Extract from Maize (Zea mays L.): Antibacterial Activity of DIMBOA and Its Derivatives against Ralstonia solanacearum
Many cereals accumulate hydroxamic acids involved in defense of plant against various fungi, bacteria, and insects. 2,4-dihydroxy-7-methoxy-1,4-benzoxazine-3-one, commonly known as DIMBOA, is one of the principal cyclic hydroxamic acids in aqueous extracts of maize. The aim of this study was to eval...
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2016-10-01
|
Series: | Molecules |
Subjects: | |
Online Access: | http://www.mdpi.com/1420-3049/21/10/1397 |
id |
doaj-ae19943b50684e49975b22584bf9676f |
---|---|
record_format |
Article |
spelling |
doaj-ae19943b50684e49975b22584bf9676f2020-11-24T23:19:47ZengMDPI AGMolecules1420-30492016-10-012110139710.3390/molecules21101397molecules21101397Extract from Maize (Zea mays L.): Antibacterial Activity of DIMBOA and Its Derivatives against Ralstonia solanacearumBing Guo0Yongqiang Zhang1Shili Li2Ting Lai3Liang Yang4Juanni Chen5Wei Ding6Laboratory of Natural Products Pesticides, College of Plant Protection, Southwest University, Chongqing 400715, ChinaLaboratory of Natural Products Pesticides, College of Plant Protection, Southwest University, Chongqing 400715, ChinaLaboratory of Natural Products Pesticides, College of Plant Protection, Southwest University, Chongqing 400715, ChinaLaboratory of Natural Products Pesticides, College of Plant Protection, Southwest University, Chongqing 400715, ChinaLaboratory of Natural Products Pesticides, College of Plant Protection, Southwest University, Chongqing 400715, ChinaLaboratory of Natural Products Pesticides, College of Plant Protection, Southwest University, Chongqing 400715, ChinaLaboratory of Natural Products Pesticides, College of Plant Protection, Southwest University, Chongqing 400715, ChinaMany cereals accumulate hydroxamic acids involved in defense of plant against various fungi, bacteria, and insects. 2,4-dihydroxy-7-methoxy-1,4-benzoxazine-3-one, commonly known as DIMBOA, is one of the principal cyclic hydroxamic acids in aqueous extracts of maize. The aim of this study was to evaluate the antibacterial activity of the isolated DIMBOA and its derivatives 2-benzoxazolinone (BOA), 6-chloro-2-benzoxazolinone (CDHB), and 2-mercaptobenzothiazole (MBT) against Ralstonia solanacearum. MBT showed the strongest antibacterial activity, followed by CDHB and DIMBOA, with minimum inhibitory concentrations (MICs) of 50, 100 and 200 mg/L, respectively, better than the BOA with 300 mg/L. These compounds also significantly affect bacterial growth, reduce biofilm formation, and inhibit swarming motility within 24 h. This paper is the first to report the anti-R. solanacearum activity of DIMBOA from Z. mays. The bioassay and pot experiment results suggested that DIMBOA and its derivatives exhibit potential as a new matrix structure of designing target bactericide or elicitor for controlling tobacco bacterial wilt. Further studies must evaluate the efficacy of DIMBOA and its derivatives in controlling bacterial wilt under natural field conditions where low inoculum concentrations exist.http://www.mdpi.com/1420-3049/21/10/1397DIMBOARalstonia solanacearumantibacterial activitybiofilm inhibitionbacterial wilt |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Bing Guo Yongqiang Zhang Shili Li Ting Lai Liang Yang Juanni Chen Wei Ding |
spellingShingle |
Bing Guo Yongqiang Zhang Shili Li Ting Lai Liang Yang Juanni Chen Wei Ding Extract from Maize (Zea mays L.): Antibacterial Activity of DIMBOA and Its Derivatives against Ralstonia solanacearum Molecules DIMBOA Ralstonia solanacearum antibacterial activity biofilm inhibition bacterial wilt |
author_facet |
Bing Guo Yongqiang Zhang Shili Li Ting Lai Liang Yang Juanni Chen Wei Ding |
author_sort |
Bing Guo |
title |
Extract from Maize (Zea mays L.): Antibacterial Activity of DIMBOA and Its Derivatives against Ralstonia solanacearum |
title_short |
Extract from Maize (Zea mays L.): Antibacterial Activity of DIMBOA and Its Derivatives against Ralstonia solanacearum |
title_full |
Extract from Maize (Zea mays L.): Antibacterial Activity of DIMBOA and Its Derivatives against Ralstonia solanacearum |
title_fullStr |
Extract from Maize (Zea mays L.): Antibacterial Activity of DIMBOA and Its Derivatives against Ralstonia solanacearum |
title_full_unstemmed |
Extract from Maize (Zea mays L.): Antibacterial Activity of DIMBOA and Its Derivatives against Ralstonia solanacearum |
title_sort |
extract from maize (zea mays l.): antibacterial activity of dimboa and its derivatives against ralstonia solanacearum |
publisher |
MDPI AG |
series |
Molecules |
issn |
1420-3049 |
publishDate |
2016-10-01 |
description |
Many cereals accumulate hydroxamic acids involved in defense of plant against various fungi, bacteria, and insects. 2,4-dihydroxy-7-methoxy-1,4-benzoxazine-3-one, commonly known as DIMBOA, is one of the principal cyclic hydroxamic acids in aqueous extracts of maize. The aim of this study was to evaluate the antibacterial activity of the isolated DIMBOA and its derivatives 2-benzoxazolinone (BOA), 6-chloro-2-benzoxazolinone (CDHB), and 2-mercaptobenzothiazole (MBT) against Ralstonia solanacearum. MBT showed the strongest antibacterial activity, followed by CDHB and DIMBOA, with minimum inhibitory concentrations (MICs) of 50, 100 and 200 mg/L, respectively, better than the BOA with 300 mg/L. These compounds also significantly affect bacterial growth, reduce biofilm formation, and inhibit swarming motility within 24 h. This paper is the first to report the anti-R. solanacearum activity of DIMBOA from Z. mays. The bioassay and pot experiment results suggested that DIMBOA and its derivatives exhibit potential as a new matrix structure of designing target bactericide or elicitor for controlling tobacco bacterial wilt. Further studies must evaluate the efficacy of DIMBOA and its derivatives in controlling bacterial wilt under natural field conditions where low inoculum concentrations exist. |
topic |
DIMBOA Ralstonia solanacearum antibacterial activity biofilm inhibition bacterial wilt |
url |
http://www.mdpi.com/1420-3049/21/10/1397 |
work_keys_str_mv |
AT bingguo extractfrommaizezeamayslantibacterialactivityofdimboaanditsderivativesagainstralstoniasolanacearum AT yongqiangzhang extractfrommaizezeamayslantibacterialactivityofdimboaanditsderivativesagainstralstoniasolanacearum AT shilili extractfrommaizezeamayslantibacterialactivityofdimboaanditsderivativesagainstralstoniasolanacearum AT tinglai extractfrommaizezeamayslantibacterialactivityofdimboaanditsderivativesagainstralstoniasolanacearum AT liangyang extractfrommaizezeamayslantibacterialactivityofdimboaanditsderivativesagainstralstoniasolanacearum AT juannichen extractfrommaizezeamayslantibacterialactivityofdimboaanditsderivativesagainstralstoniasolanacearum AT weiding extractfrommaizezeamayslantibacterialactivityofdimboaanditsderivativesagainstralstoniasolanacearum |
_version_ |
1725576872997158912 |