The Pathogenesis of Rift Valley Fever

Rift Valley fever (RVF) is an emerging zoonotic disease distributed in sub-Saharan African countries and the Arabian Peninsula. The disease is caused by the Rift Valley fever virus (RVFV) of the family Bunyaviridae and the genus Phlebovirus. The virus is transmitted by mosquitoes, and virus replicat...

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Main Authors:	Tetsuro Ikegami, Shinji Makino
Format:	Article
Language:	English
Published:	MDPI AG 2011-05-01
Series:	Viruses
Subjects:	Rift Valley fever virus pathogenesis hemorrhagic fever encephalitis blindness
Online Access:	http://www.mdpi.com/1999-4915/3/5/493/

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spelling	doaj-ae3c53cf70884ce49ae5b7dc82b240562020-11-24T21:05:18ZengMDPI AGViruses1999-49152011-05-013549351910.3390/v3050493The Pathogenesis of Rift Valley FeverTetsuro IkegamiShinji MakinoRift Valley fever (RVF) is an emerging zoonotic disease distributed in sub-Saharan African countries and the Arabian Peninsula. The disease is caused by the Rift Valley fever virus (RVFV) of the family Bunyaviridae and the genus Phlebovirus. The virus is transmitted by mosquitoes, and virus replication in domestic ruminant results in high rates of mortality and abortion. RVFV infection in humans usually causes a self-limiting, acute and febrile illness; however, a small number of cases progress to neurological disorders, partial or complete blindness, hemorrhagic fever, or thrombosis. This review describes the pathology of RVF in human patients and several animal models, and summarizes the role of viral virulence factors and host factors that affect RVFV pathogenesis.http://www.mdpi.com/1999-4915/3/5/493/Rift Valley fever viruspathogenesishemorrhagic feverencephalitisblindness
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Tetsuro Ikegami Shinji Makino
spellingShingle	Tetsuro Ikegami Shinji Makino The Pathogenesis of Rift Valley Fever Viruses Rift Valley fever virus pathogenesis hemorrhagic fever encephalitis blindness
author_facet	Tetsuro Ikegami Shinji Makino
author_sort	Tetsuro Ikegami
title	The Pathogenesis of Rift Valley Fever
title_short	The Pathogenesis of Rift Valley Fever
title_full	The Pathogenesis of Rift Valley Fever
title_fullStr	The Pathogenesis of Rift Valley Fever
title_full_unstemmed	The Pathogenesis of Rift Valley Fever
title_sort	pathogenesis of rift valley fever
publisher	MDPI AG
series	Viruses
issn	1999-4915
publishDate	2011-05-01
description	Rift Valley fever (RVF) is an emerging zoonotic disease distributed in sub-Saharan African countries and the Arabian Peninsula. The disease is caused by the Rift Valley fever virus (RVFV) of the family Bunyaviridae and the genus Phlebovirus. The virus is transmitted by mosquitoes, and virus replication in domestic ruminant results in high rates of mortality and abortion. RVFV infection in humans usually causes a self-limiting, acute and febrile illness; however, a small number of cases progress to neurological disorders, partial or complete blindness, hemorrhagic fever, or thrombosis. This review describes the pathology of RVF in human patients and several animal models, and summarizes the role of viral virulence factors and host factors that affect RVFV pathogenesis.
topic	Rift Valley fever virus pathogenesis hemorrhagic fever encephalitis blindness
url	http://www.mdpi.com/1999-4915/3/5/493/
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The Pathogenesis of Rift Valley Fever

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