UCNP-based Photoluminescent Nanomedicines for Targeted Imaging and Theranostics of Cancer
Theranostic approach is currently among the fastest growing trends in cancer treatment. It implies the creation of multifunctional agents for simultaneous precise diagnosis and targeted impact on tumor cells. A new type of theranostic complexes was created based on NaYF<sub>4</sub>: Yb,T...
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MDPI AG
2020-09-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/25/18/4302 |
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doaj-ae5c289dd9c14a6da88a41f94703401c2020-11-25T03:43:30ZengMDPI AGMolecules1420-30492020-09-01254302430210.3390/molecules25184302UCNP-based Photoluminescent Nanomedicines for Targeted Imaging and Theranostics of CancerEvgenii L. Guryev0Anita S. Smyshlyaeva1Natalia Y. Shilyagina2Evgeniya A. Sokolova3Samah Shanwar4Alexey B. Kostyuk5Alexander V. Lyubeshkin6Alexey A. Schulga7Elena V. Konovalova8Quan Lin9Indrajit Roy10Irina V. Balalaeva11Sergey M. Deyev12Andrei V. Zvyagin13Institute of Biology and Biomedicine, Lobachevsky State University of Nizhny Novgorod, 603950 Nizhny Novgorod, RussiaInstitute of Biology and Biomedicine, Lobachevsky State University of Nizhny Novgorod, 603950 Nizhny Novgorod, RussiaInstitute of Biology and Biomedicine, Lobachevsky State University of Nizhny Novgorod, 603950 Nizhny Novgorod, RussiaInstitute of Biology and Biomedicine, Lobachevsky State University of Nizhny Novgorod, 603950 Nizhny Novgorod, RussiaInstitute of Biology and Biomedicine, Lobachevsky State University of Nizhny Novgorod, 603950 Nizhny Novgorod, RussiaInstitute of Biology and Biomedicine, Lobachevsky State University of Nizhny Novgorod, 603950 Nizhny Novgorod, RussiaFederal Scientific Research Center “Crystallography and Photonics”, Russian Academy of Sciences, 119333 Moscow, RussiaShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, RussiaShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, RussiaCollege of Chemistry, Jilin University, Changchun 130012, ChinaDepartment of Chemistry, University of Delhi, Delhi 110007, IndiaInstitute of Biology and Biomedicine, Lobachevsky State University of Nizhny Novgorod, 603950 Nizhny Novgorod, RussiaShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, RussiaInstitute of Biology and Biomedicine, Lobachevsky State University of Nizhny Novgorod, 603950 Nizhny Novgorod, RussiaTheranostic approach is currently among the fastest growing trends in cancer treatment. It implies the creation of multifunctional agents for simultaneous precise diagnosis and targeted impact on tumor cells. A new type of theranostic complexes was created based on NaYF<sub>4</sub>: Yb,Tm upconversion nanoparticles coated with polyethylene glycol and functionalized with the HER2-specific recombinant targeted toxin DARPin-LoPE. The obtained agents bind to HER2-overexpressing human breast adenocarcinoma cells and demonstrate selective cytotoxicity against this type of cancer cells. Using fluorescent human breast adenocarcinoma xenograft models, the possibility of intravital visualization of the UCNP-based complexes biodistribution and accumulation in tumor was demonstrated.https://www.mdpi.com/1420-3049/25/18/4302immunoconjugatestumorimagingtherapydrugantigen |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Evgenii L. Guryev Anita S. Smyshlyaeva Natalia Y. Shilyagina Evgeniya A. Sokolova Samah Shanwar Alexey B. Kostyuk Alexander V. Lyubeshkin Alexey A. Schulga Elena V. Konovalova Quan Lin Indrajit Roy Irina V. Balalaeva Sergey M. Deyev Andrei V. Zvyagin |
| spellingShingle |
Evgenii L. Guryev Anita S. Smyshlyaeva Natalia Y. Shilyagina Evgeniya A. Sokolova Samah Shanwar Alexey B. Kostyuk Alexander V. Lyubeshkin Alexey A. Schulga Elena V. Konovalova Quan Lin Indrajit Roy Irina V. Balalaeva Sergey M. Deyev Andrei V. Zvyagin UCNP-based Photoluminescent Nanomedicines for Targeted Imaging and Theranostics of Cancer Molecules immunoconjugates tumor imaging therapy drug antigen |
| author_facet |
Evgenii L. Guryev Anita S. Smyshlyaeva Natalia Y. Shilyagina Evgeniya A. Sokolova Samah Shanwar Alexey B. Kostyuk Alexander V. Lyubeshkin Alexey A. Schulga Elena V. Konovalova Quan Lin Indrajit Roy Irina V. Balalaeva Sergey M. Deyev Andrei V. Zvyagin |
| author_sort |
Evgenii L. Guryev |
| title |
UCNP-based Photoluminescent Nanomedicines for Targeted Imaging and Theranostics of Cancer |
| title_short |
UCNP-based Photoluminescent Nanomedicines for Targeted Imaging and Theranostics of Cancer |
| title_full |
UCNP-based Photoluminescent Nanomedicines for Targeted Imaging and Theranostics of Cancer |
| title_fullStr |
UCNP-based Photoluminescent Nanomedicines for Targeted Imaging and Theranostics of Cancer |
| title_full_unstemmed |
UCNP-based Photoluminescent Nanomedicines for Targeted Imaging and Theranostics of Cancer |
| title_sort |
ucnp-based photoluminescent nanomedicines for targeted imaging and theranostics of cancer |
| publisher |
MDPI AG |
| series |
Molecules |
| issn |
1420-3049 |
| publishDate |
2020-09-01 |
| description |
Theranostic approach is currently among the fastest growing trends in cancer treatment. It implies the creation of multifunctional agents for simultaneous precise diagnosis and targeted impact on tumor cells. A new type of theranostic complexes was created based on NaYF<sub>4</sub>: Yb,Tm upconversion nanoparticles coated with polyethylene glycol and functionalized with the HER2-specific recombinant targeted toxin DARPin-LoPE. The obtained agents bind to HER2-overexpressing human breast adenocarcinoma cells and demonstrate selective cytotoxicity against this type of cancer cells. Using fluorescent human breast adenocarcinoma xenograft models, the possibility of intravital visualization of the UCNP-based complexes biodistribution and accumulation in tumor was demonstrated. |
| topic |
immunoconjugates tumor imaging therapy drug antigen |
| url |
https://www.mdpi.com/1420-3049/25/18/4302 |
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