| Summary: | Wei Tang,1 Huifeng Zhu2 *,* Yanmei Feng,3 Rui Guo,1 Dong Wan1 ** 1Department of Emergency & Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, People’s Republic of China; 2College of Pharmaceutical Sciences & Chinese Medicine, Southwest University, Chongqing 400716, People’s Republic of China; 3Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, People’s Republic of China*These authors contributed equally to this workCorrespondence: Huifeng ZhuCollege of Pharmaceutical Sciences & Chinese Medicine, Southwest University, Chongqing 400716, People’s Republic of ChinaEmail zhfbsci@126.comDong WanDepartment of Emergency & Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, People’s Republic of ChinaEmail wandongcqykdx@126.comAbstract: The gut microbiota is symbiotic with the human host and has been extensively studied in recent years resulting in increasing awareness of the effects of the gut microbiota on human health. In this review, we summarize the current evidence for the effects of gut microbes on the integrity of the cerebral blood–brain barrier (BBB), focusing on the pathogenic impact of gut microbiota disorders. Based on our description and summarization of the effects of the gut microbiota and its metabolites on the nervous, endocrine, and immune systems and related signaling pathways and the resulting destruction of the BBB, we suggest that regulating and supplementing the intestinal microbiota as well as targeting immune cells and inflammatory mediators are required to protect the BBB.Keywords: microbiota, metabolites, blood–brain barrier
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