608/full |
id |
doaj-ae18ec7c451e409f9915077d2ff4e9a0 |
---|---|
record_format |
Article |
spelling |
doaj-ae18ec7c451e409f9915077d2ff4e9a02021-03-11T05:59:43ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852021-03-01910.3389/fbioe.2021.603608603608Metal-Organic Framework (MOF)-Based Biomaterials for Tissue Engineering and Regenerative MedicineMoldir Shyngys0Jia Ren1Xiaoqi Liang2Jiechen Miao3Anna Blocki4Anna Blocki5Anna Blocki6Sebastian Beyer7Sebastian Beyer8Department of Biomedical Engineering, The Chinese University of Hong Kong, Shatin, Hong KongDepartment of Biomedical Engineering, The Chinese University of Hong Kong, Shatin, Hong KongDepartment of Biomedical Engineering, The Chinese University of Hong Kong, Shatin, Hong KongDepartment of Biomedical Engineering, The Chinese University of Hong Kong, Shatin, Hong KongInstitute for Tissue Engineering & Regenerative Medicine, The Chinese University of Hong Kong, Shatin, Hong KongSchool of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong KongDepartment of Orthopaedics & Traumatology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong KongDepartment of Biomedical Engineering, The Chinese University of Hong Kong, Shatin, Hong KongInstitute for Tissue Engineering & Regenerative Medicine, The Chinese University of Hong Kong, Shatin, Hong KongThe synthesis of Metal-organic Frameworks (MOFs) and their evaluation for various applications is one of the largest research areas within materials sciences and chemistry. Here, the use of MOFs in biomaterials and implants is summarized as narrative review addressing primarely the Tissue Engineering and Regenerative Medicine (TERM) community. Focus is given on MOFs as bioactive component to aid tissue engineering and to augment clinically established or future therapies in regenerative medicine. A summary of synthesis methods suitable for TERM laboratories and key properties of MOFs relevant to biomaterials is provided. The use of MOFs is categorized according to their targeted organ (bone, cardio-vascular, skin and nervous tissue) and whether the MOFs are used as intrinsically bioactive material or as drug delivery vehicle. Further distinction between in vitro and in vivo studies provides a clear assessment of literature on the current progress of MOF based biomaterials. Although the present review is narrative in nature, systematic literature analysis has been performed, allowing a concise overview of this emerging research direction till the point of writing. While a number of excellent studies have been published, future studies will need to clearly highlight the safety and added value of MOFs compared to established materials for clinical TERM applications. The scope of the present review is clearly delimited from the general ‘biomedical application’ of MOFs that focuses mainly on drug delivery or diagnostic applications not involving aspects of tissue healing or better implant integration.https://www.frontiersin.org/articles/10.3389/fbioe.2021.603608/fullmetal-organic frameworksbiomaterialtissue engineeringregenerative medicinebonecardio-vascular |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Moldir Shyngys Jia Ren Xiaoqi Liang Jiechen Miao Anna Blocki Anna Blocki Anna Blocki Sebastian Beyer Sebastian Beyer |
spellingShingle |
Moldir Shyngys Jia Ren Xiaoqi Liang Jiechen Miao Anna Blocki Anna Blocki Anna Blocki Sebastian Beyer Sebastian Beyer Metal-Organic Framework (MOF)-Based Biomaterials for Tissue Engineering and Regenerative Medicine Frontiers in Bioengineering and Biotechnology metal-organic frameworks biomaterial tissue engineering regenerative medicine bone cardio-vascular |
author_facet |
Moldir Shyngys Jia Ren Xiaoqi Liang Jiechen Miao Anna Blocki Anna Blocki Anna Blocki Sebastian Beyer Sebastian Beyer |
author_sort |
Moldir Shyngys |
title |
Metal-Organic Framework (MOF)-Based Biomaterials for Tissue Engineering and Regenerative Medicine |
title_short |
Metal-Organic Framework (MOF)-Based Biomaterials for Tissue Engineering and Regenerative Medicine |
title_full |
Metal-Organic Framework (MOF)-Based Biomaterials for Tissue Engineering and Regenerative Medicine |
title_fullStr |
Metal-Organic Framework (MOF)-Based Biomaterials for Tissue Engineering and Regenerative Medicine |
title_full_unstemmed |
Metal-Organic Framework (MOF)-Based Biomaterials for Tissue Engineering and Regenerative Medicine |
title_sort |
metal-organic framework (mof)-based biomaterials for tissue engineering and regenerative medicine |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Bioengineering and Biotechnology |
issn |
2296-4185 |
publishDate |
2021-03-01 |
description |
The synthesis of Metal-organic Frameworks (MOFs) and their evaluation for various applications is one of the largest research areas within materials sciences and chemistry. Here, the use of MOFs in biomaterials and implants is summarized as narrative review addressing primarely the Tissue Engineering and Regenerative Medicine (TERM) community. Focus is given on MOFs as bioactive component to aid tissue engineering and to augment clinically established or future therapies in regenerative medicine. A summary of synthesis methods suitable for TERM laboratories and key properties of MOFs relevant to biomaterials is provided. The use of MOFs is categorized according to their targeted organ (bone, cardio-vascular, skin and nervous tissue) and whether the MOFs are used as intrinsically bioactive material or as drug delivery vehicle. Further distinction between in vitro and in vivo studies provides a clear assessment of literature on the current progress of MOF based biomaterials. Although the present review is narrative in nature, systematic literature analysis has been performed, allowing a concise overview of this emerging research direction till the point of writing. While a number of excellent studies have been published, future studies will need to clearly highlight the safety and added value of MOFs compared to established materials for clinical TERM applications. The scope of the present review is clearly delimited from the general ‘biomedical application’ of MOFs that focuses mainly on drug delivery or diagnostic applications not involving aspects of tissue healing or better implant integration. |
topic |
metal-organic frameworks biomaterial tissue engineering regenerative medicine bone cardio-vascular |
url |
https://www.frontiersin.org/articles/10.3389/fbioe.2021.603608/full |
work_keys_str_mv |
AT moldirshyngys metalorganicframeworkmofbasedbiomaterialsfortissueengineeringandregenerativemedicine AT jiaren metalorganicframeworkmofbasedbiomaterialsfortissueengineeringandregenerativemedicine AT xiaoqiliang metalorganicframeworkmofbasedbiomaterialsfortissueengineeringandregenerativemedicine AT jiechenmiao metalorganicframeworkmofbasedbiomaterialsfortissueengineeringandregenerativemedicine AT annablocki metalorganicframeworkmofbasedbiomaterialsfortissueengineeringandregenerativemedicine AT annablocki metalorganicframeworkmofbasedbiomaterialsfortissueengineeringandregenerativemedicine AT annablocki metalorganicframeworkmofbasedbiomaterialsfortissueengineeringandregenerativemedicine AT sebastianbeyer metalorganicframeworkmofbasedbiomaterialsfortissueengineeringandregenerativemedicine AT sebastianbeyer metalorganicframeworkmofbasedbiomaterialsfortissueengineeringandregenerativemedicine |
_version_ |
1724225946914914304 |