Symptomatic Therapy and Rehabilitation in Primary Progressive Multiple Sclerosis
Multiple sclerosis (MS) is an autoimmune inflammatory demyelinating disease of the central nervous system and a major cause of chronic neurological disability in young adults. Primary progressive MS (PPMS) constitutes about 10% of cases, and is characterized by a steady decline in function with no a...
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doaj-ae1f2934ea4f4d30922ea1c59af28b282020-11-24T21:34:00ZengHindawi LimitedNeurology Research International2090-18522090-18602011-01-01201110.1155/2011/740505740505Symptomatic Therapy and Rehabilitation in Primary Progressive Multiple SclerosisFary Khan0Bhasker Amatya1Lynne Turner-Stokes2Department of Medicine, Dentistry and Health Sciences at The University of Melbourne, Royal Melbourne Hospital and Western Health, Rehabilitation Service—Royal Melbourne Hospital, Poplar Road, Parkville, Melbourne, VIC 3052, AustraliaDepartment of Rehabilitation Medicine, Royal Melbourne Hospital, 34-54 Poplar Road Parkville, Melbourne, VIC 3052, AustraliaRegional Rehabilitation Unit, Northwick Park Hospital, Watford Road, Harrow, Middlesex HA1 3UJ, UKMultiple sclerosis (MS) is an autoimmune inflammatory demyelinating disease of the central nervous system and a major cause of chronic neurological disability in young adults. Primary progressive MS (PPMS) constitutes about 10% of cases, and is characterized by a steady decline in function with no acute attacks. The rate of deterioration from disease onset is more rapid than relapsing remitting and secondary progressive MS types. Multiple system involvement at onset and rapid early progression have a worse prognosis. PPMS can cause significant disability and impact on quality of life. Recent studies are biased in favour of relapsing remitting patients as treatment is now available for them and they are more likely to be seen at MS clinics. Since prognosis for PPMS is worse than other types of MS, the focus of rehabilitation is on managing disability and enhancing participation, and application of a “neuropalliative” approach as the disease progresses. This chapter presents the symptomatic treatment and rehabilitation for persons with MS, including PPMS. A multidisciplinary approach optimizes the intermediate and long-term medical, psychological and social outcomes in this population. Restoration and maintenance of functional independence and societal reintegration, and issues relating to quality of life are addressed in rehabilitation processes.http://dx.doi.org/10.1155/2011/740505 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Fary Khan Bhasker Amatya Lynne Turner-Stokes |
spellingShingle |
Fary Khan Bhasker Amatya Lynne Turner-Stokes Symptomatic Therapy and Rehabilitation in Primary Progressive Multiple Sclerosis Neurology Research International |
author_facet |
Fary Khan Bhasker Amatya Lynne Turner-Stokes |
author_sort |
Fary Khan |
title |
Symptomatic Therapy and Rehabilitation in Primary Progressive Multiple Sclerosis |
title_short |
Symptomatic Therapy and Rehabilitation in Primary Progressive Multiple Sclerosis |
title_full |
Symptomatic Therapy and Rehabilitation in Primary Progressive Multiple Sclerosis |
title_fullStr |
Symptomatic Therapy and Rehabilitation in Primary Progressive Multiple Sclerosis |
title_full_unstemmed |
Symptomatic Therapy and Rehabilitation in Primary Progressive Multiple Sclerosis |
title_sort |
symptomatic therapy and rehabilitation in primary progressive multiple sclerosis |
publisher |
Hindawi Limited |
series |
Neurology Research International |
issn |
2090-1852 2090-1860 |
publishDate |
2011-01-01 |
description |
Multiple sclerosis (MS) is an autoimmune inflammatory demyelinating disease of the central nervous system and a major cause of chronic neurological disability in young adults. Primary progressive MS (PPMS) constitutes about 10% of cases, and is characterized by a steady decline in function with no acute attacks. The rate of deterioration from disease onset is more rapid than relapsing remitting and secondary progressive MS types. Multiple system involvement at onset and rapid early progression have a worse prognosis. PPMS can cause significant disability and impact on quality of life. Recent studies are biased in favour of relapsing remitting patients as treatment is now available for them and they are more likely to be seen at MS clinics. Since prognosis for PPMS is worse than other types of MS, the focus of rehabilitation is on managing disability and enhancing participation, and application of a “neuropalliative” approach as the disease progresses. This chapter presents the symptomatic treatment and rehabilitation for persons with MS, including PPMS. A multidisciplinary approach optimizes the intermediate and long-term medical, psychological and social outcomes in this population. Restoration and maintenance of functional independence and societal reintegration, and issues relating to quality of life are addressed in rehabilitation processes. |
url |
http://dx.doi.org/10.1155/2011/740505 |
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