Small Molecular Prodrug Amphiphile Self-Assembled AIE Dots for Cancer Theranostics
A simple and facile one-step method was developed to construct a small molecular prodrug amphiphile self-assembled organic dots CPPG with aggregation-induced emission (AIE) characteristics. Diphenylalanine peptide (FF), which is the essential moiety of the self-assembling peptide-drug conjugate and...
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doaj-ae469c75b2434caa8726614ed431c9cc2020-11-25T03:57:26ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852020-10-01810.3389/fbioe.2020.00903571491Small Molecular Prodrug Amphiphile Self-Assembled AIE Dots for Cancer TheranosticsXing Yang0Xing Yang1Yuan Luo2Sanpeng Li3Xiuli Xu4Xiuli Xu5Yingxia Bao6Jiaming Yang7Defang Ouyang8Xingxing Fan9Ping Gong10Lintao Cai11Guangdong Key Laboratory of Nanomedicine, CAS-HK Joint Lab for Biomaterials, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, ChinaUniversity of Chinese Academy of Sciences, Beijing, ChinaGuangdong Key Laboratory of Nanomedicine, CAS-HK Joint Lab for Biomaterials, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, ChinaGuangdong Key Laboratory of Nanomedicine, CAS-HK Joint Lab for Biomaterials, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, ChinaGuangdong Key Laboratory of Nanomedicine, CAS-HK Joint Lab for Biomaterials, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, ChinaNano Science and Technology Institute, University of Science and Technology of China, Hefei, ChinaGuangzhou Baiyunshan Pharmaceutical Co., Ltd., Baiyunshan Pharmaceutical General Factory, Guangzhou, ChinaLivzon Mabpharm Inc., Zhuhai, ChinaState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences (ICMS), University of Macau, Macau, ChinaState Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Macau, ChinaGuangdong Key Laboratory of Nanomedicine, CAS-HK Joint Lab for Biomaterials, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, ChinaGuangdong Key Laboratory of Nanomedicine, CAS-HK Joint Lab for Biomaterials, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, ChinaA simple and facile one-step method was developed to construct a small molecular prodrug amphiphile self-assembled organic dots CPPG with aggregation-induced emission (AIE) characteristics. Diphenylalanine peptide (FF), which is the essential moiety of the self-assembling peptide-drug conjugate and as its core recognition motifs for molecular self-assembly. In addition, the D-glucose transported protein (GLUT), which is one of the important nutrient transporters and is overexpressed in cancer cells. The conjugation of glycosyl further endues the nanoparticle with good biocompatibility and tumor-targeting ability. Taking advantages of both the cancer cell-targeting capability of small molecular prodrug amphiphile CPPG and the AIE aggregates with strong emission, the prepared CPPG AIE dots can target cancer cells specifically and inhibit the proliferation of cancer cells with good biocompatibility and photostability. Based on the general approach, types of universal organic fluorescent nanoprobes could be facilely constructed for imaging applications and biological therapeutics, which possess the properties of specific recognition and high brightness.https://www.frontiersin.org/article/10.3389/fbioe.2020.00903/fullprodrugself-assemblyAIEcancertheranostics |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xing Yang Xing Yang Yuan Luo Sanpeng Li Xiuli Xu Xiuli Xu Yingxia Bao Jiaming Yang Defang Ouyang Xingxing Fan Ping Gong Lintao Cai |
spellingShingle |
Xing Yang Xing Yang Yuan Luo Sanpeng Li Xiuli Xu Xiuli Xu Yingxia Bao Jiaming Yang Defang Ouyang Xingxing Fan Ping Gong Lintao Cai Small Molecular Prodrug Amphiphile Self-Assembled AIE Dots for Cancer Theranostics Frontiers in Bioengineering and Biotechnology prodrug self-assembly AIE cancer theranostics |
author_facet |
Xing Yang Xing Yang Yuan Luo Sanpeng Li Xiuli Xu Xiuli Xu Yingxia Bao Jiaming Yang Defang Ouyang Xingxing Fan Ping Gong Lintao Cai |
author_sort |
Xing Yang |
title |
Small Molecular Prodrug Amphiphile Self-Assembled AIE Dots for Cancer Theranostics |
title_short |
Small Molecular Prodrug Amphiphile Self-Assembled AIE Dots for Cancer Theranostics |
title_full |
Small Molecular Prodrug Amphiphile Self-Assembled AIE Dots for Cancer Theranostics |
title_fullStr |
Small Molecular Prodrug Amphiphile Self-Assembled AIE Dots for Cancer Theranostics |
title_full_unstemmed |
Small Molecular Prodrug Amphiphile Self-Assembled AIE Dots for Cancer Theranostics |
title_sort |
small molecular prodrug amphiphile self-assembled aie dots for cancer theranostics |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Bioengineering and Biotechnology |
issn |
2296-4185 |
publishDate |
2020-10-01 |
description |
A simple and facile one-step method was developed to construct a small molecular prodrug amphiphile self-assembled organic dots CPPG with aggregation-induced emission (AIE) characteristics. Diphenylalanine peptide (FF), which is the essential moiety of the self-assembling peptide-drug conjugate and as its core recognition motifs for molecular self-assembly. In addition, the D-glucose transported protein (GLUT), which is one of the important nutrient transporters and is overexpressed in cancer cells. The conjugation of glycosyl further endues the nanoparticle with good biocompatibility and tumor-targeting ability. Taking advantages of both the cancer cell-targeting capability of small molecular prodrug amphiphile CPPG and the AIE aggregates with strong emission, the prepared CPPG AIE dots can target cancer cells specifically and inhibit the proliferation of cancer cells with good biocompatibility and photostability. Based on the general approach, types of universal organic fluorescent nanoprobes could be facilely constructed for imaging applications and biological therapeutics, which possess the properties of specific recognition and high brightness. |
topic |
prodrug self-assembly AIE cancer theranostics |
url |
https://www.frontiersin.org/article/10.3389/fbioe.2020.00903/full |
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