Antimetabolic Effects of Polyphenols in Breast Cancer Cells: Focus on Glucose Uptake and Metabolism
In the last years, metabolic reprogramming became a new key hallmark of tumor cells. One of its components is a deviant energetic metabolism, known as Warburg effect—an aerobic lactatogenesis—characterized by elevated rates of glucose uptake and consumption with high-lactate production even in the p...
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doaj-ae301eed44a846748a2a0ab5d4d53b3d2020-11-24T21:28:21ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2018-04-01510.3389/fnut.2018.00025351588Antimetabolic Effects of Polyphenols in Breast Cancer Cells: Focus on Glucose Uptake and MetabolismElisa Keating0Elisa Keating1Fátima Martel2Fátima Martel3Department of Biomedicine, Unit of Biochemistry, Faculty of Medicine, University of Porto, Porto, PortugalCINTESIS, Center for Research in Health Technologies and Information Systems, University of Porto, Porto, PortugalDepartment of Biomedicine, Unit of Biochemistry, Faculty of Medicine, University of Porto, Porto, PortugalInstituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, PortugalIn the last years, metabolic reprogramming became a new key hallmark of tumor cells. One of its components is a deviant energetic metabolism, known as Warburg effect—an aerobic lactatogenesis—characterized by elevated rates of glucose uptake and consumption with high-lactate production even in the presence of oxygen. Because many cancer cells display a greater sensitivity to glucose deprivation-induced cytotoxicity than normal cells, inhibitors of glucose cellular uptake (facilitative glucose transporter 1 inhibitors) and oxidative metabolism (glycolysis inhibitors) are potential therapeutic targets in cancer treatment. Polyphenols, abundantly contained in fruits and vegetables, are dietary components with an established protective role against cancer. Several molecular mechanisms are involved in the anticancer effect of polyphenols, including effects on apoptosis, cell cycle regulation, plasma membrane receptors, signaling pathways, and epigenetic mechanisms. Additionally, inhibition of glucose cellular uptake and metabolism in cancer cell lines has been described for several polyphenols, and this effect was shown to be associated with their anticarcinogenic effect. This work will review data showing an antimetabolic effect of polyphenols and its involvement in the chemopreventive/chemotherapeutic potential of these dietary compounds, in relation to breast cancer.http://journal.frontiersin.org/article/10.3389/fnut.2018.00025/fullpolyphenolsWarburg effectglucose uptakeglycolysisbreast cancer |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Elisa Keating Elisa Keating Fátima Martel Fátima Martel |
spellingShingle |
Elisa Keating Elisa Keating Fátima Martel Fátima Martel Antimetabolic Effects of Polyphenols in Breast Cancer Cells: Focus on Glucose Uptake and Metabolism Frontiers in Nutrition polyphenols Warburg effect glucose uptake glycolysis breast cancer |
author_facet |
Elisa Keating Elisa Keating Fátima Martel Fátima Martel |
author_sort |
Elisa Keating |
title |
Antimetabolic Effects of Polyphenols in Breast Cancer Cells: Focus on Glucose Uptake and Metabolism |
title_short |
Antimetabolic Effects of Polyphenols in Breast Cancer Cells: Focus on Glucose Uptake and Metabolism |
title_full |
Antimetabolic Effects of Polyphenols in Breast Cancer Cells: Focus on Glucose Uptake and Metabolism |
title_fullStr |
Antimetabolic Effects of Polyphenols in Breast Cancer Cells: Focus on Glucose Uptake and Metabolism |
title_full_unstemmed |
Antimetabolic Effects of Polyphenols in Breast Cancer Cells: Focus on Glucose Uptake and Metabolism |
title_sort |
antimetabolic effects of polyphenols in breast cancer cells: focus on glucose uptake and metabolism |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Nutrition |
issn |
2296-861X |
publishDate |
2018-04-01 |
description |
In the last years, metabolic reprogramming became a new key hallmark of tumor cells. One of its components is a deviant energetic metabolism, known as Warburg effect—an aerobic lactatogenesis—characterized by elevated rates of glucose uptake and consumption with high-lactate production even in the presence of oxygen. Because many cancer cells display a greater sensitivity to glucose deprivation-induced cytotoxicity than normal cells, inhibitors of glucose cellular uptake (facilitative glucose transporter 1 inhibitors) and oxidative metabolism (glycolysis inhibitors) are potential therapeutic targets in cancer treatment. Polyphenols, abundantly contained in fruits and vegetables, are dietary components with an established protective role against cancer. Several molecular mechanisms are involved in the anticancer effect of polyphenols, including effects on apoptosis, cell cycle regulation, plasma membrane receptors, signaling pathways, and epigenetic mechanisms. Additionally, inhibition of glucose cellular uptake and metabolism in cancer cell lines has been described for several polyphenols, and this effect was shown to be associated with their anticarcinogenic effect. This work will review data showing an antimetabolic effect of polyphenols and its involvement in the chemopreventive/chemotherapeutic potential of these dietary compounds, in relation to breast cancer. |
topic |
polyphenols Warburg effect glucose uptake glycolysis breast cancer |
url |
http://journal.frontiersin.org/article/10.3389/fnut.2018.00025/full |
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