Conditional deletion of Nedd4-2 in lung epithelial cells causes progressive pulmonary fibrosis in adult mice
Idiopathic pulmonary fibrosis (IPF) is a devastating disease with poor prognosis. Here, the authors show that deficiency of the E3 ubiqutin-protein ligase Nedd4-2 in airway epithelial cells causes IPF-like disease in adult mice. This model may aid studies of the pathogenesis and therapy of IPF.
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Nature Publishing Group
2020-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-15743-6 |
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doaj-ae55c88d44b14c0496555b2c7a52b8da2021-05-11T08:18:15ZengNature Publishing GroupNature Communications2041-17232020-04-0111111810.1038/s41467-020-15743-6Conditional deletion of Nedd4-2 in lung epithelial cells causes progressive pulmonary fibrosis in adult miceJulia Duerr0Dominik H. W. Leitz1Magdalena Szczygiel2Dmytro Dvornikov3Simon G. Fraumann4Clemens Kreutz5Piotr K. Zadora6Ayça Seyhan Agircan7Philip Konietzke8Theresa A. Engelmann9Jan Hegermann10Surafel Mulugeta11Hiroshi Kawabe12Lars Knudsen13Matthias Ochs14Daniela Rotin15Thomas Muley16Michael Kreuter17Felix J. F. Herth18Mark O. Wielpütz19Michael F. Beers20Ursula Klingmüller21Marcus A. Mall22Department of Translational Pulmonology, University of Heidelberg, Im Neuenheimer Feld 156Department of Translational Pulmonology, University of Heidelberg, Im Neuenheimer Feld 156Translational Lung Research Center (TLRC), German Center for Lung Research (DZL), Im Neuenheimer Feld 156Translational Lung Research Center (TLRC), German Center for Lung Research (DZL), Im Neuenheimer Feld 156Department of Translational Pulmonology, University of Heidelberg, Im Neuenheimer Feld 156Institute of Medical Biometry and Statistics, University of Freiburg, Stefan-Meier-Straße 26Translational Lung Research Center (TLRC), German Center for Lung Research (DZL), Im Neuenheimer Feld 156Department of Translational Pulmonology, University of Heidelberg, Im Neuenheimer Feld 156Translational Lung Research Center (TLRC), German Center for Lung Research (DZL), Im Neuenheimer Feld 156Institute of Functional and Applied Anatomy, Hannover Medical SchoolInstitute of Functional and Applied Anatomy, Hannover Medical SchoolPulmonary, Allergy, and Critical Care Division, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center BoulevardDepartment of Molecular Neurobiology, Max Planck Institute of Experimental MedicineInstitute of Functional and Applied Anatomy, Hannover Medical SchoolInstitute of Functional and Applied Anatomy, Hannover Medical SchoolHospital for Sick Children and University of Toronto, 555 University AvenueTranslational Lung Research Center (TLRC), German Center for Lung Research (DZL), Im Neuenheimer Feld 156Translational Lung Research Center (TLRC), German Center for Lung Research (DZL), Im Neuenheimer Feld 156Translational Lung Research Center (TLRC), German Center for Lung Research (DZL), Im Neuenheimer Feld 156Translational Lung Research Center (TLRC), German Center for Lung Research (DZL), Im Neuenheimer Feld 156Pulmonary, Allergy, and Critical Care Division, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center BoulevardTranslational Lung Research Center (TLRC), German Center for Lung Research (DZL), Im Neuenheimer Feld 156Department of Translational Pulmonology, University of Heidelberg, Im Neuenheimer Feld 156Idiopathic pulmonary fibrosis (IPF) is a devastating disease with poor prognosis. Here, the authors show that deficiency of the E3 ubiqutin-protein ligase Nedd4-2 in airway epithelial cells causes IPF-like disease in adult mice. This model may aid studies of the pathogenesis and therapy of IPF.https://doi.org/10.1038/s41467-020-15743-6 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Julia Duerr Dominik H. W. Leitz Magdalena Szczygiel Dmytro Dvornikov Simon G. Fraumann Clemens Kreutz Piotr K. Zadora Ayça Seyhan Agircan Philip Konietzke Theresa A. Engelmann Jan Hegermann Surafel Mulugeta Hiroshi Kawabe Lars Knudsen Matthias Ochs Daniela Rotin Thomas Muley Michael Kreuter Felix J. F. Herth Mark O. Wielpütz Michael F. Beers Ursula Klingmüller Marcus A. Mall |
| spellingShingle |
Julia Duerr Dominik H. W. Leitz Magdalena Szczygiel Dmytro Dvornikov Simon G. Fraumann Clemens Kreutz Piotr K. Zadora Ayça Seyhan Agircan Philip Konietzke Theresa A. Engelmann Jan Hegermann Surafel Mulugeta Hiroshi Kawabe Lars Knudsen Matthias Ochs Daniela Rotin Thomas Muley Michael Kreuter Felix J. F. Herth Mark O. Wielpütz Michael F. Beers Ursula Klingmüller Marcus A. Mall Conditional deletion of Nedd4-2 in lung epithelial cells causes progressive pulmonary fibrosis in adult mice Nature Communications |
| author_facet |
Julia Duerr Dominik H. W. Leitz Magdalena Szczygiel Dmytro Dvornikov Simon G. Fraumann Clemens Kreutz Piotr K. Zadora Ayça Seyhan Agircan Philip Konietzke Theresa A. Engelmann Jan Hegermann Surafel Mulugeta Hiroshi Kawabe Lars Knudsen Matthias Ochs Daniela Rotin Thomas Muley Michael Kreuter Felix J. F. Herth Mark O. Wielpütz Michael F. Beers Ursula Klingmüller Marcus A. Mall |
| author_sort |
Julia Duerr |
| title |
Conditional deletion of Nedd4-2 in lung epithelial cells causes progressive pulmonary fibrosis in adult mice |
| title_short |
Conditional deletion of Nedd4-2 in lung epithelial cells causes progressive pulmonary fibrosis in adult mice |
| title_full |
Conditional deletion of Nedd4-2 in lung epithelial cells causes progressive pulmonary fibrosis in adult mice |
| title_fullStr |
Conditional deletion of Nedd4-2 in lung epithelial cells causes progressive pulmonary fibrosis in adult mice |
| title_full_unstemmed |
Conditional deletion of Nedd4-2 in lung epithelial cells causes progressive pulmonary fibrosis in adult mice |
| title_sort |
conditional deletion of nedd4-2 in lung epithelial cells causes progressive pulmonary fibrosis in adult mice |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2020-04-01 |
| description |
Idiopathic pulmonary fibrosis (IPF) is a devastating disease with poor prognosis. Here, the authors show that deficiency of the E3 ubiqutin-protein ligase Nedd4-2 in airway epithelial cells causes IPF-like disease in adult mice. This model may aid studies of the pathogenesis and therapy of IPF. |
| url |
https://doi.org/10.1038/s41467-020-15743-6 |
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