SYNTHESIS OF SOME N-(BENZOTHIAZOL-2-YL)-2-(4H-[1,2,4]TRIAZOL -3- YLSULFANYL)ACETAMIDES AND THEIR ANTIMICROBIAL ACTIVITY
The aim of this study is to synthesize novel benzothiazolyl-amide derivatives and investigate their antimicrobial activities. N-(Benzothiazol-2-yl)-2-(4H-[1,2,4]triazol-3-ylsulfanyl) acetamide deriva- tives (3a-j) were prepared by the reaction of N-(benzothiazol-2-yl)-2-chloroacetamides (1a-e) with...
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doaj-ae3ae6b6cb234a0a8ce2fe4aefd96fce2020-11-24T23:48:42ZengAnadolu UniversityAnadolu University Journal of Science and Technology - C. Life Sciences and Biotechnology2146-02642146-02132011-08-0112145151SYNTHESIS OF SOME N-(BENZOTHIAZOL-2-YL)-2-(4H-[1,2,4]TRIAZOL -3- YLSULFANYL)ACETAMIDES AND THEIR ANTIMICROBIAL ACTIVITYMehlika Dilek ALTINTOPGülhan TURAN ZITOUNIZafer Asım KAPLANCIKLIAhmet ÖZDEMİRFatih DEMİRCIThe aim of this study is to synthesize novel benzothiazolyl-amide derivatives and investigate their antimicrobial activities. N-(Benzothiazol-2-yl)-2-(4H-[1,2,4]triazol-3-ylsulfanyl) acetamide deriva- tives (3a-j) were prepared by the reaction of N-(benzothiazol-2-yl)-2-chloroacetamides (1a-e) with appropriate 4H-[1,2,4]triazol-2-thione (2a-b). The chemical structures of the compounds were eluci- dated by elemental analyses, IR, ¹H-NMR, ¹³C-NMR and FAB+-MS spectral data. Their antimicrobial activities against Escherichia coli (NRRL B-3008), Staphylococcus aureus (ATCC 6538), Pseudomo- nas aeruginosa (ATCC 27853), Proteus vulgaris (NRRL B-123), Salmonella typhimurium (ATCC 13311), Methicillin-resistant Staphylococcus aureus (MRSA) (clinic isolate), Candida albicans (NRRL Y-12983) and Candida parapsilosis (NRRL Y-12696) were investigated. The results showed that all of the tested compounds were inactive against the test organismshttp://btd.anadolu.edu.tr/index.php/BTDC/article/viewFile/5/58BenzothiazoleTriazoleAntimicrobial activity |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mehlika Dilek ALTINTOP Gülhan TURAN ZITOUNI Zafer Asım KAPLANCIKLI Ahmet ÖZDEMİR Fatih DEMİRCI |
spellingShingle |
Mehlika Dilek ALTINTOP Gülhan TURAN ZITOUNI Zafer Asım KAPLANCIKLI Ahmet ÖZDEMİR Fatih DEMİRCI SYNTHESIS OF SOME N-(BENZOTHIAZOL-2-YL)-2-(4H-[1,2,4]TRIAZOL -3- YLSULFANYL)ACETAMIDES AND THEIR ANTIMICROBIAL ACTIVITY Anadolu University Journal of Science and Technology - C. Life Sciences and Biotechnology Benzothiazole Triazole Antimicrobial activity |
author_facet |
Mehlika Dilek ALTINTOP Gülhan TURAN ZITOUNI Zafer Asım KAPLANCIKLI Ahmet ÖZDEMİR Fatih DEMİRCI |
author_sort |
Mehlika Dilek ALTINTOP |
title |
SYNTHESIS OF SOME N-(BENZOTHIAZOL-2-YL)-2-(4H-[1,2,4]TRIAZOL -3- YLSULFANYL)ACETAMIDES AND THEIR ANTIMICROBIAL ACTIVITY |
title_short |
SYNTHESIS OF SOME N-(BENZOTHIAZOL-2-YL)-2-(4H-[1,2,4]TRIAZOL -3- YLSULFANYL)ACETAMIDES AND THEIR ANTIMICROBIAL ACTIVITY |
title_full |
SYNTHESIS OF SOME N-(BENZOTHIAZOL-2-YL)-2-(4H-[1,2,4]TRIAZOL -3- YLSULFANYL)ACETAMIDES AND THEIR ANTIMICROBIAL ACTIVITY |
title_fullStr |
SYNTHESIS OF SOME N-(BENZOTHIAZOL-2-YL)-2-(4H-[1,2,4]TRIAZOL -3- YLSULFANYL)ACETAMIDES AND THEIR ANTIMICROBIAL ACTIVITY |
title_full_unstemmed |
SYNTHESIS OF SOME N-(BENZOTHIAZOL-2-YL)-2-(4H-[1,2,4]TRIAZOL -3- YLSULFANYL)ACETAMIDES AND THEIR ANTIMICROBIAL ACTIVITY |
title_sort |
synthesis of some n-(benzothiazol-2-yl)-2-(4h-[1,2,4]triazol -3- ylsulfanyl)acetamides and their antimicrobial activity |
publisher |
Anadolu University |
series |
Anadolu University Journal of Science and Technology - C. Life Sciences and Biotechnology |
issn |
2146-0264 2146-0213 |
publishDate |
2011-08-01 |
description |
The aim of this study is to synthesize novel benzothiazolyl-amide derivatives and investigate their antimicrobial activities. N-(Benzothiazol-2-yl)-2-(4H-[1,2,4]triazol-3-ylsulfanyl) acetamide deriva- tives (3a-j) were prepared by the reaction of N-(benzothiazol-2-yl)-2-chloroacetamides (1a-e) with appropriate 4H-[1,2,4]triazol-2-thione (2a-b). The chemical structures of the compounds were eluci- dated by elemental analyses, IR, ¹H-NMR, ¹³C-NMR and FAB+-MS spectral data. Their antimicrobial activities against Escherichia coli (NRRL B-3008), Staphylococcus aureus (ATCC 6538), Pseudomo- nas aeruginosa (ATCC 27853), Proteus vulgaris (NRRL B-123), Salmonella typhimurium (ATCC 13311), Methicillin-resistant Staphylococcus aureus (MRSA) (clinic isolate), Candida albicans (NRRL Y-12983) and Candida parapsilosis (NRRL Y-12696) were investigated. The results showed that all of the tested compounds were inactive against the test organisms |
topic |
Benzothiazole Triazole Antimicrobial activity |
url |
http://btd.anadolu.edu.tr/index.php/BTDC/article/viewFile/5/58 |
work_keys_str_mv |
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