Ileo-Colon Targeting of the Poorly Water-Soluble Drug Celecoxib Using a pH-Dependent Coating in Combination with Self-Emulsifying Drug Delivery or Solid Dispersion Systems

Ileo-Colon Targeting of the Poorly Water-Soluble Drug Celecoxib Using a pH-Dependent Coating in Combination with Self-Emulsifying Drug Delivery or Solid Dispersion Systems

Targeting celecoxib to the ileo-colonic region could be beneficial for the treatment and prevention of colon cancer. Ileo-colonic targeting can be achieved by using pH-dependent coating systems such as ColoPulse. Celecoxib has poor aqueous solubility, which may jeopardize optimal treatment. Therefor...

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Bibliographic Details
Main Authors: Annemarie Broesder, Julia M. E. Berends, Sophie M. Scheepers, Duong N. Nguyen, Henderik W. Frijlink, Wouter L. J. Hinrichs
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Pharmaceutics
Subjects:
ileo-colonic drug delivery
supersaturation
film coating
BCS class II drug
delayed release
ColoPulse
Online Access:https://www.mdpi.com/1999-4923/13/5/731

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