High-Throughput Particle Manipulation Based on Hydrodynamic Effects in Microchannels
Microfluidic techniques are effective tools for precise manipulation of particles and cells, whose enrichment and separation is crucial for a wide range of applications in biology, medicine, and chemistry. Recently, lateral particle migration induced by the intrinsic hydrodynamic effects in microcha...
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doaj-ae21b8f2724646b1ba1c738d150cb08f2020-11-24T23:20:08ZengMDPI AGMicromachines2072-666X2017-03-01837310.3390/mi8030073mi8030073High-Throughput Particle Manipulation Based on Hydrodynamic Effects in MicrochannelsChao Liu0Guoqing Hu1CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for NanoScience and Technology, Beijing 100190, ChinaState Key Laboratory of Nonlinear Mechanics, Beijing Key Laboratory of Engineered Construction and Mechanobiology, Institute of Mechanics, Chinese Academy of Sciences, Beijing 100190, ChinaMicrofluidic techniques are effective tools for precise manipulation of particles and cells, whose enrichment and separation is crucial for a wide range of applications in biology, medicine, and chemistry. Recently, lateral particle migration induced by the intrinsic hydrodynamic effects in microchannels, such as inertia and elasticity, has shown its promise for high-throughput and label-free particle manipulation. The particle migration can be engineered to realize the controllable focusing and separation of particles based on a difference in size. The widespread use of inertial and viscoelastic microfluidics depends on the understanding of hydrodynamic effects on particle motion. This review will summarize the progress in the fundamental mechanisms and key applications of inertial and viscoelastic particle manipulation.http://www.mdpi.com/2072-666X/8/3/73particle manipulationinertial liftviscoelastic effectsmicrofluidicslab on a chiphigh throughput |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Chao Liu Guoqing Hu |
spellingShingle |
Chao Liu Guoqing Hu High-Throughput Particle Manipulation Based on Hydrodynamic Effects in Microchannels Micromachines particle manipulation inertial lift viscoelastic effects microfluidics lab on a chip high throughput |
author_facet |
Chao Liu Guoqing Hu |
author_sort |
Chao Liu |
title |
High-Throughput Particle Manipulation Based on Hydrodynamic Effects in Microchannels |
title_short |
High-Throughput Particle Manipulation Based on Hydrodynamic Effects in Microchannels |
title_full |
High-Throughput Particle Manipulation Based on Hydrodynamic Effects in Microchannels |
title_fullStr |
High-Throughput Particle Manipulation Based on Hydrodynamic Effects in Microchannels |
title_full_unstemmed |
High-Throughput Particle Manipulation Based on Hydrodynamic Effects in Microchannels |
title_sort |
high-throughput particle manipulation based on hydrodynamic effects in microchannels |
publisher |
MDPI AG |
series |
Micromachines |
issn |
2072-666X |
publishDate |
2017-03-01 |
description |
Microfluidic techniques are effective tools for precise manipulation of particles and cells, whose enrichment and separation is crucial for a wide range of applications in biology, medicine, and chemistry. Recently, lateral particle migration induced by the intrinsic hydrodynamic effects in microchannels, such as inertia and elasticity, has shown its promise for high-throughput and label-free particle manipulation. The particle migration can be engineered to realize the controllable focusing and separation of particles based on a difference in size. The widespread use of inertial and viscoelastic microfluidics depends on the understanding of hydrodynamic effects on particle motion. This review will summarize the progress in the fundamental mechanisms and key applications of inertial and viscoelastic particle manipulation. |
topic |
particle manipulation inertial lift viscoelastic effects microfluidics lab on a chip high throughput |
url |
http://www.mdpi.com/2072-666X/8/3/73 |
work_keys_str_mv |
AT chaoliu highthroughputparticlemanipulationbasedonhydrodynamiceffectsinmicrochannels AT guoqinghu highthroughputparticlemanipulationbasedonhydrodynamiceffectsinmicrochannels |
_version_ |
1725575845110611968 |